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CD53 - CD53 molecule Gene

Also Known as MOX44; TSPAN25

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 963

About CD53

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:110,871,210-110,899,922 (from NCBI)

This gene has 6 transcripts (splice variants), 223 orthologues and 32 paralogues. Biased expression in lymph node (RPKM 181.8), appendix (RPKM 156.6) and 12 other tissues.

Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

CD53 Products (3)

mRNA	Protein	Name
NM_000560.4	NP_000551.1	leukocyte surface antigen CD53 isoform 1
NM_001040033.2	NP_001035122.1	leukocyte surface antigen CD53 isoform 1
NM_001320638.2	NP_001307567.1	leukocyte surface antigen CD53 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21930792	GOA
enables protein-membrane adaptor activity	IDA IDA: Inferred from direct assay	35767951	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in receptor clustering	IDA IDA: Inferred from direct assay	35767951	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in immunological synapse	IDA IDA: Inferred from direct assay	21930792	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	28487417	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD53 Protein Structure

Tetraspannin

0
100
200
219 a.a.

Protein Preferred Names	Protein Names
leukocyte surface antigen CD53	CD53 antigen

CD53 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CD53	P19397	LSMEM1	Homo sapiens	Q8N8F7	Validated Y2H	32296183
Intra	CD53	P19397	SMAGP	Homo sapiens	Q0VAQ4	Validated Y2H	32296183
Intra	CD53	P19397	RPRM	Homo sapiens	Q9NS64	Validated Y2H	32296183
Intra	CD53	P19397	TMEM128	Homo sapiens	Q5BJH2-2	Validated Y2H	32296183
Intra	CD53	P19397	TMEM237	Homo sapiens	Q96Q45-2	Validated Y2H	32296183
Intra	CD53	P19397	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	CD53	P19397	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	CD53	P19397	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	CD53	P19397	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	CD53	P19397	ARL13B	Homo sapiens	Q3SXY8	Validated Y2H	32296183
Intra	CD53	P19397	GPR108	Homo sapiens	Q9NPR9	Validated Y2H	32296183
Intra	CD53	P19397	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	CD53	P19397	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	CD53	P19397	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	CD53	P19397	STX2	Homo sapiens	P32856-2	Y2H Prey Pooling	32296183
Intra	CD53	P19397	STX2	Homo sapiens	P32856-2	Validated Y2H	32296183
Intra	CD53	P19397	STX2	Homo sapiens	P32856-2	Y2H Array	32296183
Intra	CD53	P19397	AIG1	Homo sapiens	Q9NVV5-2	Validated Y2H	32296183
Intra	CD53	P19397	SNORC	Homo sapiens	Q6UX34	Validated Y2H	32296183
Intra	CD53	P19397	CLEC7A	Homo sapiens	Q9BXN2-6	Validated Y2H	32296183
Intra	CD53	P19397	TRAM1L1	Homo sapiens	Q8N609	Validated Y2H	32296183
Intra	CD53	P19397	CTXN3	Homo sapiens	Q4LDR2	Validated Y2H	32296183
Intra	CD53	P19397	LPAR3	Homo sapiens	Q9UBY5	Validated Y2H	32296183
Intra	CD53	P19397	C1QL4	Homo sapiens	Q86Z23	Y2H Array	32296183
Intra	CD53	P19397	C1QL4	Homo sapiens	Q86Z23	Validated Y2H	32296183
Intra	CD53	P19397	TMEM97	Homo sapiens	Q5BJF2	Validated Y2H	32296183
Intra	CD53	P19397	VSTM1	Homo sapiens	Q6UX27-3	Validated Y2H	32296183
Intra	CD53	P19397	TMEM229B	Homo sapiens	Q8NBD8	Validated Y2H	32296183
Intra	CD53	P19397	TSPO2	Homo sapiens	Q5TGU0	Validated Y2H	32296183
Intra	CD53	P19397	COL4A5	Homo sapiens	P29400-2	Validated Y2H	32296183
Intra	CD53	P19397	CLDN19	Homo sapiens	Q8N6F1-2	Validated Y2H	32296183
Intra	CD53	P19397	MS4A3	Homo sapiens	Q96HJ5	Y2H Prey Pooling	32296183
Intra	CD53	P19397	MS4A3	Homo sapiens	Q96HJ5	Validated Y2H	32296183
Intra	CD53	P19397	MS4A3	Homo sapiens	Q96HJ5	Y2H Array	32296183
Intra	CD53	P19397	ASGR2	Homo sapiens	P07307-3	Y2H Array	32296183
Intra	CD53	P19397	ASGR2	Homo sapiens	P07307-3	Y2H Prey Pooling	32296183
Intra	CD53	P19397	CNIH2	Homo sapiens	Q6PI25	Validated Y2H	32296183
Intra	CD53	P19397	SLC35A1	Homo sapiens	P78382	Validated Y2H	32296183
Intra	CD53	P19397	ST6GAL2	Homo sapiens	Q96JF0-2	Validated Y2H	32296183
Intra	CD53	P19397	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	CD53	P19397	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	CD53	P19397	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	CD53	P19397	CD302	Homo sapiens	Q8IX05	Validated Y2H	32296183
