CLDN7 - claudin 7 Gene

Also Known as CLDN-7; CEPTRL2; CPETRL2; Hs.84359; claudin-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1366

About CLDN7

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,259,903-7,263,213 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 165 orthologues and 22 paralogues. Biased expression in colon (RPKM 107.5), small intestine (RPKM 93.5) and 12 other tissues.

Summary

This gene encodes a member of the Claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast Cancer, ovarian Cancer, hepatocellular carcinomas, urinary tumors, prostate Cancer, lung Cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010]

CLDN7 Products (3)

mRNA	Protein	Name
NM_001185022.2	NP_001171951.1	claudin-7 isoform 1 precursor
NM_001185023.2	NP_001171952.1	claudin-7 isoform 2 precursor
NM_001307.6	NP_001298.3	claudin-7 isoform 1 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16054130	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	12673207	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLDN7 Protein Structure

PMP22_Claudin

0
100
200
211 a.a.

Protein Preferred Names	Protein Names
claudin-7	clostridium perfringens enterotoxin receptor-like 2

CLDN7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CLDN7	O95471	UPK2	Homo sapiens	O00526	Y2H Prey Pooling	32296183
Intra	CLDN7	O95471	EDDM3B	Homo sapiens	P56851	Validated Y2H	32296183
Intra	CLDN7	O95471	TTMP	Homo sapiens	Q5BVD1	Validated Y2H	32296183
Intra	CLDN7	O95471	RTP2	Homo sapiens	Q5QGT7	Validated Y2H	32296183
Intra	CLDN7	O95471	LSMEM2	Homo sapiens	Q8N112	Validated Y2H	32296183
Intra	CLDN7	O95471	JAGN1	Homo sapiens	Q8N5M9	Validated Y2H	32296183
Intra	CLDN7	O95471	CYB561A3	Homo sapiens	Q8NBI2	Validated Y2H	32296183
Intra	CLDN7	O95471	SLC38A7	Homo sapiens	Q9NVC3	Validated Y2H	32296183
Intra	CLDN7	O95471	RPRM	Homo sapiens	Q9NS64	Validated Y2H	32296183
Intra	CLDN7	O95471	TMEM128	Homo sapiens	Q5BJH2-2	Validated Y2H	32296183
Intra	CLDN7	O95471	ERMP1	Homo sapiens	Q7Z2K6	Validated Y2H	32296183
Intra	CLDN7	O95471	CMTM5	Homo sapiens	Q96DZ9-2	Validated Y2H	32296183
Intra	CLDN7	O95471	ASGR1	Homo sapiens	P07306	Validated Y2H	32296183
Intra	CLDN7	O95471	AIG1	Homo sapiens	Q9NVV5-2	Validated Y2H	32296183
Intra	CLDN7	O95471	LPAR3	Homo sapiens	Q9UBY5	Validated Y2H	32296183
Intra	CLDN7	O95471	TSPAN33	Homo sapiens	Q86UF1	Validated Y2H	32296183
Intra	CLDN7	O95471	SCARF1	Homo sapiens	Q14162	Validated Y2H	32296183
Intra	CLDN7	O95471	MS4A13	Homo sapiens	Q5J8X5	Validated Y2H	32296183
Intra	CLDN7	O95471	PGAP2	Homo sapiens	Q9UHJ9-5	Validated Y2H	32296183
Intra	CLDN7	O95471	ANKRD46	Homo sapiens	Q86W74-2	Validated Y2H	32296183
