N-(3-Methylphenyl)anthranilic acid (Synonyms: 3-MFA)

Cat. No.: HY-W414731 Purity: 99.82%: Data Sheet
COA

SDS
Handling Instructions
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N-(3-Methylphenyl)anthranilic acid is an aldo-keto reductase 1C3 (AKR1C3)and AKR1C2 inhibitor with IC₅₀ values of 0.24 μM and 0.38 μM, respectively. N-(3-Methylphenyl)anthranilic acid shows no inhibition of COX-1 or COX-2. N-(3-Methylphenyl)anthranilic acid can be used for the research of castration resistant prostate cancer.

For research use only. We do not sell to patients.

N-(3-Methylphenyl)anthranilic acid Chemical Structure

CAS No. : 16524-22-4

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Description

In Vitro

N-(3-Methylphenyl)anthranilic acid (compound 1h) inhibits AKR1C3 and AKR1C2 (IC₅₀ = 0.24 μM for AKR1C3; 0.38 μM for AKR1C2) and shows 2-fold selectivity for AKR1C3 over AKR1C2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

227.26

Formula

C₁₄H₁₃NO₂

CAS No.

16524-22-4

Appearance

Solid

Color

Yellow to brown

SMILES

O=C(O)C=1C=CC=CC1NC2=CC=CC(=C2)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 83.33 mg/mL (366.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.4002 mL	22.0012 mL	44.0025 mL
5 mM	0.8800 mL	4.4002 mL	8.8005 mL
10 mM	0.4400 mL	2.2001 mL	4.4002 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.82%

Select Batch:

Data Sheet (273 KB) SDS (598 KB)

COA (251 KB) HNMR (289 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Adeniji AO, et al. Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships. J Med Chem. 2012;55(5):2311-2323. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.4002 mL	22.0012 mL	44.0025 mL	110.0062 mL
	5 mM	0.8800 mL	4.4002 mL	8.8005 mL	22.0012 mL
	10 mM	0.4400 mL	2.2001 mL	4.4002 mL	11.0006 mL
	15 mM	0.2933 mL	1.4667 mL	2.9335 mL	7.3337 mL
	20 mM	0.2200 mL	1.1001 mL	2.2001 mL	5.5003 mL
	25 mM	0.1760 mL	0.8800 mL	1.7601 mL	4.4002 mL
	30 mM	0.1467 mL	0.7334 mL	1.4667 mL	3.6669 mL
	40 mM	0.1100 mL	0.5500 mL	1.1001 mL	2.7502 mL
	50 mM	0.0880 mL	0.4400 mL	0.8800 mL	2.2001 mL
	60 mM	0.0733 mL	0.3667 mL	0.7334 mL	1.8334 mL
	80 mM	0.0550 mL	0.2750 mL	0.5500 mL	1.3751 mL
	100 mM	0.0440 mL	0.2200 mL	0.4400 mL	1.1001 mL

N-(3-Methylphenyl)anthranilic acid Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-(3-Methylphenyl)anthranilic acid16524-22-43-MFAAldose ReductaseAKR1C1AKR1C2COX-1Aldo?keto reductase 1C3COX-2testosteronecancer cellsAKR1C3castration resistant prostate cancerInhibitorinhibitorinhibit

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N-(3-Methylphenyl)anthranilic acid (Synonyms: 3-MFA)

N-(3-Methylphenyl)anthranilic acid Related Antibodies

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