Search Result

No matches for "

64184

" within the MedChemExpress (MCE) catalog. Here are the results you might be looking for.

By Targets:	Apoptosis (1) Caspase (1) COX (3) Isotope-Labeled Compounds (1) MicroRNA (12) NEKs (1) NF-κB (1) NOD-like Receptor (NLR) (1) Pyroptosis (1) Reference Standards (1)
By Research Areas:	Cancer (16) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (4) Neurological Disease (1)
Oligonucleotides:	miRNA mimics (3) miRNA agomirs (3) miRNA antagomirs (3) MicroRNAs (12) miRNA inhibitors (3)

Inhibitors & Agonists

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-159520

Ofirnoflastum Ofirnoflast; HT-6184	NEKs NOD-like Receptor (NLR) Caspase Apoptosis Pyroptosis NF-κB	Cardiovascular Disease Inflammation/Immunology Cancer
Ofirnoflastum (Ofirnoflast) is an orally active first-in-class allosteric NEK7 inhibitor with an IC₅₀ of 46 nM. Ofirnoflastum binds an allosteric site adjacent to NEK7’s ATP-binding pocket, induces conformational shifts, disrupts NEK7-NLRP3 binding, blocks NLRP3 inflammasome assembly, spares NEK7’s physiological functions, and suppresses caspase-1, caspase-8, NF-κB, and TNF activity. Ofirnoflastum reduces pro-inflammatory cytokine production, suppresses ASC specks, IL-1β release, pyroptotic cell death, and leukemic burden, induces apoptosis and erythroid differentiation, restores hematopoiesis, and improves outcomes in colitis models. Ofirnoflastum can be used for the research of myelodysplastic syndromes, chronic myelomonocytic leukemia, and acute myeloid leukemia .

HY-B0335

Tolfenamic Acid 2 Publications Verification GEA 6414	COX	Infection Neurological Disease Inflammation/Immunology Cancer
Tolfenamic Acid (GEA 6414) is a CNS-penetrant non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC₅₀ of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.

HY-B0335R

Tolfenamic Acid (Standard) GEA 6414 (Standard)	Reference Standards COX	Inflammation/Immunology Cancer
Tolfenamic Acid (Standard) is the analytical standard of Tolfenamic Acid. This product is intended for research and analytical applications. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC₅₀ of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.

HY-B0335S1

Tolfenamic acid-13C6 GEA 6414-¹³C₆	Isotope-Labeled Compounds COX	Inflammation/Immunology Cancer
Tolfenamic acid- ¹³C₆ is the ¹³C₆ labeled Tolfenamic acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.

HY-R03421

*mmu-miR-6414* mimic**	MicroRNA	Cancer
mmu-miR-6414 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-miR-6414 mimic mmu-miR-6414 mimic

HY-RI03421

*mmu-miR-6414* inhibitor**	MicroRNA	Cancer
mmu-miR-6414 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-miR-6414 inhibitor mmu-miR-6414 inhibitor

HY-RI03426

*mmu-miR-6418-3p inhibitor*	MicroRNA	Cancer
mmu-miR-6418-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-miR-6418-3p inhibitor mmu-miR-6418-3p inhibitor

HY-RI03427A

*mmu-miR-6418-5p antagomir*	MicroRNA	Cancer
mmu-miR-6418-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-6418-5p antagomir mmu-miR-6418-5p antagomir

HY-RI03427

*mmu-miR-6418-5p inhibitor*	MicroRNA	Cancer
mmu-miR-6418-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-miR-6418-5p inhibitor mmu-miR-6418-5p inhibitor

HY-R03427A

*mmu-miR-6418-5p agomir*	MicroRNA	Cancer
mmu-miR-6418-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-6418-5p agomir mmu-miR-6418-5p agomir

HY-RI03426A

*mmu-miR-6418-3p antagomir*	MicroRNA	Cancer
mmu-miR-6418-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-6418-3p antagomir mmu-miR-6418-3p antagomir

HY-R03426

*mmu-miR-6418-3p mimic*	MicroRNA	Cancer
mmu-miR-6418-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-miR-6418-3p mimic mmu-miR-6418-3p mimic

HY-RI03421A

*mmu-miR-6414* antagomir**	MicroRNA	Cancer
mmu-miR-6414 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-6414 antagomir mmu-miR-6414 antagomir

HY-R03421A

*mmu-miR-6414* agomir**	MicroRNA	Cancer
mmu-miR-6414 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-6414 agomir mmu-miR-6414 agomir

HY-R03426A

*mmu-miR-6418-3p agomir*	MicroRNA	Cancer
mmu-miR-6418-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-6418-3p agomir mmu-miR-6418-3p agomir

HY-R03427

*mmu-miR-6418-5p mimic*	MicroRNA	Cancer
mmu-miR-6418-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-miR-6418-5p mimic mmu-miR-6418-5p mimic

Cat. No.	Product Name	Chemical Structure

HY-B0335S1

Tolfenamic acid-13C6
Tolfenamic acid- ¹³C₆ is the ¹³C₆ labeled Tolfenamic acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.

