1. Neuronal Signaling
  2. Transthyretin (TTR)
  3. Dichlorophenyl-ABA

Dichlorophenyl-ABA is an inhibitor of transthyretin (TTR) amyloid fibril formation, inhibiting aggregate formation in more than 80% in TTR L55P-expressing cells.

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Dichlorophenyl-ABA Chemical Structure

Dichlorophenyl-ABA Chemical Structure

CAS No. : 18201-65-5

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1 mg USD 160 In-stock
5 mg USD 350 In-stock
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50 mg USD 1850 In-stock
100 mg USD 2960 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Dichlorophenyl-ABA is an inhibitor of transthyretin (TTR) amyloid fibril formation, inhibiting aggregate formation in more than 80% in TTR L55P-expressing cells[1].

IC50 & Target

Transthyretin (TTR) amyloid fibril formation

In Vitro

Dichlorophenyl-ABA (DCPA) is able to prevent L55P aggregate formation in the conditioned medium. With regard to the ultrastructural analysis, Dichlorophenyl-ABA does not show an inhibitory effect as high as DFPB and benzoxazole, indicating that the Y78F mutant may not be as sensitive to this drug as TTR L55P and V30M are[1].
Dichlorophenyl-ABA is the best stabilizers of V30M tetramers in plasma from carriers of this mutant, and clearly inhibit aggregation in the cellular system. Therefore Dichlorophenyl-ABA is promising for the treatment of valine at position 30 (V30M)-associated familial amyloidotic polyneuropathy (FAP) but need to undergo further stages of drug development to overcome their toxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

282.12

Formula

C13H9Cl2NO2

CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(O)C1=CC=CC=C1NC2=CC(Cl)=CC(Cl)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (354.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5446 mL 17.7230 mL 35.4459 mL
5 mM 0.7089 mL 3.5446 mL 7.0892 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation

Purity: ≥99.0%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5446 mL 17.7230 mL 35.4459 mL 88.6148 mL
5 mM 0.7089 mL 3.5446 mL 7.0892 mL 17.7230 mL
10 mM 0.3545 mL 1.7723 mL 3.5446 mL 8.8615 mL
15 mM 0.2363 mL 1.1815 mL 2.3631 mL 5.9077 mL
20 mM 0.1772 mL 0.8861 mL 1.7723 mL 4.4307 mL
25 mM 0.1418 mL 0.7089 mL 1.4178 mL 3.5446 mL
30 mM 0.1182 mL 0.5908 mL 1.1815 mL 2.9538 mL
40 mM 0.0886 mL 0.4431 mL 0.8861 mL 2.2154 mL
50 mM 0.0709 mL 0.3545 mL 0.7089 mL 1.7723 mL
60 mM 0.0591 mL 0.2954 mL 0.5908 mL 1.4769 mL
80 mM 0.0443 mL 0.2215 mL 0.4431 mL 1.1077 mL
100 mM 0.0354 mL 0.1772 mL 0.3545 mL 0.8861 mL
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Dichlorophenyl-ABA Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Dichlorophenyl-ABA
Cat. No.:
HY-113950
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