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PGRMC2 - progesterone receptor membrane component 2 Gene

Also Known as DG6; PMBP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10424

About PGRMC2

Cytogenetic location: 4q28.2 Genomic coordinates (GRCh38): 4:128,269,242-128,287,813 (from NCBI)

This gene has 8 transcripts (splice variants), 207 orthologues and 3 paralogues. Ubiquitous expression in fat (RPKM 36.7), small intestine (RPKM 30.1) and 25 other tissues.

Summary

Enables heme binding activity. Involved in adipose tissue development. Located in endoplasmic reticulum and nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022]

PGRMC2 Products (1)

mRNA	Protein	Name
NM_006320.6	NP_006311.3	membrane-associated progesterone receptor component 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables heme binding	IDA IDA: Inferred from direct assay	28111073	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	27599036	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in adipose tissue development	IMP IMP: Inferred from mutant phenotype	28111073	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	27754849	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	25468996	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PGRMC2 Protein Structure

Cyt-b5

0
100
200
223 a.a.

Protein Preferred Names	Protein Names
membrane-associated progesterone receptor component 2	progesterone membrane binding protein

PGRMC2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PGRMC2	O15173	SLC30A8	Homo sapiens	Q8IWU4	Validated Y2H	32296183
Intra	PGRMC2	O15173	SLC39A13	Homo sapiens	Q96H72	Validated Y2H	32296183
Intra	PGRMC2	O15173	ORMDL1	Homo sapiens	Q9P0S3	Validated Y2H	32296183
Intra	PGRMC2	O15173	VAPA	Homo sapiens	Q9P0L0	Anti Tag CoIP	35271311
Intra	PGRMC2	O15173	VAPA	Homo sapiens	Q9P0L0	Validated Y2H	32296183
Intra	PGRMC2	O15173	FA2H	Homo sapiens	Q7L5A8	Validated Y2H	32296183
Intra	PGRMC2	O15173	GPR151	Homo sapiens	Q8TDV0	Validated Y2H	32296183
Intra	PGRMC2	O15173	TMEM86A	Homo sapiens	Q8N2M4	Validated Y2H	32296183
Intra	PGRMC2	O15173	LPAR3	Homo sapiens	Q9UBY5	Validated Y2H	32296183
Intra	PGRMC2	O15173	FAXDC2	Homo sapiens	Q96IV6	Validated Y2H	32296183
Intra	PGRMC2	O15173	SLC16A13	Homo sapiens	Q7RTY0	Validated Y2H	32296183
Intra	PGRMC2	O15173	AQP10	Homo sapiens	Q96PS8	Validated Y2H	32296183
Intra	PGRMC2	O15173	SMPD2	Homo sapiens	O60906	Validated Y2H	32296183
Intra	PGRMC2	O15173	DGAT2L6	Homo sapiens	Q6ZPD8	Validated Y2H	32296183
Intra	PGRMC2	O15173	TMEM107	Homo sapiens	Q6UX40	Validated Y2H	32296183
Intra	PGRMC2	O15173	TAS2R19	Homo sapiens	P59542	Validated Y2H	32296183
Intra	PGRMC2	O15173	TMEM208	Homo sapiens	Q9BTX3	Validated Y2H	32296183
Intra	PGRMC2	O15173	ST6GAL2	Homo sapiens	Q96JF0-2	Validated Y2H	32296183
Intra	PGRMC2	O15173	TMEM187	Homo sapiens	Q14656	Validated Y2H	32296183
Intra	PGRMC2	O15173	STX3	Homo sapiens	Q13277	Validated Y2H	32296183
Intra	PGRMC2	O15173	CYP4F2	Homo sapiens	P78329	Validated Y2H	32296183
Intra	PGRMC2	O15173	GET3	Homo sapiens	O43681	Validated Y2H	32296183
Intra	PGRMC2	O15173	TMEM86B	Homo sapiens	Q8N661	Validated Y2H	32296183
Intra	PGRMC2	O15173	ITPRIP	Homo sapiens	Q8IWB1	Anti Tag CoIP	35271311
Intra	PGRMC2	O15173	ITPRIP	Homo sapiens	Q8IWB1	Validated Y2H	32296183
Intra	PGRMC2	O15173	ITGAM	Homo sapiens	P11215	Validated Y2H	32296183
Intra	PGRMC2	O15173	COX20	Homo sapiens	Q5RI15	Validated Y2H	32296183
Intra	PGRMC2	O15173	PMP22	Homo sapiens	Q01453	Validated Y2H	32296183