Host:	Mouse (5) Rabbit (2)
Reactivity:	Human (7) Rat (2) Mouse (2)
Application:	IHC-P (6) ICC/IF (3) IF-Tissue (3) IP (1) IHC-F (3) WB (7) FC (2) ELISA (3)
Isotype:	IgG (5) IgG2a (2)
Conjugation:	Non-conjugated (8)
Clonality:	Monoclonal (5) Recombinant (1)
Modification:	Unmodified (5)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84487

	Dynamin I Antibody (YA4184) DNM; DNM1	WB, IHC-P, ELISA	Human
	Dynamin I Antibody (YA4184) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Dynamin I.

HY-P84487A

	Dynamin I Antibody (YA4184)(PBS only) DNM; DNM1	WB, IHC-P, ELISA	Human
	Dynamin I Antibody (YA4184) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Dynamin I.

HY-P86726

	Vimentin Antibody (YA6418) FLJ36605; OTTHUMP00000019224; VIM; VIME_HUMAN; Vimentin.	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue, FC	Human
	Vimentin Antibody (YA6418) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to Vimentin.

HY-P86726A

	Vimentin Antibody (YA6418)(PBS only) FLJ36605; OTTHUMP00000019224; VIM; VIME_HUMAN; Vimentin.
	Vimentin Antibody (YA6418) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to Vimentin.

HY-P86492

	NF-κB p65 Antibody (YA6184) RELA; NFKB3; Transcription factor p65; Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	NF-κB p65 Antibody (YA6184) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NF-κB p65.

HY-P86722

	Cytokeratin 17 Antibody (YA6414) 39.1; CK 17; Cytokeratin 17; Cytokeratin17; K17; Keratin 17; Keratin type I cytoskeletal 17; Keratin17; KRT 17; KRT17; KRT17 protein; PC; PC2; PCHC1; K1C17_HUMAN.	WB, IHC-P, IHC-F, IF-Tissue	Human
	Cytokeratin 17 Antibody (YA6414) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to Cytokeratin 17.

HY-P86722A

	Cytokeratin 17 Antibody (YA6414)(PBS only) 39.1; CK 17; Cytokeratin 17; Cytokeratin17; K17; Keratin 17; Keratin type I cytoskeletal 17; Keratin17; KRT 17; KRT17; KRT17 protein; PC; PC2; PCHC1; K1C17_HUMAN.	WB, IHC-P, IHC-F, IF-Tissue	Human
	Cytokeratin 17 Antibody (YA6414) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to Cytokeratin 17.

HY-P86791

	BRCC45/BRE Antibody (YA6484) 6030405P19Rik antibody; AI429776 antibody; B830038C02Rik antibody; Brain and reproductive organ expressed (TNFRSF1A modulator) antibody; brain and reproductive organ expressed protein antibody; Brain and reproductive organ-expressed protein antibody; BRCA1 A complex subunit BRE antibody; BRCA1-A complex subunit BRE antibody; BRCA1/BRCA2 containing complex subunit 4 antibody; BRCA1/BRCA2 containing complex subunit 45 antibody; 6030405P19Rik antibody; AI429776 antibody; B830038C02Rik antibody; Brain and reproductive organ expressed (TNFRSF1A modulator) antibody; brain and reproductive organ expressed protein antibody; Brain and reproductive organ-expressed protein antibody; BRCA1 A complex subunit BRE antibody; BRCA1-A complex subunit BRE antibody; BRCA1/BRCA2 containing complex subunit 4 antibody; BRCA1/BRCA2 containing complex subunit 45 antibody; BRCA1/BRCA2-containing complex subunit 45 antibody; BRCC4 antibody; BRCC45 antibody; bre antibody; BRE_HUMAN antibody;	WB, ICC/IF, FC	Human, Mouse, Rat
	BRCC45/BRE Antibody (YA6484) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BRCC45/BRE.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-R03421

*mmu-miR-6414* mimic**		MicroRNAs miRNA mimics
mmu-miR-6414 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-RI03421

*mmu-miR-6414* inhibitor**		MicroRNAs miRNA inhibitors
mmu-miR-6414 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-RI03426

*mmu-miR-6418-3p inhibitor*		MicroRNAs miRNA inhibitors
mmu-miR-6418-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-RI03427A

*mmu-miR-6418-5p antagomir*		MicroRNAs miRNA antagomirs
mmu-miR-6418-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI03427

*mmu-miR-6418-5p inhibitor*		MicroRNAs miRNA inhibitors
mmu-miR-6418-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-R03427A

*mmu-miR-6418-5p agomir*		MicroRNAs miRNA agomirs
mmu-miR-6418-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI03426A

*mmu-miR-6418-3p antagomir*		MicroRNAs miRNA antagomirs
mmu-miR-6418-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R03426

*mmu-miR-6418-3p mimic*		MicroRNAs miRNA mimics
mmu-miR-6418-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-RI03421A

*mmu-miR-6414* antagomir**		MicroRNAs miRNA antagomirs
mmu-miR-6414 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R03421A

*mmu-miR-6414* agomir**		MicroRNAs miRNA agomirs
mmu-miR-6414 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R03426A

*mmu-miR-6418-3p agomir*		MicroRNAs miRNA agomirs
mmu-miR-6418-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R03427

*mmu-miR-6418-5p mimic*		MicroRNAs miRNA mimics
mmu-miR-6418-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

Inquiry Online

Submit your filled information, we will contact you soon.

Salutation:		* Country or Region:
* Applicant Name:		* Organization Name:
* Department:
* Email Address:		* Product Name:
Cat. No.:		* Requested quantity:
* Phone Number:
MCE Japan Authorized Agent:	ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Remarks:

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: