TMEM11 - transmembrane protein 11 Gene

Also Known as PM1; PMI; C17orf35

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8834

About TMEM11

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:21,197,954-21,214,161 (from NCBI)

This gene has 6 transcripts (splice variants) and 222 orthologues. Ubiquitous expression in fat (RPKM 9.9), bone marrow (RPKM 9.5) and 25 other tissues.

Summary

Involved in mitochondrion organization. Located in mitochondrion. Is integral component of mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM11 Products (1)

mRNA	Protein	Name
NM_003876.3	NP_003867.1	transmembrane protein 11, mitochondrial

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mitochondrion organization	IMP IMP: Inferred from mutant phenotype	21274005	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	21274005	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM11 Protein Structure

Mito_morph_reg

0
100
192 a.a.

Protein Preferred Names	Protein Names
transmembrane protein 11, mitochondrial	putative receptor protein

TMEM11 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TMEM11	P17152	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	RETREG3	Homo sapiens	Q86VR2	Validated Y2H	32296183
Intra	TMEM11	P17152	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	TMEM11	P17152	SLC30A8	Homo sapiens	Q8IWU4	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	SLC30A8	Homo sapiens	Q8IWU4	Validated Y2H	32296183
Intra	TMEM11	P17152	SLC30A8	Homo sapiens	Q8IWU4	Y2H Array	32296183
Intra	TMEM11	P17152	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	TMEM237	Homo sapiens	Q96Q45-2	Validated Y2H	32296183
Intra	TMEM11	P17152	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	TMEM11	P17152	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	ARL13B	Homo sapiens	Q3SXY8	Validated Y2H	32296183
Intra	TMEM11	P17152	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	TMEM11	P17152	NDUFS3	Homo sapiens	O75489	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	NDUFS3	Homo sapiens	O75489	Y2H Array	32296183
Intra	TMEM11	P17152	TMPRSS2	Homo sapiens	O15393-2	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	TMPRSS2	Homo sapiens	O15393-2	Y2H Array	32296183
Intra	TMEM11	P17152	RIC3	Homo sapiens	Q7Z5B4-5	Y2H Array	32296183
Intra	TMEM11	P17152	RIC3	Homo sapiens	Q7Z5B4-5	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	RIC3	Homo sapiens	Q7Z5B4-5	Validated Y2H	32296183
Intra	TMEM11	P17152	GJB4	Homo sapiens	Q9NTQ9	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	GJB4	Homo sapiens	Q9NTQ9	Validated Y2H	32296183
Intra	TMEM11	P17152	GJB4	Homo sapiens	Q9NTQ9	Y2H Array	32296183
Intra	TMEM11	P17152	TMEM88	Homo sapiens	Q6PEY1	Validated Y2H	32296183
Intra	TMEM11	P17152	TMEM88	Homo sapiens	Q6PEY1	Y2H Array	32296183
Intra	TMEM11	P17152	TMEM88	Homo sapiens	Q6PEY1	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	TMEM11	P17152	SLC10A6	Homo sapiens	Q3KNW5	Validated Y2H	32296183
Intra	TMEM11	P17152	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	TMEM11	P17152	SUSD3	Homo sapiens	Q96L08	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	SUSD3	Homo sapiens	Q96L08	Y2H Array	32296183
Intra	TMEM11	P17152	SUSD3	Homo sapiens	Q96L08	Validated Y2H	32296183
Intra	TMEM11	P17152	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	TMEM11	P17152	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	TMEM11	P17152	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183
