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TM4SF19 - transmembrane 4 L six family member 19 Gene

Also Known as OCTM4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 116211

About TM4SF19

This gene has 4 transcripts (splice variants), 179 orthologues and 5 paralogues. Biased expression in testis (RPKM 3.1), esophagus (RPKM 0.9) and 10 other tissues.

Summary

The protein encoded by this gene is a member of the four-transmembrane L6 superfamily. Members of this family function in various cellular processes including cell proliferation, motility, and adhesion via their interactions with integrins. In human brain tissue, this gene is expressed at high levels in the parietal lobe, occipital lobe, hippocampus, pons, white matter, corpus callosum, and cerebellum. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]

TM4SF19 Products (3)

mRNA	Protein	Name
NM_001204897.2	NP_001191826.1	transmembrane 4 L6 family member 19 isoform 2
NM_001204898.2	NP_001191827.1	transmembrane 4 L6 family member 19 isoform 3
NM_138461.4	NP_612470.2	transmembrane 4 L6 family member 19 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	38016540	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TM4SF19 Protein Structure

L6_membrane

0
100
209 a.a.

Protein Preferred Names	Protein Names
transmembrane 4 L6 family member 19	osteoclast maturation-associated gene 4 protein

TM4SF19 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TM4SF19	Q96DZ7	TMEM237	Homo sapiens	Q96Q45-2	Validated Y2H	32296183
Intra	TM4SF19	Q96DZ7	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	TM4SF19	Q96DZ7	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	TM4SF19	Q96DZ7	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Array	32296183
Intra	TM4SF19	Q96DZ7	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Prey Pooling	32296183
Intra	TM4SF19	Q96DZ7	C4orf3	Homo sapiens	Q8WVX3-2	Y2H Prey Pooling	32296183
Intra	TM4SF19	Q96DZ7	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	TM4SF19	Q96DZ7	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	TM4SF19	Q96DZ7	TMEM167B	Homo sapiens	Q9NRX6	Validated Y2H	32296183
Intra	TM4SF19	Q96DZ7	TMEM167B	Homo sapiens	Q9NRX6	Y2H Array	32296183
Intra	TM4SF19	Q96DZ7	TMEM167B	Homo sapiens	Q9NRX6	Y2H Prey Pooling	32296183
Intra	TM4SF19	Q96DZ7	GET1	Homo sapiens	O00258	Y2H Prey Pooling	32296183
Intra	TM4SF19	Q96DZ7	GET1	Homo sapiens	O00258	Y2H Array	32296183
Intra	TM4SF19	Q96DZ7	CYBC1	Homo sapiens	Q9BQA9	Validated Y2H	32296183
Intra	TM4SF19	Q96DZ7	ATP6V0B	Homo sapiens	Q99437	Validated Y2H	32296183
Intra	TM4SF19	Q96DZ7	GIMAP5	Homo sapiens	Q96F15	Validated Y2H	32296183
Intra	TM4SF19	Q96DZ7	ERG28	Homo sapiens	Q9UKR5	Validated Y2H	32296183
Intra	TM4SF19	Q96DZ7	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	TM4SF19	Q96DZ7	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	TM4SF19	Q96DZ7	CCDC167	Homo sapiens	Q9P0B6	Validated Y2H	32296183
Intra	TM4SF19	Q96DZ7	UBE2J1	Homo sapiens	Q9Y385	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Immunodeficiency 46	Tfrc-Related Combined Immunodeficiency IMD46 Cid Due To Tfrc Deficiency Combined Immunodeficiency Due To Tfrc Deficiency
Chromosome 3q29 Deletion Syndrome	Chromosome 3q29 Microdeletion Syndrome 3q29 Microdeletion Syndrome 3q Subtelomere Deletion Syndrome 3q29 Recurrent Deletion 3qter Deletion 3q29 Deletion Syndrome Monosomy 3q29 Microdeletion 3q29 Syndrome Del(3)(Q29) Monosomy 3qter 3q29 Deletion Del3q29

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14607	TM4SF19 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TM4SF19	RGD	RGD:1560486
Mus musculus	TM4SF19	MGD	MGI:3645933
Others	TM4SF19	NCBI