GIMAP5 - GTPase, IMAP family member 5 Gene

Homo sapiens

Also known as IAN4; IAN5; IROD; IAN-5; IMAP3; NCPH2; HIMAP3; IAN4L1

Gene ID: 55340 | Gene type: protein coding

About GIMAP5

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:150,737,418-150,743,646 (from NCBI)

This gene has 7 transcripts (splice variants), 282 orthologues, 7 paralogues and is associated with 1 phenotype. Broad expression in lymph node (RPKM 61.1), spleen (RPKM 41.6) and 21 other tissues.

Summary

This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene encodes an antiapoptotic protein that functions in T-cell survival. Polymorphisms in this gene are associated with systemic lupus erythematosus. Read-through transcription exists between this gene and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1) gene. [provided by RefSeq, Dec 2010]

GIMAP5 Products(1)

mRNA	Protein	Name
NM_018384.5	NP_060854.2	GTPase IMAP family member 5

GIMAP5 Protein Structure

AIG1

0
100
200
307 a.a.

Protein Preferred Names

Protein Names

GTPase IMAP family member 5

immune associated nucleotide 4 like 1

Related Diseases

Diseases

Alias

Portal Hypertension, Noncirrhotic, 2

NCPH2

Portal Hypertension, Non-Cirrhotic, 2

Portal Hypertension

Hypertension, Portal	Hypertension Portal
Pht - [Portal Hypertension]	Portal Htn

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Lymphopenia

Lymphocytopenia

Type 1 Diabetes Mellitus 8

Diabetes Mellitus, Insulin-Dependent, 8	Iddm8
Insulin-Dependent Diabetes Mellitus 8	T1D8
Insulin-Dependent Diabetes Mellitus-8

Wolfram Syndrome 2

WFS2

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Pancytopenia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05425	GIMAP5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GIMAP5	RGD	RGD:628871
Mus musculus	GIMAP5	MGD	MGI:2442232

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