Dichlorophenyl-ABA
Based on 1 Customer Validation
Dichlorophenyl-ABA is an inhibitor of transthyretin (TTR) amyloid fibril formation, inhibiting aggregate formation in more than 80% in TTR L55P-expressing cells.
For research use only. We do not sell to patients.
- Purity: 99.79%
- CAS No.: 18201-65-5
- Formula: C13H9Cl2NO2
- Molecular Weight:282.12
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Transthyretin (TTR) amyloid fibril formation
Dichlorophenyl-ABA (DCPA) is able to prevent L55P aggregate formation in the conditioned medium. With regard to the ultrastructural analysis, Dichlorophenyl-ABA does not show an inhibitory effect as high as DFPB and benzoxazole, indicating that the Y78F mutant may not be as sensitive to this drug as TTR L55P and V30M are[1].
Dichlorophenyl-ABA is the best stabilizers of V30M tetramers in plasma from carriers of this mutant, and clearly inhibit aggregation in the cellular system. Therefore Dichlorophenyl-ABA is promising for the treatment of valine at position 30 (V30M)-associated familial amyloidotic polyneuropathy (FAP) but need to undergo further stages of drug development to overcome their toxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 18201-65-5
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Appearance Solid
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Molecular Weight 282.12
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Formula C13H9Cl2NO2
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Color White to light yellow
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SMILES
O=C(O)C1=CC=CC=C1NC2=CC(Cl)=CC(Cl)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (354.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5446 mL | 17.7230 mL | 35.4459 mL | 88.6148 mL |
| 5 mM | 0.7089 mL | 3.5446 mL | 7.0892 mL | 17.7230 mL | |
| 10 mM | 0.3545 mL | 1.7723 mL | 3.5446 mL | 8.8615 mL | |
| 15 mM | 0.2363 mL | 1.1815 mL | 2.3631 mL | 5.9077 mL | |
| 20 mM | 0.1772 mL | 0.8861 mL | 1.7723 mL | 4.4307 mL | |
| 25 mM | 0.1418 mL | 0.7089 mL | 1.4178 mL | 3.5446 mL | |
| 30 mM | 0.1182 mL | 0.5908 mL | 1.1815 mL | 2.9538 mL | |
| 40 mM | 0.0886 mL | 0.4431 mL | 0.8861 mL | 2.2154 mL | |
| 50 mM | 0.0709 mL | 0.3545 mL | 0.7089 mL | 1.7723 mL | |
| 60 mM | 0.0591 mL | 0.2954 mL | 0.5908 mL | 1.4769 mL | |
| 80 mM | 0.0443 mL | 0.2215 mL | 0.4431 mL | 1.1077 mL | |
| 100 mM | 0.0354 mL | 0.1772 mL | 0.3545 mL | 0.8861 mL |
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