CNIH2 - cornichon family AMPA receptor auxiliary protein 2 Gene

Also Known as Cnil; CNIH-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 254263

About CNIH2

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:66,278,175-66,284,206 (from NCBI)

This gene has 6 transcripts (splice variants), 185 orthologues and 4 paralogues. Biased expression in brain (RPKM 22.4), adrenal (RPKM 2.7) and 1 other tissue.

Summary

The protein encoded by this gene is an auxiliary subunit of the ionotropic glutamate receptor of the AMPA subtype. AMPA receptors mediate fast synaptic neurotransmission in the central nervous system. This protein has been reported to interact with the Type I AMPA Receptor regulatory protein isoform gamma-8 to control assembly of hippocampal AMPA Receptor complexes, thereby modulating receptor gating and pharmacology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

CNIH2 Products (1)

mRNA Protein Name
NM_182553.3 NP_872359.1 protein cornichon homolog 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20805473 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of AMPA receptor activity IDA
IDA: Inferred from direct assay
20805473 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNIH2 Protein Structure

Cornichon

Cornichon: Cornichon protein (1 - 46)

Cornichon

Cornichon: Cornichon protein (56 - 152)

  • 0
  • 100
  • 160 a.a.
Protein Preferred Names Protein Names

protein cornichon homolog 2

  • cornichon homolog 2

CNIH2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CNIH2 Q6PI25 HIBADH Homo sapiens P31937
Y2H Array
32296183
Intra
CNIH2 Q6PI25 HIBADH Homo sapiens P31937
Y2H Prey Pooling
32296183
Intra
CNIH2 Q6PI25 TMPRSS2 Homo sapiens O15393-2
Y2H Array
32296183
Intra
CNIH2 Q6PI25 TMPRSS2 Homo sapiens O15393-2
Y2H Prey Pooling
32296183
Intra
CNIH2 Q6PI25 GORAB Homo sapiens Q5T7V8
Y2H Array
32296183
Intra
CNIH2 Q6PI25 GORAB Homo sapiens Q5T7V8
Y2H Prey Pooling
32296183
Intra
CNIH2 Q6PI25 CD53 Homo sapiens P19397
Y2H Prey Pooling
32296183
Intra
CNIH2 Q6PI25 CD53 Homo sapiens P19397
Y2H Array
32296183
Intra
CNIH2 Q6PI25 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
CNIH2 Q6PI25 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
CNIH2 Q6PI25 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra
CNIH2 Q6PI25 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra
CNIH2 Q6PI25 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02885 CNIH2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20890 Cnih2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27407 Cnih2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CNIH2 RGD RGD:1304930
Canis familiaris CNIH2 VGNC VGNC:39400
Felis catus CNIH2 VGNC VGNC:61016
Macaca mulatta CNIH2 VGNC VGNC:71366
Mus musculus CNIH2 MGD MGI:1277225
Bos taurus CNIH2 VGNC VGNC:106695
Others CNIH2 NCBI