Intra	TMEM11	P17152	ELOVL4	Homo sapiens	Q9GZR5	Validated Y2H	32296183
Intra	TMEM11	P17152	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	FAM174A	Homo sapiens	Q8TBP5	Validated Y2H	32296183
Intra	TMEM11	P17152	FAM174A	Homo sapiens	Q8TBP5	Y2H Array	32296183
Intra	TMEM11	P17152	FAM174A	Homo sapiens	Q8TBP5	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	FAM210B	Homo sapiens	Q96KR6	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	FAM210B	Homo sapiens	Q96KR6	Validated Y2H	32296183
Intra	TMEM11	P17152	FAM210B	Homo sapiens	Q96KR6	Y2H Array	32296183
Intra	TMEM11	P17152	TEX29	Homo sapiens	Q8N6K0	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	TEX29	Homo sapiens	Q8N6K0	Validated Y2H	32296183
Intra	TMEM11	P17152	TEX29	Homo sapiens	Q8N6K0	Y2H Array	32296183
Intra	TMEM11	P17152	CYB5D2	Homo sapiens	Q8WUJ1	Validated Y2H	32296183
Intra	TMEM11	P17152	CYB5D2	Homo sapiens	Q8WUJ1	Y2H Array	32296183
Intra	TMEM11	P17152	CYB5D2	Homo sapiens	Q8WUJ1	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	RNASEH1	Homo sapiens	O60930	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	RNASEH1	Homo sapiens	O60930	Y2H Array	32296183
Intra	TMEM11	P17152	TMEM106C	Homo sapiens	Q9BVX2	Validated Y2H	32296183
Intra	TMEM11	P17152	TMEM106C	Homo sapiens	Q9BVX2	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	TMEM106C	Homo sapiens	Q9BVX2	Y2H Array	32296183
Intra	TMEM11	P17152	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	TMEM11	P17152	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	EBP	Homo sapiens	Q15125	Validated Y2H	32296183
Intra	TMEM11	P17152	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	TMEM11	P17152	GORAB	Homo sapiens	Q5T7V8	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	GORAB	Homo sapiens	Q5T7V8	Y2H Array	32296183
Intra	TMEM11	P17152	GORAB	Homo sapiens	Q5T7V8	Validated Y2H	32296183
Intra	TMEM11	P17152	MTIF3	Homo sapiens	Q9H2K0	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	MTIF3	Homo sapiens	Q9H2K0	Validated Y2H	32296183
Intra	TMEM11	P17152	MTIF3	Homo sapiens	Q9H2K0	Y2H Array	32296183
Intra	TMEM11	P17152	TNFSF14	Homo sapiens	O43557	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	TNFSF14	Homo sapiens	O43557	Y2H Array	32296183
Intra	TMEM11	P17152	MRM1	Homo sapiens	Q6IN84	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	MRM1	Homo sapiens	Q6IN84	Validated Y2H	32296183
Intra	TMEM11	P17152	MRM1	Homo sapiens	Q6IN84	Y2H Array	32296183
Intra	TMEM11	P17152	SGCB	Homo sapiens	Q16585	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	SGCB	Homo sapiens	Q16585	Validated Y2H	32296183
Intra	TMEM11	P17152	SGCB	Homo sapiens	Q16585	Y2H Array	32296183
Intra	TMEM11	P17152	PEX12	Homo sapiens	O00623	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	PEX12	Homo sapiens	O00623	Y2H Array	32296183
Intra	TMEM11	P17152	TMEM205	Homo sapiens	Q6UW68	Y2H Array	32296183
Intra	TMEM11	P17152	TMEM205	Homo sapiens	Q6UW68	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	TMEM205	Homo sapiens	Q6UW68	Validated Y2H	32296183
Intra	TMEM11	P17152	CCDC70	Homo sapiens	Q6NSX1	Validated Y2H	32296183
Intra	TMEM11	P17152	CCDC70	Homo sapiens	Q6NSX1	Y2H Array	32296183
Intra	TMEM11	P17152	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	CREB3L1	Homo sapiens	Q96BA8	Y2H	21516116
Intra	TMEM11	P17152	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	TMEM11	P17152	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	TMEM11	P17152	BIK	Homo sapiens	Q13323	Validated Y2H	32296183