Intra	PGRMC2	O15173	ZDHHC21	Homo sapiens	Q8IVQ6	Validated Y2H	32296183
Intra	PGRMC2	O15173	TMEM60	Homo sapiens	Q9H2L4	Validated Y2H	32296183
Intra	PGRMC2	O15173	MFHAS1	Homo sapiens	Q9Y4C4	Protein Array	29513927
Intra	PGRMC2	O15173	GHITM	Homo sapiens	Q9H3K2	Validated Y2H	32296183
Intra	PGRMC2	O15173	TECR	Homo sapiens	Q9NZ01	Validated Y2H	32296183
Intra	PGRMC2	O15173	BAG4	Homo sapiens	O95429	Y2H Prey Pooling	32296183
Intra	PGRMC2	O15173	BAG4	Homo sapiens	O95429	Validated Y2H	32296183
Intra	PGRMC2	O15173	BAG4	Homo sapiens	O95429	Y2H Array	32296183
Intra	PGRMC2	O15173	SFXN1	Homo sapiens	Q9H9B4	Validated Y2H	32296183
Intra	PGRMC2	O15173	RNF8	Homo sapiens	O76064	Validated Y2H	32296183
Intra	PGRMC2	O15173	TSPAN2	Homo sapiens	O60636	Validated Y2H	32296183
Intra	PGRMC2	O15173	PLLP	Homo sapiens	Q9Y342	Validated Y2H	32296183
Intra	PGRMC2	O15173	MFSD5	Homo sapiens	Q6N075	Validated Y2H	32296183
Intra	PGRMC2	O15173	MFSD5	Homo sapiens	Q6N075	Y2H Array	32296183
Intra	PGRMC2	O15173	DHRSX	Homo sapiens	Q8N5I4	Validated Y2H	32296183
Intra	PGRMC2	O15173	FXYD6	Homo sapiens	Q9H0Q3	Validated Y2H	32296183
Intra	PGRMC2	O15173	TF	Homo sapiens	P02787	Validated Y2H	32296183
Cross	PGRMC2	O15173	Fech	Mus musculus	P22315	Anti Tag CoIP	27599036
Intra	PGRMC2	O15173	ZFPL1	Homo sapiens	O95159	Validated Y2H	32296183
Intra	PGRMC2	O15173	TMEM19	Homo sapiens	Q96HH6	Validated Y2H	32296183
Intra	PGRMC2	O15173	MALL	Homo sapiens	Q13021	Validated Y2H	32296183
Intra	PGRMC2	O15173	YIPF2	Homo sapiens	Q9BWQ6	Validated Y2H	32296183
Intra	PGRMC2	O15173	C5	Homo sapiens	P01031	Validated Y2H	32296183
Intra	PGRMC2	O15173	RUSF1	Homo sapiens	Q96GQ5	Validated Y2H	32296183
Intra	PGRMC2	O15173	PEX16	Homo sapiens	Q9Y5Y5	Validated Y2H	32296183
Intra	PGRMC2	O15173	SLC9B2	Homo sapiens	Q86UD5	Validated Y2H	32296183
Intra	PGRMC2	O15173	SLC38A1	Homo sapiens	Q9H2H9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Schizophrenia 12	Sczd12 Schizophrenia Susceptibility Locus, Chromosome 1p-Related
Achalasia-Addisonianism-Alacrima Syndrome	Allgrove Syndrome Triple-A Syndrome Achalasia-Addisonianism-Alacrimia Syndrome Alacrima-Achalasia-Adrenal Insufficiency Neurologic Disorder Triple A Syndrome Aaa Syndrome AAAS Glucocorticoid Deficiency With Achalasia Glucocorticoid Deficiency And Achalasia Addisonian-Achalasia Syndrome Hypoadrenalism With Achalasia Alacrima-Achalasia-Addisonianism Aaa Acth-Resistant Adrenal Insufficiency, Achalasia And Alacrima Achalasia Addisonianism Alacrimia Syndrome Achalasia Alacrima Syndrome Addisonian Achalasia Syndrome Achalasia-Addisonian Syndrome Achalasia-Alacrima Syndrome 2a Syndrome 3a Syndrome 4a Syndrome Adrenal Insufficiency-Achalasia-Alacrima Syndrome Double A Syndrome Quaternary A Syndrome Acth-Resistant Adrenal Insufficiency With Achalasia And Alacrima Allgrove'S Syndrome Adrenal Gland Hypofunction Adrenal Cortical Hypofunction
Clivus Chordoma	Chordoma Of Clivus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115625	AG-205		99%	Unkown
HY-186011	CPAG-1	Activator	/	Unkown
HY-RS10400	PGRMC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21906	Pgrmc2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28423	Pgrmc2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PGRMC2	RGD	RGD:1308804
Bos taurus	PGRMC2	VGNC	VGNC:32802
Canis familiaris	PGRMC2	VGNC	VGNC:44471
Mus musculus	PGRMC2	MGD	MGI:1918054
Felis catus	PGRMC2	VGNC	VGNC:64126
Macaca mulatta	PGRMC2	VGNC	VGNC:107190
Others	PGRMC2	NCBI