Intra	CLDN7	O95471	TMEM97	Homo sapiens	Q5BJF2	Validated Y2H	32296183
Intra	CLDN7	O95471	FAXDC2	Homo sapiens	Q96IV6	Validated Y2H	32296183
Intra	CLDN7	O95471	VSTM1	Homo sapiens	Q6UX27-3	Validated Y2H	32296183
Intra	CLDN7	O95471	COL4A5	Homo sapiens	P29400-2	Validated Y2H	32296183
Intra	CLDN7	O95471	NDUFB11	Homo sapiens	Q9NX14	Validated Y2H	32296183
Intra	CLDN7	O95471	TMEM44	Homo sapiens	Q2T9K0-2	Validated Y2H	32296183
Intra	CLDN7	O95471	CYBC1	Homo sapiens	Q9BQA9	Validated Y2H	32296183
Intra	CLDN7	O95471	CYBC1	Homo sapiens	Q9BQA9	Y2H Prey Pooling	32296183
Intra	CLDN7	O95471	OLFM4	Homo sapiens	Q6UX06	Validated Y2H	32296183
Intra	CLDN7	O95471	UBIAD1	Homo sapiens	Q9Y5Z9	Validated Y2H	32296183
Intra	CLDN7	O95471	TMEM140	Homo sapiens	Q9NV12	Validated Y2H	32296183
Intra	CLDN7	O95471	TMEM60	Homo sapiens	Q9H2L4	Validated Y2H	32296183
Intra	CLDN7	O95471	CD72	Homo sapiens	P21854	Validated Y2H	32296183
Intra	CLDN7	O95471	TMEM147	Homo sapiens	Q9BVK8	Validated Y2H	32296183
Intra	CLDN7	O95471	TNF	Homo sapiens	P01375	Validated Y2H	32296183
Intra	CLDN7	O95471	EMP3	Homo sapiens	P54852	Validated Y2H	32296183
Intra	CLDN7	O95471	CXCL9	Homo sapiens	Q07325	Validated Y2H	32296183
Intra	CLDN7	O95471	NKG7	Homo sapiens	Q16617	Validated Y2H	32296183
Intra	CLDN7	O95471	MFSD5	Homo sapiens	Q6N075	Validated Y2H	32296183
Intra	CLDN7	O95471	MAL	Homo sapiens	P21145	Validated Y2H	32296183
Intra	CLDN7	O95471	UNC93B1	Homo sapiens	Q9H1C4	Validated Y2H	32296183
Intra	CLDN7	O95471	SCAMP4	Homo sapiens	Q969E2	Validated Y2H	32296183
Intra	CLDN7	O95471	CLN6	Homo sapiens	Q9NWW5	Validated Y2H	32296183
Intra	CLDN7	O95471	GIMAP5	Homo sapiens	Q96F15	Validated Y2H	32296183
Intra	CLDN7	O95471	CD53	Homo sapiens	P19397	Validated Y2H	32296183
Intra	CLDN7	O95471	PLN	Homo sapiens	P26678	Validated Y2H	32296183
Intra	CLDN7	O95471	PLN	Homo sapiens	P26678	Y2H Array	32296183
Intra	CLDN7	O95471	BCL2L2	Homo sapiens	Q92843	Validated Y2H	32296183
Intra	CLDN7	O95471	ERG28	Homo sapiens	Q9UKR5	Validated Y2H	32296183
Intra	CLDN7	O95471	SYNE4	Homo sapiens	Q8N205	Validated Y2H	25416956
Intra	CLDN7	O95471	SYNE4	Homo sapiens	Q8N205	Y2H Prey Pooling	25416956
Intra	CLDN7	O95471	FXYD6	Homo sapiens	Q9H0Q3	Validated Y2H	32296183
Intra	CLDN7	O95471	APOD	Homo sapiens	P05090	Validated Y2H	32296183
Intra	CLDN7	O95471	IGFBP5	Homo sapiens	P24593	Validated Y2H	32296183
Intra	CLDN7	O95471	VAMP3	Homo sapiens	Q15836	Validated Y2H	32296183
Intra	CLDN7	O95471	TMEM11	Homo sapiens	P17152	Validated Y2H	32296183
Intra	CLDN7	O95471	MALL	Homo sapiens	Q13021	Validated Y2H	32296183
Intra	CLDN7	O95471	TMEM100	Homo sapiens	Q9NV29	Validated Y2H	32296183
Intra	CLDN7	O95471	NIPAL4	Homo sapiens	Q0D2K0	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

