ITPRIP - inositol 1,4,5-trisphosphate receptor interacting protein Gene

Also Known as DANGER; KIAA1754; bA127L20; bA127L20.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 85450

About ITPRIP

This gene has 5 transcripts (splice variants), 234 orthologues and 9 paralogues. Broad expression in bone marrow (RPKM 60.0), esophagus (RPKM 14.1) and 17 other tissues.

Summary

This gene encodes a membrane-associated protein that binds the inositol 1,4,5-trisphosphate receptor (ITPR). The encoded protein enhances the sensitivity of ITPR to intracellular calcium signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

ITPRIP Products (3)

mRNA Protein Name
NM_001272012.2 NP_001258941.1 inositol 1,4,5-trisphosphate receptor-interacting protein precursor
NM_001272013.2 NP_001258942.1 inositol 1,4,5-trisphosphate receptor-interacting protein precursor
NM_033397.4 NP_203755.1 inositol 1,4,5-trisphosphate receptor-interacting protein precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25464930 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITPRIP Protein Structure

Mab-21

Mab-21: Mab-21 protein (347 - 479)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 547 a.a.
Protein Preferred Names Protein Names

inositol 1,4,5-trisphosphate receptor-interacting protein

  • inositol 1,4,5-triphosphate receptor-interacting protein

ITPRIP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ITPRIP Q8IWB1 PGRMC2 Homo sapiens O15173
Y2H Prey Pooling
32296183
Intra
ITPRIP Q8IWB1 PGRMC2 Homo sapiens O15173
Y2H Array
32296183
Intra
ITPRIP Q8IWB1 NLGN3 Homo sapiens Q9NZ94-2
Y2H
25464930
Intra
ITPRIP Q8IWB1 NLGN3 Homo sapiens Q9NZ94-2
Anti Tag CoIP
25464930
Intra
ITPRIP Q8IWB1 NLGN3 Homo sapiens Q9NZ94-2
Confocal
25464930
Intra
ITPRIP Q8IWB1 RASSF3 Homo sapiens Q86WH2
Y2H Prey Pooling
32296183
Intra
ITPRIP Q8IWB1 RASSF3 Homo sapiens Q86WH2
Y2H Array
32296183
Intra
ITPRIP Q8IWB1 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
Intra
ITPRIP Q8IWB1 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
Intra
ITPRIP Q8IWB1 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06995 ITPRIP Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ITPRIP RGD RGD:6488464
Felis catus ITPRIP VGNC VGNC:82413
Mus musculus ITPRIP MGD MGI:3042776
Bos taurus ITPRIP VGNC VGNC:30349
Canis familiaris ITPRIP VGNC VGNC:52996
Macaca mulatta ITPRIP VGNC VGNC:81424
Others ITPRIP NCBI