Intra	CD53	P19397	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	CD53	P19397	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	CD53	P19397	KIR3DL3	Homo sapiens	Q8N743	Y2H Prey Pooling	32296183
Intra	CD53	P19397	KIR3DL3	Homo sapiens	Q8N743	Validated Y2H	32296183
Intra	CD53	P19397	KIR3DL3	Homo sapiens	Q8N743	Y2H Array	32296183
Intra	CD53	P19397	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	CD53	P19397	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	CD53	P19397	GJA8	Homo sapiens	P48165	Validated Y2H	32296183
Intra	CD53	P19397	EFNA5	Homo sapiens	P52803	Validated Y2H	32296183
Intra	CD53	P19397	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	CD53	P19397	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	CD53	P19397	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	CD53	P19397	GET1	Homo sapiens	O00258	Y2H Prey Pooling	32296183
Intra	CD53	P19397	GET1	Homo sapiens	O00258	Y2H Array	32296183
Intra	CD53	P19397	TMEM86B	Homo sapiens	Q8N661	Validated Y2H	32296183
Intra	CD53	P19397	CYBC1	Homo sapiens	Q9BQA9	Validated Y2H	32296183
Intra	CD53	P19397	CYBC1	Homo sapiens	Q9BQA9	Y2H Array	32296183
Intra	CD53	P19397	CYBC1	Homo sapiens	Q9BQA9	Y2H Prey Pooling	32296183
Intra	CD53	P19397	UBIAD1	Homo sapiens	Q9Y5Z9	Validated Y2H	32296183
Intra	CD53	P19397	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	32296183
Intra	CD53	P19397	TMEM140	Homo sapiens	Q9NV12	Validated Y2H	32296183
Intra	CD53	P19397	PMP22	Homo sapiens	Q01453	Validated Y2H	32296183
Intra	CD53	P19397	TMEM60	Homo sapiens	Q9H2L4	Validated Y2H	32296183
Intra	CD53	P19397	NKG7	Homo sapiens	Q16617	Validated Y2H	32296183
Intra	CD53	P19397	SAR1A	Homo sapiens	Q9NR31	Y2H Prey Pooling	32296183
Intra	CD53	P19397	SAR1A	Homo sapiens	Q9NR31	Y2H Array	32296183
Intra	CD53	P19397	SAR1A	Homo sapiens	Q9NR31	Validated Y2H	32296183
Intra	CD53	P19397	MAL	Homo sapiens	P21145	Validated Y2H	32296183
Intra	CD53	P19397	EMP1	Homo sapiens	P54849	Validated Y2H	32296183
Intra	CD53	P19397	CLCN7	Homo sapiens	P51798	Validated Y2H	32296183
Intra	CD53	P19397	SLC7A14	Homo sapiens	Q8TBB6	Y2H Prey Pooling	32296183
Intra	CD53	P19397	SLC7A14	Homo sapiens	Q8TBB6	Validated Y2H	32296183
Intra	CD53	P19397	SLC7A14	Homo sapiens	Q8TBB6	Y2H Array	32296183
Intra	CD53	P19397	PLP2	Homo sapiens	Q04941	Validated Y2H	32296183
Intra	CD53	P19397	GIMAP5	Homo sapiens	Q96F15	Validated Y2H	32296183
Intra	CD53	P19397	ccsb orf id: 13502	Homo sapiens	EBI-23641393	Y2H Array	32296183
Intra	CD53	P19397	PLN	Homo sapiens	P26678	Validated Y2H	32296183
Intra	CD53	P19397	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	CD53	P19397	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	CD53	P19397	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	CD53	P19397	BIK	Homo sapiens	Q13323	Y2H Array	32296183
Intra	CD53	P19397	BIK	Homo sapiens	Q13323	Y2H Prey Pooling	32296183
Intra	CD53	P19397	BIK	Homo sapiens	Q13323	Validated Y2H	32296183
Intra	CD53	P19397	ERG28	Homo sapiens	Q9UKR5	Validated Y2H	32296183
Intra	CD53	P19397	IGFBP5	Homo sapiens	P24593	Validated Y2H	32296183
Intra	CD53	P19397	ATP6V0C	Homo sapiens	P27449	Validated Y2H	32296183
Intra	CD53	P19397	CLDN7	Homo sapiens	O95471	Y2H Prey Pooling	32296183
Intra	CD53	P19397	CLDN7	Homo sapiens	O95471	Y2H Array	32296183
Intra	CD53	P19397	SMIM3	Homo sapiens	Q9BZL3	Validated Y2H	32296183
Intra	CD53	P19397	BCL2L13	Homo sapiens	Q9BXK5	Y2H Array	32296183
Intra	CD53	P19397	BCL2L13	Homo sapiens	Q9BXK5	Y2H Prey Pooling	32296183
Intra	CD53	P19397	BCL2L13	Homo sapiens	Q9BXK5	Validated Y2H	32296183
Intra	CD53	P19397	IFITM3	Homo sapiens	Q01628	Validated Y2H	32296183
Intra	CD53	P19397	BTN2A2	Homo sapiens	Q8WVV5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

CD53 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81370	CD53 Antibody (YA1115)	IHC-P	Human
HY-P81370A	CD53 Antibody (YA1115)(PBS only)	IHC-P	Human
HY-P84157	CD53 Antibody (YA3854)	WB, IHC-P, FC, ELISA	Human
HY-P84157A	CD53 Antibody (YA3854)(PBS only)	WB, IHC-P, FC, ELISA	Human

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02254	CD53 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19881	Cd53 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26380	Cd53 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CD53	VGNC	VGNC:27039
Felis catus	CD53	VGNC	VGNC:60633
Canis familiaris	CD53	VGNC	VGNC:38964
Rattus norvegicus	CD53	RGD	RGD:2310
Macaca mulatta	CD53	VGNC	VGNC:70771
Mus musculus	CD53	MGD	MGI:88341
Others	CD53	NCBI