CLDN7 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P85798	Claudin 7 Antibody (YA5490)	IHC-P, WB, ICC/IF, ELISA	Human
HY-P85908	Claudin 7 Antibody (YA5600)	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat
HY-P85996	Claudin 7 Antibody (YA5688)	IHC-P, ELISA	Human
HY-P86030	Claudin 7 Antibody (YA5722)	IHC-P, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Ductal Carcinoma In Situ	Noninfiltrating Intraductal Carcinoma
Oncocytoma	Oxyphilic Adenoma Follicular Adenoma, Oxyphilic Cell Adenoma, Oxyphilic Hurthle Cell Tumor Oncocytic Neoplasm
Diarrhea 5, With Tufting Enteropathy, Congenital	Congenital Diarrhea 5 With Tufting Enteropathy Congenital Tufting Enteropathy DIAR5 Cte Intestinal Epithelial Cell Dysplasia Tufting Enteropathy Ied Intestinal Epithelial Dysplasia Enteropathy, Congenital Tufting Congenital Diarrhoea 5 With Tufting Enteropathy Congenital Familial Intractable Diarrhea With Epithelial Or Epithelium Abnormalities Congenital Familial Intractable Diarrhoea With Epithelial Or Epithelium Abnormalities Congenital Enteropathy Congenital Familial Intractable Diarrhea With Enterocytes Assembly Abnormalities Non-Syndromic Congenital Tufting Enteropathy Diarrhea, Type 5, With Tufting Enteropathy, Congenital Intestinal Intraepithelial Neoplasia
Prostate Transitional Cell Carcinoma	Transitional Cell Carcinoma Of Prostate Primary Prostate Urothelial Carcinoma
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Gastric Adenocarcinoma	Adenocarcinoma Of Stomach Stomach Adenocarcinoma Adenocarcinoma Gastric Intestinal Type Adenocarcinoma Of Unspecified Site Diffuse Type Adenocarcinoma Of Unspecified Site
Renal Oncocytoma	Oncocytoma, Renal Oncocytoma Of Kidney Renal Epithelial Oncocytic Tumor Oncocytoma Kidney Oncocytoma Renal Kidney Oncocytoma
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Congenital Diarrhea
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Astigmatism
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Chromophobe Renal Cell Carcinoma	Chromophobe Adenocarcinoma Chromophobe Carcinoma Of Kidney Kidney Chromophobe Renal Cell Carcinoma, Chromophobe Cell Crcc Chrcc Chromophobe Renal Cell Adenocarcinoma Chromophobe Renal Carcinoma Chromophobe Carcinoma
Squamous Cell Carcinoma, Head And Neck	Squamous Cell Carcinoma Of The Head And Neck HNSCC Head And Neck Squamous Cell Carcinoma Squamous Cell Carcinoma Of Lip Squamous Cell Carcinoma, Head And Neck, Somatic Carcinoma Of The Head And Neck Squamous Cell Carcinomas Of Head And Neck Scchn Squamous Cell Carcinoma Of The Hypopharynx Squamous Cell Carcinoma Of The Oropharynx Squamous Cell Carcinoma Of Salivary Glands Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses Squamous Cell Carcinoma Of The Oral Cavity Squamous Cell Carcinoma Of The Lip Carcinoma, Squamous Cell Of Head And Neck Lip Squamous Cell Carcinoma Carcinoma, Squamous Cell, Head And Neck Salivary Gland Squamous Cell Carcinoma Cancer Of Head And Neck Squamous Cell Carcinoma Of Oropharynx Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02775	CLDN7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21533	Cldn7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28051	Cldn7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CLDN7	MGD	MGI:1859285
Bos taurus	CLDN7	VGNC	VGNC:55796
Felis catus	CLDN7	VGNC	VGNC:98884
Macaca mulatta	CLDN7	VGNC	VGNC:97752
Canis familiaris	CLDN7	VGNC	VGNC:53320
Rattus norvegicus	CLDN7	RGD	RGD:68432
Others	CLDN7	NCBI