Intra	TMEM11	P17152	BIK	Homo sapiens	Q13323	Y2H Array	32296183
Intra	TMEM11	P17152	BIK	Homo sapiens	Q13323	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	PDZK1IP1	Homo sapiens	Q13113	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	PDZK1IP1	Homo sapiens	Q13113	Validated Y2H	32296183
Intra	TMEM11	P17152	PDZK1IP1	Homo sapiens	Q13113	Y2H Array	32296183
Intra	TMEM11	P17152	CLDN7	Homo sapiens	O95471	Y2H Array	32296183
Intra	TMEM11	P17152	CLDN7	Homo sapiens	O95471	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	FATE1	Homo sapiens	Q969F0	Y2H Array	32296183
Intra	TMEM11	P17152	FATE1	Homo sapiens	Q969F0	Validated Y2H	32296183
Intra	TMEM11	P17152	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	KASH5	Homo sapiens	Q8N6L0	Validated Y2H	32296183
Intra	TMEM11	P17152	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	KASH5	Homo sapiens	Q8N6L0	BFG-2H	27107012
Intra	TMEM11	P17152	KASH5	Homo sapiens	Q8N6L0	Y2H Array	32296183
Intra	TMEM11	P17152	BNIP3	Homo sapiens	Q12983	BFG-2H	27107012
Intra	TMEM11	P17152	BNIP3	Homo sapiens	Q12983	Pull Down	16189514
Intra	TMEM11	P17152	BNIP3	Homo sapiens	Q12983	Validated Y2H	25416956
Intra	TMEM11	P17152	BNIP3	Homo sapiens	Q12983	Validated Y2H	32296183
Intra	TMEM11	P17152	BNIP3	Homo sapiens	Q12983	Y2H Array	25416956
Intra	TMEM11	P17152	LEPROTL1	Homo sapiens	O95214	Y2H Array	32296183
Intra	TMEM11	P17152	LEPROTL1	Homo sapiens	O95214	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	YIPF6	Homo sapiens	Q96EC8	Y2H Array	32296183
Intra	TMEM11	P17152	YIPF6	Homo sapiens	Q96EC8	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	YIPF6	Homo sapiens	Q96EC8	Validated Y2H	32296183
Intra	TMEM11	P17152	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	TMEM11	P17152	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	BNIP3L	Homo sapiens	O60238	Validated Y2H	25416956
Intra	TMEM11	P17152	BNIP3L	Homo sapiens	O60238	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	BNIP3L	Homo sapiens	O60238	BFG-2H	27107012
Intra	TMEM11	P17152	BNIP3L	Homo sapiens	O60238	Y2H Array	32296183
Intra	TMEM11	P17152	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	TMEM11	P17152	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	TMEM11	P17152	CYB561	Homo sapiens	P49447	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	CYB561	Homo sapiens	P49447	Validated Y2H	32296183
Intra	TMEM11	P17152	CYB561	Homo sapiens	P49447	Y2H Array	32296183
Intra	TMEM11	P17152	OTX2	Homo sapiens	P32243-2	Y2H Array	32296183
Intra	TMEM11	P17152	OTX2	Homo sapiens	P32243-2	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	OTX2	Homo sapiens	P32243-2	Validated Y2H	32296183
Intra	TMEM11	P17152	MSMO1	Homo sapiens	Q15800	Y2H Prey Pooling	32296183
Intra	TMEM11	P17152	MSMO1	Homo sapiens	Q15800	Validated Y2H	32296183
Intra	TMEM11	P17152	MSMO1	Homo sapiens	Q15800	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cortical Dysplasia, Complex, With Other Brain Malformations 3	Complex Cortical Dysplasia With Other Brain Malformations 3 CDCBM3 Dysplasia ,Cortical, Complex, With Other Brain Malformations, Type 3
Penicilliosis
Deafness, Autosomal Dominant 69	DCUA DFNA69 Deafness, Congenital, Unilateral Or Asymmetric Deafness, Autosomal Dominant 69, Unilateral Or Asymmetric Autosomal Dominant Nonsyndromic Deafness 69 Autosomal Dominant Deafness 69 Unilateral Or Asymmetric Congenital Deafness
Combined Oxidative Phosphorylation Deficiency 21	COXPD21 Combined Oxidative Phosphorylation Defect Type 21 Combined Oxidative Phosphorylation Deficiency, Type 21
