SLC30A8 - solute carrier family 30 member 8 Gene
Also Known as ZNT8; ZnT-8
Species: Homo sapiens
About SLC30A8
This gene has 9 transcripts (splice variants), 201 orthologues, 8 paralogues and is associated with 1 phenotype. Biased expression in pancreas (RPKM 4.1), kidney (RPKM 1.7) and 5 other tissues.
Summary
The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with Insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
SLC30A8 Products (5)
| mRNA | Protein | Name |
|---|---|---|
| NM_001172811.2 | NP_001166282.1 | zinc transporter 8 isoform b |
| NM_001172813.2 | NP_001166284.1 | zinc transporter 8 isoform b |
| NM_001172814.2 | NP_001166285.1 | zinc transporter 8 isoform b |
| NM_001172815.3 | NP_001166286.1 | zinc transporter 8 isoform b |
| NM_173851.3 | NP_776250.2 | zinc transporter 8 isoform a |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
24955142 | GOA |
| enables zinc ion transmembrane transporter activity |
IDA
IDA: Inferred from direct assay
|
15331542 | GOA |
| enables zinc:proton antiporter activity |
IDA
IDA: Inferred from direct assay
|
32723473 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in insulin secretion |
IMP
IMP: Inferred from mutant phenotype
|
16984975 | GOA |
| involved in response to glucose |
IMP
IMP: Inferred from mutant phenotype
|
16984975 | GOA |
| involved in zinc ion import into organelle |
IMP
IMP: Inferred from mutant phenotype
|
16984975 | GOA |
| involved in zinc ion transport |
IDA
IDA: Inferred from direct assay
|
15331542 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| NOT located in Golgi apparatus |
IDA
IDA: Inferred from direct assay
|
15331542 | GOA |
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
15331542 | GOA |
| located in secretory granule |
IDA
IDA: Inferred from direct assay
|
15331542 | GOA |
| located in secretory granule membrane |
IDA
IDA: Inferred from direct assay
|
16984975 | GOA |
SLC30A8 Protein Structure
Cation_efflux: Cation efflux family (77 - 353)
- 0
- 100
- 200
- 300
- 369 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
zinc transporter 8 |
|
SLC30A8 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
SLC30A8 | Q8IWU4 | RELL2 | Homo sapiens | Q8NC24 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | RELL2 | Homo sapiens | Q8NC24 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | RELL2 | Homo sapiens | Q8NC24 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | SLC30A3 | Homo sapiens | Q99726 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | PGRMC2 | Homo sapiens | O15173 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | PGRMC2 | Homo sapiens | O15173 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | HSD17B11 | Homo sapiens | Q8NBQ5 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | HSD17B11 | Homo sapiens | Q8NBQ5 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | HSD17B11 | Homo sapiens | Q8NBQ5 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | ORMDL1 | Homo sapiens | Q9P0S3 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | RMDN3 | Homo sapiens | Q96TC7 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | RMDN3 | Homo sapiens | Q96TC7 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | RMDN3 | Homo sapiens | Q96TC7 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | SPAG4 | Homo sapiens | Q9NPE6 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | SPAG4 | Homo sapiens | Q9NPE6 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | SPAG4 | Homo sapiens | Q9NPE6 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | TMEM237 | Homo sapiens | Q96Q45-2 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | TMEM237 | Homo sapiens | Q96Q45-2 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | TMEM237 | Homo sapiens | Q96Q45-2 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | JSRP1 | Homo sapiens | Q96MG2 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | JSRP1 | Homo sapiens | Q96MG2 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | JSRP1 | Homo sapiens | Q96MG2 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | RTN3 | Homo sapiens | O95197-3 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | RTN3 | Homo sapiens | O95197-3 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | TMEM80 | Homo sapiens | Q96HE8 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | TMEM80 | Homo sapiens | Q96HE8 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | TMEM80 | Homo sapiens | Q96HE8 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | ATP13A1 | Homo sapiens | Q9HD20-3 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | FNDC9 | Homo sapiens | Q8TBE3 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | FNDC9 | Homo sapiens | Q8TBE3 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | FNDC9 | Homo sapiens | Q8TBE3 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | FAXDC2 | Homo sapiens | Q96IV6 