TSPAN2 - tetraspanin 2 Gene

Also Known as NET3; TSN2; TSPAN-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10100

About TSPAN2

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:115,048,011-115,089,503 (from NCBI)

This gene has 4 transcripts (splice variants), 269 orthologues and 32 paralogues. Broad expression in endometrium (RPKM 16.8), urinary bladder (RPKM 10.7) and 19 other tissues.

Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

TSPAN2 Products (3)

mRNA	Protein	Name
NM_001308315.2	NP_001295244.1	tetraspanin-2 isoform 2
NM_001308316.2	NP_001295245.1	tetraspanin-2 isoform 3
NM_005725.6	NP_005716.2	tetraspanin-2 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25814554	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSPAN2 Protein Structure

Tetraspannin

0
100
200
221 a.a.

Protein Preferred Names	Protein Names
tetraspanin-2	new EST tetraspan 3

TSPAN2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TSPAN2	O60636	SLC30A8	Homo sapiens	Q8IWU4	Y2H Prey Pooling	32296183
Intra	TSPAN2	O60636	SLC30A8	Homo sapiens	Q8IWU4	Validated Y2H	32296183
Intra	TSPAN2	O60636	SLC30A8	Homo sapiens	Q8IWU4	Y2H Array	32296183
Intra	TSPAN2	O60636	PGRMC2	Homo sapiens	O15173	Y2H Prey Pooling	32296183
Intra	TSPAN2	O60636	PGRMC2	Homo sapiens	O15173	Y2H Array	32296183
Intra	TSPAN2	O60636	BSCL2	Homo sapiens	J3KQ12	Y2H Array	32296183
Intra	TSPAN2	O60636	BSCL2	Homo sapiens	J3KQ12	Y2H Prey Pooling	32296183
Intra	TSPAN2	O60636	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
Intra	TSPAN2	O60636	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
Intra	TSPAN2	O60636	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
Intra	TSPAN2	O60636	MFF	Homo sapiens	Q9GZY8-5	Validated Y2H	32296183
Intra	TSPAN2	O60636	MFF	Homo sapiens	Q9GZY8-5	Y2H Array	32296183
Intra	TSPAN2	O60636	MFF	Homo sapiens	Q9GZY8-5	Y2H Prey Pooling	32296183
Intra	TSPAN2	O60636	DCBLD2	Homo sapiens	Q96PD2-2	Validated Y2H	32296183
Intra	TSPAN2	O60636	DCBLD2	Homo sapiens	Q96PD2-2	Y2H Array	32296183
Intra	TSPAN2	O60636	DCBLD2	Homo sapiens	Q96PD2-2	Y2H Prey Pooling	32296183
Intra	TSPAN2	O60636	ATP1B4	Homo sapiens	Q9UN42	Validated Y2H	32296183
Intra	TSPAN2	O60636	ATP1B4	Homo sapiens	Q9UN42	Y2H Array	32296183
Intra	TSPAN2	O60636	ATP1B4	Homo sapiens	Q9UN42	Y2H Prey Pooling	32296183
Intra	TSPAN2	O60636	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	TSPAN2	O60636	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	TSPAN2	O60636	SCN3B	Homo sapiens	Q9NY72	Validated Y2H	32296183
Intra	TSPAN2	O60636	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Array	32296183
Intra	TSPAN2	O60636	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Prey Pooling	32296183
Intra	TSPAN2	O60636	SLC35C2	Homo sapiens	Q9NQQ7-3	Validated Y2H	32296183
Intra	TSPAN2	O60636	TSPAN31	Homo sapiens	Q12999	Y2H Prey Pooling	32296183
Intra	TSPAN2	O60636	TSPAN31	Homo sapiens	Q12999	Validated Y2H	32296183
Intra	TSPAN2	O60636	TSPAN31	Homo sapiens	Q12999	Y2H Array	32296183
Intra	TSPAN2	O60636	CLEC14A	Homo sapiens	Q86T13	Y2H Prey Pooling	32296183
Intra	TSPAN2	O60636	CLEC14A	Homo sapiens	Q86T13	Y2H Array	32296183
Intra	TSPAN2	O60636	CLEC14A	Homo sapiens	Q86T13	Validated Y2H	32296183
Intra	TSPAN2	O60636	KDELR3	Homo sapiens	O43731-2	Y2H Array	32296183
Intra	TSPAN2	O60636	KDELR3	Homo sapiens	O43731-2	Y2H Prey Pooling	32296183
