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  3. Mefenamic acid

Mefenamic acid 

Cat. No.: HY-B0574 Purity: 99.99%
Handling Instructions

Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively.

For research use only. We do not sell to patients.

Mefenamic acid Chemical Structure

Mefenamic acid Chemical Structure

CAS No. : 61-68-7

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1  mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
500 mg USD 55 In-stock
Estimated Time of Arrival: December 31
5 g USD 96 In-stock
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10 g USD 180 In-stock
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50 g   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively.

IC50 & Target[1]

hCOX-1

40 nM (IC50)

hCOX-2

3 μM (IC50)

In Vitro

Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively[1]. Mefenamic acid (0-100 μM) has cytotoxic effects on KB, Saos-2, and 1321N cells, however, U-87MG cells are resistant to Mefenamic acid[2].

Clinical Trial
Molecular Weight

241.29

Formula

C₁₅H₁₅NO₂

CAS No.

61-68-7

SMILES

O=C(O)C1=CC=CC=C1NC2=CC=CC(C)=C2C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (414.44 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1444 mL 20.7220 mL 41.4439 mL
5 mM 0.8289 mL 4.1444 mL 8.2888 mL
10 mM 0.4144 mL 2.0722 mL 4.1444 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (10.36 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (10.36 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Cell Assay
[2]

Powder forms of Mefenamic acid, indometacin, aspirin, and celecoxib are dissolved in 0.1% dimethyl sulfoxide (DMSO) to achieve a concentration of 100 μM of stock solution, which is sterilized by filtration through a 0.22-µm filter and then stored at 4°C. Different concentrations (100, 50, 25, 10, and 5 μM) of the drugs (Mefenamic acid, etc.) are prepared by serial dilutions with the FCS-free medium or the medium containing 10% FCS in sterile plastic centrifuge tubes[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

Mefenamic acidCOXCyclooxygenaseInhibitorinhibitorinhibit

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Product Name:
Mefenamic acid
Cat. No.:
HY-B0574
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