LEPROTL1 - leptin receptor overlapping transcript like 1 Gene

Also Known as Vps55; my047; HSPC112

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23484

About LEPROTL1

Cytogenetic location: 8p12 Genomic coordinates (GRCh38): 8:30,095,408-30,138,348 (from NCBI)

This gene has 9 transcripts (splice variants), 212 orthologues, 1 paralogue and is associated with 55 phenotypes. Ubiquitous expression in placenta (RPKM 29.1), lymph node (RPKM 17.8) and 24 other tissues.

Summary

Enables identical protein binding activity. Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway and negative regulation of growth hormone receptor signaling pathway. Predicted to be integral component of membrane. Predicted to be active in endosome. [provided by Alliance of Genome Resources, Apr 2022]

LEPROTL1 Products (2)

mRNA Protein Name
NM_001128208.2 NP_001121680.1 leptin receptor overlapping transcript-like 1 isoform 2
NM_015344.3 NP_056159.2 leptin receptor overlapping transcript-like 1 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LEPROTL1 Protein Structure

Vps55

Vps55: Vacuolar protein sorting 55 (7 - 125)

  • 0
  • 100
  • 131 a.a.
Protein Preferred Names Protein Names

leptin receptor overlapping transcript-like 1

  • endospanin-2

LEPROTL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LEPROTL1 O95214 RTP2 Homo sapiens Q5QGT7
Validated Y2H
32296183
Intra
LEPROTL1 O95214 NRM Homo sapiens Q8IXM6
Validated Y2H
32296183
Intra
LEPROTL1 O95214 SLC25A46 Homo sapiens Q96AG3
Validated Y2H
32296183
Intra
LEPROTL1 O95214 TMEM248 Homo sapiens Q9NWD8
Validated Y2H
32296183
Intra
LEPROTL1 O95214 TMEM248 Homo sapiens Q9NWD8
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 TMEM248 Homo sapiens Q9NWD8
Y2H Array
32296183
Intra
LEPROTL1 O95214 CISD2 Homo sapiens Q8N5K1
Y2H Array
32296183
Intra
LEPROTL1 O95214 CISD2 Homo sapiens Q8N5K1
Validated Y2H
32296183
Intra
LEPROTL1 O95214 CISD2 Homo sapiens Q8N5K1
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 ORMDL1 Homo sapiens Q9P0S3
Validated Y2H
32296183
Intra
LEPROTL1 O95214 VAPA Homo sapiens Q9P0L0
Validated Y2H
32296183
Intra
LEPROTL1 O95214 TMEM237 Homo sapiens Q96Q45-2
Validated Y2H
32296183
Intra
LEPROTL1 O95214 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
Intra
LEPROTL1 O95214 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 ARL13B Homo sapiens Q3SXY8
Validated Y2H
32296183
Intra
LEPROTL1 O95214 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
LEPROTL1 O95214 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra
LEPROTL1 O95214 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
LEPROTL1 O95214 CLEC2D Homo sapiens Q9UHP7-3
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 CLEC2D Homo sapiens Q9UHP7-3
Validated Y2H
32296183
Intra
LEPROTL1 O95214 CLEC2D Homo sapiens Q9UHP7-3
Y2H Array
32296183
Intra
LEPROTL1 O95214 KCNJ6 Homo sapiens P48051
Y2H Array
32296183
Intra
LEPROTL1 O95214 KCNJ6 Homo sapiens P48051
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 KCNJ6 Homo sapiens P48051
Validated Y2H
32296183
Intra
LEPROTL1 O95214 LPAR3 Homo sapiens Q9UBY5
Validated Y2H
32296183
Intra
LEPROTL1 O95214 TMEM42 Homo sapiens Q69YG0
Validated Y2H
32296183
Intra
LEPROTL1 O95214 PLP1 Homo sapiens P60201-2
Validated Y2H
32296183
Intra
LEPROTL1 O95214 TMEM50B Homo sapiens P56557
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 TMEM50B Homo sapiens P56557
Validated Y2H
32296183
Intra
LEPROTL1 O95214 TMEM50B Homo sapiens P56557
Y2H Array
32296183
Intra
LEPROTL1 O95214 TGFA Homo sapiens P01135-2
Y2H Array
32296183
Intra
LEPROTL1 O95214 TGFA Homo sapiens P01135-2
Validated Y2H
32296183
Intra
LEPROTL1 O95214 TGFA Homo sapiens P01135-2
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 FMO1 Homo sapiens Q01740
Validated Y2H
32296183
Intra
LEPROTL1 O95214 FMO1 Homo sapiens Q01740
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 FMO1 Homo sapiens Q01740
Y2H Array
32296183
Intra
LEPROTL1 O95214 ZDHHC15 Homo sapiens Q96MV8
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 ZDHHC15 Homo sapiens Q96MV8
Validated Y2H
32296183