Autosomal Dominant Intellectual Developmental Disorder 31	Autosomal Dominant Non-Syndromic Intellectual Disability 31 Autosomal Dominant Mental Retardation 31 Mrd31
Epilepsy, X-Linked, With Variable Learning Disabilities And Behavior Disorders	X-Linked Epilepsy-Learning Disabilities-Behavior Disorders Syndrome EPILX X-Linked Epilepsy With Variable Learning Disabilities And Behavior Disorders Epilepsy, X-Linked, With Reflex Bathing Seizures Bathing Epilepsy, X-Linked
Parkinson Disease 17	PARK17 Parkinson'S Disease 17 Autosomal Dominant Parkinson Disease 17 Parkinson Disease, Type 17
Trichorhinophalangeal Syndrome, Type Iii	Trichorhinophalangeal Syndrome Type Iii TRPS3 Sugio-Kajii Syndrome Trichorhinophalangeal Syndrome Type 3 Trps 3 Tricho-Rhino-Phalangeal Syndrome 3
Sick Building Syndrome
Parotid Gland Adenoid Cystic Carcinoma	Adenoid Cystic Carcinoma Of Parotid Gland
Hyperchlorhidrosis, Isolated	Isolated Hyperchlorhidrosis HYCHL Carbonic Anhydrase Xii Deficiency
Pediculus Humanus Capitis Infestation	Pediculosis Capitis Pediculus Capitis Infestation Head Louse Infestation Pediculus Capitis Head-Louse Infestation Head Lice Infestation By Pediculus Capitis
Arthrogryposis, Renal Dysfunction, And Cholestasis 1	Arc Syndrome ARCS1 Arthrogryposis Renal Dysfunction Cholestasis Syndrome Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome Arcs Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome Arthrogryposis, Renal Dysfunction, And Cholestasis Arthrogryposis-Renal Dysfunction-Cholestasis Arthrogryposis - Renal Dysfunction - Cholestasis Arthrogryposis Multiplex Congenita, Renal Dysfunction, And Cholestasis Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 1 Arthrogryposis Renal Dysfunction And Cholestasis 1 Arthrogryposis With Renal Dysfunction And Cholestasis Syndrome Arthrogryposis, Renal Dysfunction, Cholestasis, Type 1 Kidney Failure Renal Insufficiency
Focal Segmental Glomerulosclerosis 1	FSGS1 Glomerulosclerosis, Focal Segmental, 1 Glomerulosclerosis, Segmental, Focal, Type 1 Segmental Glomerulosclerosis
Microphthalmia, Syndromic 13	X-Linked Colobomatous Microphthalmia-Microcephaly-Intellectual Disability-Short Stature Syndrome MCOPS13 Maine Microphthalmos Colobomatous Microphthalmia With Microcephaly, Short Stature, And Psychomotor Retardation Syndromic Microphthalmia 13 X-Linked Colobomatous Microphthalmia-Microcephaly-Short Stature-Psychomotor Retardation Syndrome Microphthalmia, Syndromic, 13 Microphthalmia, Syndromic, Type 13
Pediculus Humanus Corporis Infestation	Body Louse Infestation Pediculus Corporis Pediculus Humanus Infestation
Developmental And Epileptic Encephalopathy 87	DEE87 Epileptic Encephalopathy, Early Infantile, 87 Eiee87 Developmental And Epileptic Encephalopathy, 87 Early Infantile Epileptic Encephalopathy 87
Hard Palate Cancer	Malignant Neoplasm Of Hard Palate Malignant Tumor Of Hard Palate Malignant Tumour Of Hard Palate
Hypogonadotropic Hypogonadism 2 With Or Without Anosmia	Kallmann Syndrome 2 Kal2 HH2 Hypogonadism, Hypogonadotropic, Type 2 With/Without Anosmia
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14651	TMEM11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TMEM11	VGNC	VGNC:66260
Mus musculus	TMEM11	MGD	MGI:2144726
Canis familiaris	TMEM11	VGNC	VGNC:47451
Macaca mulatta	TMEM11	VGNC	VGNC:82256
Bos taurus	TMEM11	VGNC	VGNC:35950
Rattus norvegicus	TMEM11	RGD	RGD:1309817
Others	TMEM11	NCBI