Intra	TSPAN2	O60636	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	TSPAN2	O60636	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	TSPAN2	O60636	SLC10A6	Homo sapiens	Q3KNW5	Validated Y2H	32296183
Intra	TSPAN2	O60636	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	TSPAN2	O60636	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	TSPAN2	O60636	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	TSPAN2	O60636	CLDN5	Homo sapiens	O00501	Y2H Prey Pooling	32296183
Intra	TSPAN2	O60636	CLDN5	Homo sapiens	O00501	Y2H Array	32296183
Intra	TSPAN2	O60636	TMEM130	Homo sapiens	Q8N3G9	Validated Y2H	32296183
Intra	TSPAN2	O60636	TMEM130	Homo sapiens	Q8N3G9	Y2H Prey Pooling	32296183
Intra	TSPAN2	O60636	TMEM130	Homo sapiens	Q8N3G9	Y2H Array	32296183
Intra	TSPAN2	O60636	RNF19B	Homo sapiens	Q6ZMZ0	Validated Y2H	32296183
Intra	TSPAN2	O60636	RNF19B	Homo sapiens	Q6ZMZ0	Y2H Array	32296183
Intra	TSPAN2	O60636	RNF19B	Homo sapiens	Q6ZMZ0	Y2H Prey Pooling	32296183
Intra	TSPAN2	O60636	F13A1	Homo sapiens	P00488	Y2H Array	32814053
Intra	TSPAN2	O60636	F13A1	Homo sapiens	P00488	Y2H Pooling	32814053
Intra	TSPAN2	O60636	F13A1	Homo sapiens	P00488	Validated Y2H	32814053
Intra	TSPAN2	O60636	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	TSPAN2	O60636	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	TSPAN2	O60636	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	TSPAN2	O60636	ABHD16A	Homo sapiens	O95870	Y2H Array	32296183
Intra	TSPAN2	O60636	ABHD16A	Homo sapiens	O95870	Y2H Prey Pooling	32296183
Intra	TSPAN2	O60636	ABHD16A	Homo sapiens	O95870	Validated Y2H	32296183
Intra	TSPAN2	O60636	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	TSPAN2	O60636	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	TSPAN2	O60636	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	TSPAN2	O60636	ZFYVE27	Homo sapiens	Q5T4F4	Validated Y2H	32296183
Intra	TSPAN2	O60636	ZFYVE27	Homo sapiens	Q5T4F4	Y2H Array	32296183
Intra	TSPAN2	O60636	ZFYVE27	Homo sapiens	Q5T4F4	Y2H Prey Pooling	32296183
Intra	TSPAN2	O60636	IFNGR2	Homo sapiens	P38484	Y2H Prey Pooling	32296183
Intra	TSPAN2	O60636	IFNGR2	Homo sapiens	P38484	Validated Y2H	32296183
Intra	TSPAN2	O60636	IFNGR2	Homo sapiens	P38484	Y2H Array	32296183
Intra	TSPAN2	O60636	FKBP7	Homo sapiens	Q9Y680	Validated Y2H	32296183
Intra	TSPAN2	O60636	FKBP7	Homo sapiens	Q9Y680	Y2H Array	32296183
Intra	TSPAN2	O60636	FKBP7	Homo sapiens	Q9Y680	Y2H Prey Pooling	32296183
Intra	TSPAN2	O60636	GRB2	Homo sapiens	P62993	Peptide Array	25814554
Intra	TSPAN2	O60636	GRB2	Homo sapiens	P62993	BiFC	25814554
Intra	TSPAN2	O60636	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	TSPAN2	O60636	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	TSPAN2	O60636	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	TSPAN2	O60636	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	TSPAN2	O60636	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	TSPAN2	O60636	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	TSPAN2	O60636	MGST3	Homo sapiens	O14880	Y2H Array	32296183
Intra	TSPAN2	O60636	MGST3	Homo sapiens	O14880	Y2H Prey Pooling	32296183
Intra	TSPAN2	O60636	VSIR	Homo sapiens	Q9H7M9	Validated Y2H	32296183
Intra	TSPAN2	O60636	VSIR	Homo sapiens	Q9H7M9	Y2H Prey Pooling	32296183
Intra	TSPAN2	O60636	VSIR	Homo sapiens	Q9H7M9	Y2H Array	32296183
Intra	TSPAN2	O60636	LEPROTL1	Homo sapiens	O95214	Validated Y2H	32296183
Intra	TSPAN2	O60636	LEPROTL1	Homo sapiens	O95214	Y2H Prey Pooling	32296183
Intra	TSPAN2	O60636	LEPROTL1	Homo sapiens	O95214	Y2H Array	32296183
Intra	TSPAN2	O60636	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
Intra	TSPAN2	O60636	REEP4	Homo sapiens	Q9H6H4	Validated Y2H	32296183
Intra	TSPAN2	O60636	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
Intra	TSPAN2	O60636	CD79A	Homo sapiens	P11912	Validated Y2H	32296183
Intra	TSPAN2	O60636	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	TSPAN2	O60636	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	TSPAN2	O60636	PIK3R3	Homo sapiens	Q92569	Pull Down	25814554
Intra	TSPAN2	O60636	PIK3R3	Homo sapiens	Q92569	BiFC	25814554
Intra	TSPAN2	O60636	PIK3R3	Homo sapiens	Q92569	Peptide Array	25814554
Intra	TSPAN2	O60636	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	TSPAN2	O60636	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	TSPAN2	O60636	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Migraine, Familial Hemiplegic, 2	FHM2 Mhp2 Migraine, Familial Basilar Familial Hemiplegic Migraine 2 Familial Hemiplegic Migraine-2 Familiar Basilar Migraine Migraine, Hemiplegic, Familial, Type 2
Vasculopathy, Retinal, With Cerebral Leukoencephalopathy And Systemic Manifestations	Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations Crv Rvcl Rvcl-S Vasculopathy, Retinal, With Cerebral Leukodystrophy Retinopathy, Vascular, With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena Retinal Vasculopathy With Cerebral Leukodystrophy Retinal Vasculopathy And Cerebral Leukoencephalopathy Hereditary Vascular Retinopathy Hvr RVCLS Cerebroretinal Vasculopathy, Hereditary Cerebroretinal Vasculopathy Herns Vasculopathy, Retinal, With Cerebral Leukodystrophy, Formerly Hereditary Cerebroretinal Vasculopathy Hereditary Endotheliopathy, Retinopathy, Nephropathy, Stroke Hereditary Systemic Angiopathy Hsa Retinal Vasculopathy With Cerebral Leukodystrophy With Systemic Manifestations Adrvcl Autosomal Dominant Retinal Vasculopathy With Cerebral Leukodystrophy Hereditary Endotheliopathy With Retinopathy-Nephropathy-Stroke Vascular Retinopathy With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena
Clonorchiasis	Oriental Liver Fluke Disease Clonorchis Liver Infection Clonorchiosis Chinese Liver Fluke Disease Hepatic Distomiasis Due To Clonorchis Sinensis Infection Due To Clonorchis Sinensis Hepatic Distomiasis Hepatic Distomatosis Chinese Liver Fluke Disorder Oriental Liver Fluke Disorder Clonorchis Infestation Chinese Liver Fluke Infestation Liver Fluke Disease Due To Clonorchis Sinensis Oriental Liver Fluke Infestation
Migraine, Familial Hemiplegic, 3	FHM3 Familial Hemiplegic Migraine 3 Mhp3 Migraine, Hemiplegic, Familial, Type 3
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15165	TSPAN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17620	Tspan2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24080	Tspan2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TSPAN2	RGD	RGD:620982
Bos taurus	TSPAN2	VGNC	VGNC:36435
Macaca mulatta	TSPAN2	VGNC	VGNC:79264
Felis catus	TSPAN2	VGNC	VGNC:66630
Mus musculus	TSPAN2	MGD	MGI:1917997
Canis familiaris	TSPAN2	VGNC	VGNC:47918
Others	TSPAN2	NCBI