N-(3-Methylphenyl)anthranilic acid
Based on 1 Customer Validation
N-(3-Methylphenyl)anthranilic acid is an aldo-keto reductase 1C3 (AKR1C3)and AKR1C2 inhibitor with IC50 values of 0.24 μM and 0.38 μM, respectively. N-(3-Methylphenyl)anthranilic acid shows no inhibition of COX-1 or COX-2. N-(3-Methylphenyl)anthranilic acid can be used for the research of castration resistant prostate cancer.
For research use only. We do not sell to patients.
- Purity: 99.82%
- CAS No.: 16524-22-4
- Formula: C14H13NO2
- Molecular Weight:227.26
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
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Bioactive Compound Library
HY-L001
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Anti-Cancer Compound Library
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Anti-Prostate Cancer Compound Library
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Multi-Target Compound Library
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MCE Bioactive Compound Library
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High-Throughput Bioactive Compound Library
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Biological Activity
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AKR1C3 0.24 μM (IC50) |
AKR1C2 0.38 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
76 μM
Compound: 3-MFA
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Inhibition of human TRPM2 expressed in HEK293 cells assessed as inhibition of ADP-ribose-induced current by patch clamp electrophysiology
Inhibition of human TRPM2 expressed in HEK293 cells assessed as inhibition of ADP-ribose-induced current by patch clamp electrophysiology
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[PMID: 24304219] |
N-(3-Methylphenyl)anthranilic acid (compound 1h) inhibits AKR1C3 and AKR1C2 (IC50 = 0.24 μM for AKR1C3; 0.38 μM for AKR1C2) and shows 2-fold selectivity for AKR1C3 over AKR1C2[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 16524-22-4
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Appearance Solid
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Molecular Weight 227.26
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Formula C14H13NO2
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Color Yellow to brown
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SMILES
O=C(O)C=1C=CC=CC1NC2=CC=CC(=C2)C
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Synonyms
3-MFA
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 83.33 mg/mL (366.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (598 KB)
- English - EN (598 KB)
- Français - FR (598 KB)
- Deutsch - DE (598 KB)
- Norwegian - NO (598 KB)
- Español - ES (598 KB)
- Swedish - SV (598 KB)
- Italian - IT (598 KB)
- Korean - KR (598 KB)
- Portuguese - PT (598 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.4002 mL | 22.0012 mL | 44.0025 mL | 110.0062 mL |
| 5 mM | 0.8800 mL | 4.4002 mL | 8.8005 mL | 22.0012 mL | |
| 10 mM | 0.4400 mL | 2.2001 mL | 4.4002 mL | 11.0006 mL | |
| 15 mM | 0.2933 mL | 1.4667 mL | 2.9335 mL | 7.3337 mL | |
| 20 mM | 0.2200 mL | 1.1001 mL | 2.2001 mL | 5.5003 mL | |
| 25 mM | 0.1760 mL | 0.8800 mL | 1.7601 mL | 4.4002 mL | |
| 30 mM | 0.1467 mL | 0.7334 mL | 1.4667 mL | 3.6669 mL | |
| 40 mM | 0.1100 mL | 0.5500 mL | 1.1001 mL | 2.7502 mL | |
| 50 mM | 0.0880 mL | 0.4400 mL | 0.8800 mL | 2.2001 mL | |
| 60 mM | 0.0733 mL | 0.3667 mL | 0.7334 mL | 1.8334 mL | |
| 80 mM | 0.0550 mL | 0.2750 mL | 0.5500 mL | 1.3751 mL | |
| 100 mM | 0.0440 mL | 0.2200 mL | 0.4400 mL | 1.1001 mL |
N-(3-Methylphenyl)anthranilic acid Related Classifications
HY-W414731 Related Classifications
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