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | PKMYT1 | Homo sapiens | Q99640-2 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | TMEM208 | Homo sapiens | Q9BTX3 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | SLC39A2 | Homo sapiens | Q9NP94 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | SLC39A2 | Homo sapiens | Q9NP94 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | SLC39A2 | Homo sapiens | Q9NP94 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | CLDN6 | Homo sapiens | P56747 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | CLDN6 | Homo sapiens | P56747 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | AQP6 | Homo sapiens | Q13520 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | AQP6 | Homo sapiens | Q13520 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | SYS1 | Homo sapiens | Q8N2H4 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | REEP6 | Homo sapiens | Q96HR9-2 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | SCN3B | Homo sapiens | Q9NY72 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | SCN3B | Homo sapiens | Q9NY72 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | SCN3B | Homo sapiens | Q9NY72 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | MUC1 | Homo sapiens | P15941-11 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | MUC1 | Homo sapiens | P15941-11 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | SSMEM1 | Homo sapiens | Q8WWF3 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | SSMEM1 | Homo sapiens | Q8WWF3 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | SSMEM1 | Homo sapiens | Q8WWF3 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | LEUTX | Homo sapiens | A8MZ59 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | LEUTX | Homo sapiens | A8MZ59 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | SLC18A1 | Homo sapiens | P54219-3 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | SLC18A1 | Homo sapiens | P54219-3 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | ERVFRD-1 | Homo sapiens | P60508 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | ERVFRD-1 | Homo sapiens | P60508 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | CPLX4 | Homo sapiens | Q7Z7G2 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | CPLX4 | Homo sapiens | Q7Z7G2 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | GPR42 | Homo sapiens | O15529 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | GPR42 | Homo sapiens | O15529 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | TMEM52B | Homo sapiens | Q4KMG9 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | TMEM52B | Homo sapiens | Q4KMG9 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | FAM209A | Homo sapiens | Q5JX71 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | FAM209A | Homo sapiens | Q5JX71 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | ELOVL4 | Homo sapiens | Q9GZR5 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | ELOVL4 | Homo sapiens | Q9GZR5 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | ELOVL4 | Homo sapiens | Q9GZR5 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | FAM210B | Homo sapiens | Q96KR6 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | FAM210B | Homo sapiens | Q96KR6 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | FAM210B | Homo sapiens | Q96KR6 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | CGRRF1 | Homo sapiens | Q99675 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | CGRRF1 | Homo sapiens | Q99675 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | CGRRF1 | Homo sapiens | Q99675 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | CMTM7 | Homo sapiens | Q96FZ5 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | CD99L2 | Homo sapiens | Q8TCZ2 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | CD99L2 | Homo sapiens | Q8TCZ2 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | CD99L2 | Homo sapiens | Q8TCZ2 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | SFT2D1 | Homo sapiens | Q8WV19 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | PCNA | Homo sapiens | P12004 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | PCNA | Homo sapiens | P12004 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | ZFYVE27 | Homo sapiens | Q5T4F4 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | ZFYVE27 | Homo sapiens | Q5T4F4 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | ZFYVE27 | Homo sapiens | Q5T4F4 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | EBP | Homo sapiens | Q15125 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | EBP | Homo sapiens | Q15125 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | SAR1A | Homo sapiens | Q9NR31 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | SAR1A | Homo sapiens | Q9NR31 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | SAR1A | Homo sapiens | Q9NR31 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | DERL1 | Homo sapiens | Q9BUN8 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | OTULINL | Homo sapiens | Q9NUU6 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | CREB3L1 | Homo sapiens | Q96BA8 | 25910212 | |