Intra
LEPROTL1 O95214 ZDHHC15 Homo sapiens Q96MV8
Y2H Array
32296183
Intra
LEPROTL1 O95214 PAQR8 Homo sapiens Q8TEZ7
Validated Y2H
32296183
Intra
LEPROTL1 O95214 TMEM50A Homo sapiens O95807
Validated Y2H
32296183
Intra
LEPROTL1 O95214 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra
LEPROTL1 O95214 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
LEPROTL1 O95214 SLC30A4 Homo sapiens O14863
Y2H Array
32296183
Intra
LEPROTL1 O95214 SLC30A4 Homo sapiens O14863
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 REEP6 Homo sapiens Q96HR9-2
Validated Y2H
32296183
Intra
LEPROTL1 O95214 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
Intra
LEPROTL1 O95214 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra
LEPROTL1 O95214 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 SSMEM1 Homo sapiens Q8WWF3
Validated Y2H
32296183
Intra
LEPROTL1 O95214 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra
LEPROTL1 O95214 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 SLC35C2 Homo sapiens Q9NQQ7-3
Validated Y2H
32296183
Intra
LEPROTL1 O95214 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra
LEPROTL1 O95214 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 GJA8 Homo sapiens P48165
Validated Y2H
32296183
Intra
LEPROTL1 O95214 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra
LEPROTL1 O95214 CYP4F2 Homo sapiens P78329
Validated Y2H
32296183
Intra
LEPROTL1 O95214 AGPAT4 Homo sapiens Q9NRZ5
Validated Y2H
32296183
Intra
LEPROTL1 O95214 MSR1 Homo sapiens P21757
Y2H Array
31515488
Intra
LEPROTL1 O95214 MSR1 Homo sapiens P21757
Validated Y2H
32296183
Intra
LEPROTL1 O95214 MSR1 Homo sapiens P21757
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 MSR1 Homo sapiens P21757
Y2H Array
32296183
Intra
LEPROTL1 O95214 GPR42 Homo sapiens O15529
Y2H Array
32296183
Intra
LEPROTL1 O95214 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 ELOVL4 Homo sapiens Q9GZR5
Validated Y2H
32296183
Intra
LEPROTL1 O95214 ELOVL4 Homo sapiens Q9GZR5
Y2H Array
32296183
Intra
LEPROTL1 O95214 ELOVL4 Homo sapiens Q9GZR5
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 EHHADH Homo sapiens Q08426
Validated Y2H
32296183
Intra
LEPROTL1 O95214 STX12 Homo sapiens Q86Y82
Validated Y2H
32296183
Intra
LEPROTL1 O95214 STING1 Homo sapiens Q86WV6
Validated Y2H
32296183
Intra
LEPROTL1 O95214 STING1 Homo sapiens Q86WV6
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 STING1 Homo sapiens Q86WV6
Y2H Array
32296183
Intra
LEPROTL1 O95214 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra
LEPROTL1 O95214 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 TMEM60 Homo sapiens Q9H2L4
Validated Y2H
32296183
Intra
LEPROTL1 O95214 NAT8 Homo sapiens Q9UHE5
Validated Y2H
32296183
Intra
LEPROTL1 O95214 RBFA Homo sapiens Q8N0V3
Validated Y2H
32296183
Intra
LEPROTL1 O95214 RNF5 Homo sapiens Q99942
Validated Y2H
32296183
Intra
LEPROTL1 O95214 RNF5 Homo sapiens Q99942
Y2H Array
32296183
Intra
LEPROTL1 O95214 RNF5 Homo sapiens Q99942
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 MFSD14B Homo sapiens Q5SR56
Y2H Array
32296183
Intra
LEPROTL1 O95214 MFSD14B Homo sapiens Q5SR56
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 MFSD14B Homo sapiens Q5SR56
Validated Y2H
32296183
Intra
LEPROTL1 O95214 CD300C Homo sapiens Q08708
Validated Y2H
32296183
Intra
LEPROTL1 O95214 LRRC4C Homo sapiens Q9HCJ2
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 LRRC4C Homo sapiens Q9HCJ2
Validated Y2H
32296183
Intra
LEPROTL1 O95214 LRRC4C Homo sapiens Q9HCJ2
Y2H Array
32296183
Intra
LEPROTL1 O95214 SLC7A1 Homo sapiens P30825
Validated Y2H
32296183
Intra
LEPROTL1 O95214 SLC7A1 Homo sapiens P30825
Y2H Array
32296183
Intra
LEPROTL1 O95214 SLC7A1 Homo sapiens P30825
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 EMP1 Homo sapiens P54849
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 EMP1 Homo sapiens P54849
Validated Y2H
32296183
Intra
LEPROTL1 O95214 EMP1 Homo sapiens P54849
Y2H Array
32296183
Intra
LEPROTL1 O95214 JPH1 Homo sapiens Q9HDC5
Validated Y2H
32296183
Intra
LEPROTL1 O95214 JPH1 Homo sapiens Q9HDC5
