CYBC1 - cytochrome b-245 chaperone 1 Gene

Also Known as CGD5; Eros; C17orf62

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79415

About CYBC1

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:82,442,586-82,450,752 (from NCBI)

This gene has 51 transcripts (splice variants), 193 orthologues and is associated with 2 phenotypes. Ubiquitous expression in spleen (RPKM 26.0), lymph node (RPKM 25.5) and 25 other tissues.

Summary

Involved in innate immune response and respiratory burst after phagocytosis. Located in endoplasmic reticulum. Implicated in chronic granulomatous disease. [provided by Alliance of Genome Resources, Apr 2022]

CYBC1 Products (7)

mRNA Protein Name
NM_001033046.4 NP_001028218.1 cytochrome b-245 chaperone 1 isoform a
NM_001100407.3 NP_001093877.1 cytochrome b-245 chaperone 1 isoform a
NM_001100408.3 NP_001093878.1 cytochrome b-245 chaperone 1 isoform b
NM_001193653.2 NP_001180582.1 cytochrome b-245 chaperone 1 isoform a
NM_001193654.2 NP_001180583.1 cytochrome b-245 chaperone 1 isoform a
NM_001193655.2 NP_001180584.1 cytochrome b-245 chaperone 1 isoform a
NM_001193657.2 NP_001180586.1 cytochrome b-245 chaperone 1 isoform a

CYBC1 Protein Structure

DUF4564

DUF4564: Domain of unknown function (DUF4564) (1 - 183)

  • 0
  • 100
  • 187 a.a.
Protein Preferred Names Protein Names

cytochrome b-245 chaperone 1

  • essential for reactive oxygen species protein

CYBC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CYBC1 Q9BQA9 SPN Homo sapiens P16150
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 SPN Homo sapiens P16150
Y2H Prey Pooling
32296183
Intra
CYBC1 Q9BQA9 NINJ2 Homo sapiens Q9NZG7
Validated Y2H
32296183
Intra
CYBC1 Q9BQA9 LXN Homo sapiens Q9BS40
Validated Y2H
32296183
Intra
CYBC1 Q9BQA9 CISD2 Homo sapiens Q8N5K1
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 CISD2 Homo sapiens Q8N5K1
Y2H Prey Pooling
32296183
Intra
CYBC1 Q9BQA9 HSD17B11 Homo sapiens Q8NBQ5
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 HSD17B11 Homo sapiens Q8NBQ5
Y2H Prey Pooling
32296183
Intra
CYBC1 Q9BQA9 P2RX1 Homo sapiens P51575
Y2H Prey Pooling
32296183
Intra
CYBC1 Q9BQA9 P2RX1 Homo sapiens P51575
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 TMEM80 Homo sapiens Q96HE8
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 TMEM80 Homo sapiens Q96HE8
Y2H Prey Pooling
32296183
Intra
CYBC1 Q9BQA9 GPR151 Homo sapiens Q8TDV0
Y2H Prey Pooling
32296183
Intra
CYBC1 Q9BQA9 GPR151 Homo sapiens Q8TDV0
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 MFF Homo sapiens Q9GZY8-5
Y2H Prey Pooling
32296183
Intra
CYBC1 Q9BQA9 MFF Homo sapiens Q9GZY8-5
Validated Y2H
32296183
Intra
CYBC1 Q9BQA9 MFF Homo sapiens Q9GZY8-5
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 STX2 Homo sapiens P32856-2
Y2H Prey Pooling
32296183
Intra
CYBC1 Q9BQA9 STX2 Homo sapiens P32856-2
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 AIG1 Homo sapiens Q9NVV5-2
Validated Y2H
32296183
Intra
CYBC1 Q9BQA9 AHNAK2 Homo sapiens Q8IVF2-3
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 AHNAK2 Homo sapiens Q8IVF2-3
Y2H Prey Pooling
32296183
Intra
CYBC1 Q9BQA9 TMPRSS2 Homo sapiens O15393-2
Y2H Prey Pooling
32296183
Intra
CYBC1 Q9BQA9 TMPRSS2 Homo sapiens O15393-2
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 APCDD1L Homo sapiens Q8NCL9
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 APCDD1L Homo sapiens Q8NCL9
Y2H Prey Pooling
32296183
Intra
CYBC1 Q9BQA9 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
CYBC1 Q9BQA9 NOX3 Homo sapiens Q9HBY0
Y2H Prey Pooling
32296183
Intra
CYBC1 Q9BQA9 NOX3 Homo sapiens Q9HBY0
Validated Y2H
32296183
Intra
CYBC1 Q9BQA9 NOX3 Homo sapiens Q9HBY0
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
CYBC1 Q9BQA9 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra
CYBC1 Q9BQA9 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra
CYBC1 Q9BQA9 SLC35C2 Homo sapiens Q9NQQ7-3
Validated Y2H
32296183
Intra
CYBC1 Q9BQA9 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra
CYBC1 Q9BQA9 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra
CYBC1 Q9BQA9 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 SHISA4 Homo sapiens Q96DD7
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 SHISA4 Homo sapiens Q96DD7
Y2H Prey Pooling
32296183
Intra
CYBC1 Q9BQA9 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra
CYBC1 Q9BQA9 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
CYBC1 Q9BQA9 AQP8 Homo sapiens O94778
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 AQP8 Homo sapiens O94778
Y2H Prey Pooling
32296183
Intra
CYBC1 Q9BQA9 TSPAN12 Homo sapiens O95859
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 TSPAN12 Homo sapiens O95859
Y2H Prey Pooling
32296183
Intra
CYBC1 Q9BQA9 MFSD14B Homo sapiens Q5SR56
Y2H Prey Pooling
32296183
Intra
CYBC1 Q9BQA9 MFSD14B Homo sapiens Q5SR56
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 MTIF3 Homo sapiens Q9H2K0
Y2H Prey Pooling
32296183
Intra
CYBC1 Q9BQA9 MTIF3 Homo sapiens Q9H2K0
Validated Y2H
32296183
Intra
CYBC1 Q9BQA9 MTIF3 Homo sapiens Q9H2K0
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 APOL2 Homo sapiens Q9BQE5
Validated Y2H
32296183
Intra
CYBC1 Q9BQA9 PEX12 Homo sapiens O00623
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 PEX12 Homo sapiens O00623
Y2H Prey Pooling
32296183
Intra
CYBC1 Q9BQA9 CLN6 Homo sapiens Q9NWW5
Validated Y2H
32296183
Intra
CYBC1 Q9BQA9 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
CYBC1 Q9BQA9 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
CYBC1 Q9BQA9 TM4SF19 Homo sapiens Q96DZ7
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 TM4SF19 Homo sapiens Q96DZ7
Y2H Prey Pooling
32296183
Intra
CYBC1 Q9BQA9 PDZK1IP1 Homo sapiens Q13113
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 PDZK1IP1 Homo sapiens Q13113
Y2H Prey Pooling
32296183
Intra
CYBC1 Q9BQA9 COQ9 Homo sapiens O75208
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 COQ9 Homo sapiens O75208
Y2H Prey Pooling
32296183
Intra
CYBC1 Q9BQA9 MGST3 Homo sapiens O14880
Y2H Prey Pooling
32296183
Intra
CYBC1 Q9BQA9 MGST3 Homo sapiens O14880
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 CLDN7 Homo sapiens O95471
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 KASH5 Homo sapiens Q8N6L0
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 KASH5 Homo sapiens Q8N6L0
Y2H Prey Pooling
25416956
Intra
CYBC1 Q9BQA9 KASH5 Homo sapiens Q8N6L0
Y2H Prey Pooling
32296183
Intra
CYBC1 Q9BQA9 KASH5 Homo sapiens Q8N6L0
Validated Y2H
25416956
Intra
CYBC1 Q9BQA9 KASH5 Homo sapiens Q8N6L0
Y2H Array
25416956
Intra
CYBC1 Q9BQA9 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
CYBC1 Q9BQA9 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
CYBC1 Q9BQA9 INSIG2 Homo sapiens Q9Y5U4
Validated Y2H
32296183
Intra
CYBC1 Q9BQA9 KIR2DL3 Homo sapiens P43628
Y2H Array
32296183
Intra
CYBC1 Q9BQA9 KIR2DL3 Homo sapiens P43628
Y2H Prey Pooling
32296183
Intra
CYBC1 Q9BQA9 ETS1 Homo sapiens P14921
TAP
20195357
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Granulomatous Disease, Chronic, Autosomal Recessive, 5