|
Intra
|
SLC30A8 | Q8IWU4 | CREB3L1 | Homo sapiens | Q96BA8 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | CREB3L1 | Homo sapiens | Q96BA8 | 25910212 | |
|
Intra
|
SLC30A8 | Q8IWU4 | CREB3L1 | Homo sapiens | Q96BA8 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | CREB3L1 | Homo sapiens | Q96BA8 | 25910212 | |
|
Intra
|
SLC30A8 | Q8IWU4 | CREB3L1 | Homo sapiens | Q96BA8 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | BIK | Homo sapiens | Q13323 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | ARL8B | Homo sapiens | Q9NVJ2 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | TMEM139 | Homo sapiens | Q8IV31 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | TMEM139 | Homo sapiens | Q8IV31 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | TMEM9 | Homo sapiens | Q9P0T7 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | TMEM9 | Homo sapiens | Q9P0T7 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | TMEM9 | Homo sapiens | Q9P0T7 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | THAP4 | Homo sapiens | Q8WY91 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | THAP4 | Homo sapiens | Q8WY91 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | THAP4 | Homo sapiens | Q8WY91 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | HMG20A | Homo sapiens | Q9NP66 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | HMG20A | Homo sapiens | Q9NP66 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | HMG20A | Homo sapiens | Q9NP66 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | BCL2L13 | Homo sapiens | Q9BXK5 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | BCL2L13 | Homo sapiens | Q9BXK5 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | BCL2L13 | Homo sapiens | Q9BXK5 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | YIPF6 | Homo sapiens | Q96EC8 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | YIPF4 | Homo sapiens | Q9BSR8 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | REEP4 | Homo sapiens | Q9H6H4 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | REEP4 | Homo sapiens | Q9H6H4 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | REEP4 | Homo sapiens | Q9H6H4 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | ERGIC3 | Homo sapiens | Q9Y282 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | ERGIC3 | Homo sapiens | Q9Y282 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | ERGIC3 | Homo sapiens | Q9Y282 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | BSND | Homo sapiens | Q8WZ55 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | BSND | Homo sapiens | Q8WZ55 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | BSND | Homo sapiens | Q8WZ55 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | SYT2 | Homo sapiens | Q8N9I0 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | SYT2 | Homo sapiens | Q8N9I0 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | SYT2 | Homo sapiens | Q8N9I0 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | RUSF1 | Homo sapiens | Q96GQ5 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | TMEM14B | Homo sapiens | Q9NUH8 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | ANK1 | Homo sapiens | P16157-17 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | ANK1 | Homo sapiens | P16157-17 | 32296183 | |
|
Intra
|
SLC30A8 | Q8IWU4 | SELENOK | Homo sapiens | Q9Y6D0 | 32296183 | |
|
Cross
|
SLC30A8 | Q8IWU4 | P08563-PRO_0000041304 | Rubella virus | P08563-PRO_0000041304 | 24955142 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Type 2 Diabetes Mellitus |
|
|
| Type 1 Diabetes Mellitus 5 |
|
|
| Pancreatic Cystadenoma |
|
|
| Diabetes Mellitus |
|
|
| Type 1 Diabetes Mellitus 3 |
|
|
| Type 1 Diabetes Mellitus 12 |
|
|
| Insulinoma |
|
|
| Diabetes Mellitus, Ketosis-Prone |
|
|
| Wolfram Syndrome 1 |
|
|
| Type 1 Diabetes Mellitus 15 |
|
|
| Hirata Disease |
|
|
| Gastrointestinal System Benign Neoplasm |
|
|
| Maturity-Onset Diabetes Of The Young |
|
|
| Autoimmune Disease Of Endocrine System |
|
|
| Adrenal Cortical Hypofunction |
|
|
| Wolfram Syndrome |
|
|
| Maturity-Onset Diabetes Of The Young, Type 1 |
|
|
| Maturity-Onset Diabetes Of The Young, Type 3 |
|
|
| Permanent Neonatal Diabetes Mellitus |
|
|
| Celiac Disease 1 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | SLC30A8 | VGNC | VGNC:106932 |
| Felis catus | SLC30A8 | VGNC | VGNC:65314 |
| Macaca mulatta | SLC30A8 | VGNC | VGNC:104494 |
| Rattus norvegicus | SLC30A8 | RGD | RGD:1308282 |
| Canis familiaris | SLC30A8 | VGNC | VGNC:46353 |
| Mus musculus | SLC30A8 | MGD | MGI:2442682 |
| Others | SLC30A8 | NCBI |