Y2H Array
32296183
Intra
LEPROTL1 O95214 JPH1 Homo sapiens Q9HDC5
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 EDA Homo sapiens Q92838
Y2H Array
31515488
Intra
LEPROTL1 O95214 EDA Homo sapiens Q92838
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 EDA Homo sapiens Q92838
Validated Y2H
32296183
Intra
LEPROTL1 O95214 EDA Homo sapiens Q92838
Y2H Array
32296183
Intra
LEPROTL1 O95214 LMBR1 Homo sapiens Q8WVP7
Validated Y2H
32296183
Intra
LEPROTL1 O95214 LMBR1 Homo sapiens Q8WVP7
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 LMBR1 Homo sapiens Q8WVP7
Y2H Array
32296183
Intra
LEPROTL1 O95214 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
LEPROTL1 O95214 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
LEPROTL1 O95214 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
LEPROTL1 O95214 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
LEPROTL1 O95214 PDZK1IP1 Homo sapiens Q13113
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 PDZK1IP1 Homo sapiens Q13113
Validated Y2H
32296183
Intra
LEPROTL1 O95214 PDZK1IP1 Homo sapiens Q13113
Y2H Array
32296183
Intra
LEPROTL1 O95214 ORMDL3 Homo sapiens Q8N138
Validated Y2H
32296183
Intra
LEPROTL1 O95214 TMEM11 Homo sapiens P17152
Validated Y2H
32296183
Intra
LEPROTL1 O95214 SYNDIG1 Homo sapiens Q9H7V2
Validated Y2H
32296183
Intra
LEPROTL1 O95214 SYNDIG1 Homo sapiens Q9H7V2
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 SYNDIG1 Homo sapiens Q9H7V2
Y2H Array
32296183
Intra
LEPROTL1 O95214 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
LEPROTL1 O95214 CLDN7 Homo sapiens O95471
Validated Y2H
32296183
Intra
LEPROTL1 O95214 CLDN7 Homo sapiens O95471
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 CLDN7 Homo sapiens O95471
Y2H Array
32296183
Intra
LEPROTL1 O95214 TMEM19 Homo sapiens Q96HH6
Validated Y2H
32296183
Intra
LEPROTL1 O95214 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
Intra
LEPROTL1 O95214 MALL Homo sapiens Q13021
Validated Y2H
32296183
Intra
LEPROTL1 O95214 GJA5 Homo sapiens P36382
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 GJA5 Homo sapiens P36382
Validated Y2H
32296183
Intra
LEPROTL1 O95214 GJA5 Homo sapiens P36382
Y2H Array
32296183
Intra
LEPROTL1 O95214 KLRG1 Homo sapiens Q96E93
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 KLRG1 Homo sapiens Q96E93
Validated Y2H
32296183
Intra
LEPROTL1 O95214 KLRG1 Homo sapiens Q96E93
Y2H Array
32296183
Intra
LEPROTL1 O95214 YIPF2 Homo sapiens Q9BWQ6
Validated Y2H
32296183
Intra
LEPROTL1 O95214 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
Intra
LEPROTL1 O95214 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 REEP4 Homo sapiens Q9H6H4
Validated Y2H
32296183
Intra
LEPROTL1 O95214 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
LEPROTL1 O95214 CD79A Homo sapiens P11912
Validated Y2H
32296183
Intra
LEPROTL1 O95214 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
LEPROTL1 O95214 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra
LEPROTL1 O95214 SMCO4 Homo sapiens Q9NRQ5
Validated Y2H
32296183
Intra
LEPROTL1 O95214 PEX16 Homo sapiens Q9Y5Y5
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Rectal Benign Neoplasm

  • Neoplasm Of Rectum

  • Rectal Tumor

  • Rectum Neoplasm

  • Neoplasm Of The Rectum

  • Rectal Neoplasms

  • Primary Rectal Cancer

  • Rectal Ampulla Cancer

  • Cancer Of The Rectum

  • Carcinoma Of Rectum

  • Primary Malignant Neoplasm Of Rectum

  • Rectal Cancer

  • Rectal Carcinoma
Esophagus Adenocarcinoma

  • Esophageal Adenocarcinoma

  • Oesophageal Adenocarcinoma

  • Adenocarcinoma Of Esophagus

  • Adenocarcinoma Of The Esophagus
Rectum Adenocarcinoma

  • Rectal Adenocarcinoma

  • Adenocarcinoma Of Rectum
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07596 LEPROTL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus LEPROTL1 VGNC VGNC:30845
Rattus norvegicus LEPROTL1 RGD RGD:1307168
Macaca mulatta LEPROTL1 VGNC VGNC:74252
Felis catus LEPROTL1 VGNC VGNC:78521
Mus musculus LEPROTL1 MGD MGI:1915442
Canis familiaris LEPROTL1 VGNC VGNC:42640
Others LEPROTL1 NCBI