CD53 Antibody (YA3854)
(Synonyms: MOX44; TSPAN25)CD53 Antibody (YA3854) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to CD53.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
WB, IHC-P, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
CD53 Antibody (YA3854) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to CD53.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 35-55 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 24 kDa
Purified recombinant fragment of human CD53 (AA: extra mix) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD53 is a Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Plays a role in the activation of monocytes and B-cells. Acts as an essential regulator of B-cell development by promoting interleukin-7 receptor/IL7R signaling. Also promotes, in B-cells, the BCR signaling by recruiting PKC to the plasma membrane in order to phosphorylate its substrates. Plays an essential role in B- and T-cells homing to lymph nodes by stabilizing L-selectin/SELL cell surface expression. Also mediates metabolic and inflammatory functions in hepatocytes and adipose tissue by promoting TNF-alpha and LPS signaling independent of the immune compartment[1][2][3][4].
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Subcellular Localization
Cell membrane; Cell junction; Membrane; Multi-pass membrane protein; Synapse
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Expression
Tissue_specificity:B cells, monocytes, macrophages, neutrophils, single-positive (CD4 or CD8) thymocytes, and peripheral T cells -
Subunit
Interacts with SCIMP (PubMed:21930792). Interacts with CD45/PTPRC (PubMed:35767951). Interacts with IL7R (By similarity). Interacts with RBL2 and PPP2CA (By similarity)
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SwissProt ID
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Synonyms
MOX44; TSPAN25
Documentation
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