  • CGD5

  • Granulomatous Disease, Chronic, Due To Cybc1 Deficiency

  • Chronic Granulomatous Disease 5, Autosomal Recessive
Chronic Granulomatous Disease

  • Cgd

  • Granulomatous Disease, Chronic

  • Autosomal Recessive Chronic Granulomatous Disease

  • X-Linked Chronic Granulomatous Disease

  • Bridges-Good Syndrome

  • Congenital Dysphagocytosis

  • Quie Syndrome

  • Chronic Septic Granulomatosis

  • Chronic Granulomatous Disorder

  • Granulomatous Disease Chronic

  • Granulomatous Disease, Chronic, X-Linked
Hyperalphalipoproteinemia 1

  • Hyperalphalipoproteinemia

  • HALP1

  • Cetp Deficiency

  • Cholesterol-Ester Transfer Protein Deficiency

  • Familial Hyperalphalipoproteinemia

  • Cholesteryl Ester Transfer Protein Deficiency

  • Cept Deficiency

  • Cholesterol Ester Transfer Protein Deficiency
Lymphadenitis

  • Acute Lymphadenitis

  • Chronic Lymphadenitis

  • Adenitis

  • Chronic Adenitis

  • Acute Adenitis

  • Inflammation Of Lymph Node

  • Adenitis Nos

  • Inflammation Of Gland

  • Lymphatic Gland Inflammation

  • Lymph Gland Inflammation

  • Polyadenitis

  • Chronic Adenitis Of Any Lymph Node Except Mesenteric

  • Chronic Lymphadenitis Except Mesenteric

  • Chronic Non-Specific Lymphadenitis
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03426 CYBC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CYBC1 RGD RGD:1562022
Macaca mulatta CYBC1 VGNC VGNC:71601
Felis catus CYBC1 VGNC VGNC:98901
Canis familiaris CYBC1 VGNC VGNC:52590
Mus musculus CYBC1 MGD MGI:2384959
Bos taurus CYBC1 VGNC VGNC:52655
Others CYBC1 NCBI