13710-19-5
13710-19-5
Chemical Structure
Tolfenamic Acid
Synonym(s): GEA 6414
- CAS No.: 13710-19-5
- Formula:C14H12ClNO2
- Molecular Weight:261.70
IUPAC Name: 2-((3-chloro-2-methylphenyl)amino)benzoic acid
InChIKey: YEZNLOUZAIOMLT-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC=CC=C1NC2=C(C)C(Cl)=CC=C2
Biological Activity: Tolfenamic Acid (GEA 6414) is a CNS-penetrant non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Tolfenamic Acid | 99.94% | Tolfenamic Acid (GEA 6414) is a CNS-penetrant non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1. | ||||||||||||||||||||
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Tolfenamic Acid (Standard) | 99.97% | Tolfenamic Acid (Standard) is the analytical standard of Tolfenamic Acid. This product is intended for research and analytical applications. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1. | ||||||||||||||||||||
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Tolfenamic acid-d4 | Tolfenamic acid-d4 is the deuterium labeled Tolfenamic Acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1. | |||||||||||||||||||||
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Tolfenamic acid-13C6 | 99.7% | Tolfenamic acid-13C6 is the 13C6 labeled Tolfenamic acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1. | ||||||||||||||||||||
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