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RNF19B - ring finger protein 19B Gene

Also Known as NKLAM; IBRDC3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 127544

About RNF19B

Cytogenetic location: 1p35.1 Genomic coordinates (GRCh38): 1:32,929,036-32,964,809 (from NCBI)

This gene has 3 transcripts (splice variants), 204 orthologues and 9 paralogues. Broad expression in testis (RPKM 31.7), bone marrow (RPKM 15.6) and 23 other tissues.

Summary

This gene encodes a multi-pass membrane protein containing two RING-type and one IBR-type zinc finger motifs. The encoded protin is an E3 ubiquitin-protein Ligase that plays a role in the cytotoxic effects of natural killer (NK) cells. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes X and Y in a possible pseudoautosomal region. [provided by RefSeq, Jul 2014]

RNF19B Products (3)

mRNA	Protein	Name
NM_001127361.3	NP_001120833.1	E3 ubiquitin-protein ligase RNF19B isoform b
NM_001300826.2	NP_001287755.1	E3 ubiquitin-protein ligase RNF19B isoform c
NM_153341.4	NP_699172.2	E3 ubiquitin-protein ligase RNF19B isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16709802	GOA
enables ubiquitin binding	IDA IDA: Inferred from direct assay	27485036	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	27485036	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein autoubiquitination	IDA IDA: Inferred from direct assay	27485036	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	27485036	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF19B Protein Structure

IBR

0
200
400
600
732 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase RNF19B	IBR domain-containing protein 3

RNF19B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RNF19B	Q6ZMZ0	SLC30A3	Homo sapiens	Q99726	Validated Y2H	32296183
Intra	RNF19B	Q6ZMZ0	CLEC1A	Homo sapiens	Q8NC01	Validated Y2H	32296183
Intra	RNF19B	Q6ZMZ0	TMEM208	Homo sapiens	Q9BTX3	Validated Y2H	32296183
Intra	RNF19B	Q6ZMZ0	UBE2L6	Homo sapiens	O14933	Anti Bait CoIP	16709802
Intra	RNF19B	Q6ZMZ0	UBE2L6	Homo sapiens	O14933	Anti Tag CoIP	16709802
Intra	RNF19B	Q6ZMZ0	UCKL1	Homo sapiens	Q9NWZ5	Anti Tag CoIP	16709802
Intra	RNF19B	Q6ZMZ0	SACM1L	Homo sapiens	Q9NTJ5	Validated Y2H	32296183
Intra	RNF19B	Q6ZMZ0	AP1M1	Homo sapiens	Q9BXS5	Anti Tag CoIP	28514442
Intra	RNF19B	Q6ZMZ0	AP1M1	Homo sapiens	Q9BXS5	Validated Y2H	32296183
Intra	RNF19B	Q6ZMZ0	AP1M1	Homo sapiens	Q9BXS5	Anti Tag CoIP	33961781
Intra	RNF19B	Q6ZMZ0	GIMAP5	Homo sapiens	Q96F15	Validated Y2H	32296183
Intra	RNF19B	Q6ZMZ0	UBE2L3	Homo sapiens	P68036	Anti Tag CoIP	16709802
Intra	RNF19B	Q6ZMZ0	TMEM100	Homo sapiens	Q9NV29	Validated Y2H	32296183
Intra	RNF19B	Q6ZMZ0	SEC22A	Homo sapiens	Q96IW7	Validated Y2H	32296183
Intra	RNF19B	Q6ZMZ0	SELENOK	Homo sapiens	Q9Y6D0	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12073	RNF19B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RNF19B	VGNC	VGNC:80344
Mus musculus	RNF19B	MGD	MGI:1922484
Bos taurus	RNF19B	VGNC	VGNC:34045
Rattus norvegicus	RNF19B	RGD	RGD:1305470
Macaca mulatta	RNF19B	VGNC	VGNC:106488
Canis familiaris	RNF19B	VGNC	VGNC:45651
Others	RNF19B	NCBI