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Dichlorophenyl-ABA 

Cat. No.: HY-113950 Purity: >99.0%
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Dichlorophenyl-ABA is an inhibitor of transthyretin (TTR) amyloid fibril formation, inhibiting aggregate formation in more than 80% in TTR L55P-expressing cells.

For research use only. We do not sell to patients.

Dichlorophenyl-ABA Chemical Structure

Dichlorophenyl-ABA Chemical Structure

CAS No. : 18201-65-5

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Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Dichlorophenyl-ABA is an inhibitor of transthyretin (TTR) amyloid fibril formation, inhibiting aggregate formation in more than 80% in TTR L55P-expressing cells[1].

IC50 & Target

Transthyretin (TTR) amyloid fibril formation

In Vitro

Dichlorophenyl-ABA (DCPA) is able to prevent L55P aggregate formation in the conditioned medium. With regard to the ultrastructural analysis, Dichlorophenyl-ABA does not show an inhibitory effect as high as DFPB and benzoxazole, indicating that the Y78F mutant may not be as sensitive to this drug as TTR L55P and V30M are[1].
Dichlorophenyl-ABA is the best stabilizers of V30M tetramers in plasma from carriers of this mutant, and clearly inhibit aggregation in the cellular system. Therefore Dichlorophenyl-ABA is promising for the treatment of valine at position 30 (V30M)-associated familial amyloidotic polyneuropathy (FAP) but need to undergo further stages of drug development to overcome their toxicity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

282.12

Formula

C₁₃H₉Cl₂NO₂

CAS No.

18201-65-5

SMILES

O=C(O)C1=CC=CC=C1NC2=CC(Cl)=CC(Cl)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References

Purity: >99.0%

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Keywords:

Dichlorophenyl-ABAOthersTransthyretinamyloidfibrilformationaggregatestabilizationtoxicitypartiallyInhibitorinhibitorinhibit

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Dichlorophenyl-ABA
Cat. No.:
HY-113950
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