EMP3 - epithelial membrane protein 3 Gene

Also Known as YMP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2014

About EMP3

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,325,552-48,330,553 (from NCBI)

This gene has 9 transcripts (splice variants), 239 orthologues and 10 paralogues. Ubiquitous expression in bone marrow (RPKM 63.7), appendix (RPKM 40.0) and 24 other tissues.

Summary

The protein encoded by this gene belongs to the PMP-22/EMP/MP20 family of proteins. The protein contains four transmembrane domains and two N-linked glycosylation sites. It is thought to be involved in cell proliferation, cell-cell interactions and function as a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

EMP3 Products (2)

mRNA Protein Name
NM_001313905.1 NP_001300834.1 epithelial membrane protein 3
NM_001425.3 NP_001416.1 epithelial membrane protein 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12107182 GOA
Biological Process GO Annotation Evidence References Source
involved in apoptotic process IDA
IDA: Inferred from direct assay
12107182 GOA
involved in bleb assembly IDA
IDA: Inferred from direct assay
12107182 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
12107182 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EMP3 Protein Structure

PMP22_Claudin

PMP22_Claudin: PMP-22/EMP/MP20/Claudin family (1 - 156)

  • 0
  • 100
  • 163 a.a.
Protein Preferred Names Protein Names

epithelial membrane protein 3

  • EMP-3

EMP3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EMP3 P54852 LDLRAD1 Homo sapiens Q5T700
Validated Y2H
32296183
Intra
EMP3 P54852 LDLRAD1 Homo sapiens Q5T700
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 LDLRAD1 Homo sapiens Q5T700
Y2H Array
32296183
Intra
EMP3 P54852 ELOVL7 Homo sapiens A1L3X0
Y2H Array
32296183
Intra
EMP3 P54852 ELOVL7 Homo sapiens A1L3X0
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 LYVE1 Homo sapiens Q9Y5Y7
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 LYVE1 Homo sapiens Q9Y5Y7
Validated Y2H
32296183
Intra
EMP3 P54852 LYVE1 Homo sapiens Q9Y5Y7
Y2H Array
32296183
Intra
EMP3 P54852 RMDN3 Homo sapiens Q96TC7
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 RMDN3 Homo sapiens Q96TC7
Y2H Array
32296183
Intra
EMP3 P54852 RMDN3 Homo sapiens Q96TC7
Validated Y2H
32296183
Intra
EMP3 P54852 FNDC9 Homo sapiens Q8TBE3
Y2H Array
32296183
Intra
EMP3 P54852 FNDC9 Homo sapiens Q8TBE3
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 FNDC9 Homo sapiens Q8TBE3
Validated Y2H
32296183
Intra
EMP3 P54852 MR1 Homo sapiens Q95460-2
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 MR1 Homo sapiens Q95460-2
Validated Y2H
32296183
Intra
EMP3 P54852 MR1 Homo sapiens Q95460-2
Y2H Array
32296183
Intra
EMP3 P54852 MS4A3 Homo sapiens Q96HJ5
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 MS4A3 Homo sapiens Q96HJ5
Validated Y2H
32296183
Intra
EMP3 P54852 MS4A3 Homo sapiens Q96HJ5
Y2H Array
32296183
Intra
EMP3 P54852 OPRM1 Homo sapiens P35372-10
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 OPRM1 Homo sapiens P35372-10
Y2H Array
32296183
Intra
EMP3 P54852 GPR61 Homo sapiens Q9BZJ8
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 GPR61 Homo sapiens Q9BZJ8
Y2H Array
32296183
Intra
EMP3 P54852 GPR61 Homo sapiens Q9BZJ8
Validated Y2H
32296183
Intra
EMP3 P54852 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
EMP3 P54852 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra
EMP3 P54852 TM4SF18 Homo sapiens Q96CE8
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 TM4SF18 Homo sapiens Q96CE8
Validated Y2H
32296183
Intra
EMP3 P54852 TM4SF18 Homo sapiens Q96CE8
Y2H Array
32296183
Intra
EMP3 P54852 HTATIP2 Homo sapiens Q9BUP3
Ub Reconstruction
30614533
Intra
EMP3 P54852 HTATIP2 Homo sapiens Q9BUP3
BiFC
30614533
Intra
EMP3 P54852 HTATIP2 Homo sapiens Q9BUP3
PLA
30614533
Intra
EMP3 P54852 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
Intra
EMP3 P54852 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 KIR3DL3 Homo sapiens Q8N743
Validated Y2H
32296183
Intra
EMP3 P54852 KIR3DL3 Homo sapiens Q8N743
Y2H Array
32296183
Intra
EMP3 P54852 KIR3DL3 Homo sapiens Q8N743
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 SLC35C2 Homo sapiens Q9NQQ7-3
Validated Y2H
32296183
Intra
EMP3 P54852 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra
EMP3 P54852 LEUTX Homo sapiens A8MZ59
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 LEUTX Homo sapiens A8MZ59
Y2H Array
32296183
Intra
EMP3 P54852 SPACA1 Homo sapiens Q9HBV2
Validated Y2H
32296183
Intra
EMP3 P54852 SPACA1 Homo sapiens Q9HBV2
Y2H Array
32296183
Intra
EMP3 P54852 SPACA1 Homo sapiens Q9HBV2
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 GJB1 Homo sapiens P08034
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 GJB1 Homo sapiens P08034
Y2H Array
32296183
Intra
EMP3 P54852 IL3RA Homo sapiens P26951
Y2H Array
32296183
Intra
EMP3 P54852 IL3RA Homo sapiens P26951
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 SIGLECL1 Homo sapiens Q8N7X8
Y2H Array
32296183
Intra
EMP3 P54852 SIGLECL1 Homo sapiens Q8N7X8
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 SIGLECL1 Homo sapiens Q8N7X8
Validated Y2H
32296183
Intra
EMP3 P54852 SLAMF8 Homo sapiens Q9P0V8
Validated Y2H
32296183
Intra
EMP3 P54852 SLAMF8 Homo sapiens Q9P0V8
Y2H Array
32296183
Intra
EMP3 P54852 SLAMF8 Homo sapiens Q9P0V8
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 VSIG1 Homo sapiens Q86XK7
Validated Y2H
32296183
Intra
EMP3 P54852 VSIG1 Homo sapiens Q86XK7
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 VSIG1 Homo sapiens Q86XK7
Y2H Array
32296183
Intra
EMP3 P54852 FAM210B Homo sapiens Q96KR6
Y2H Array
32296183
Intra
EMP3 P54852 FAM210B Homo sapiens Q96KR6
Validated Y2H
32296183
Intra
EMP3 P54852 FAM210B Homo sapiens Q96KR6
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 TSPAN12 Homo sapiens O95859
Y2H Array
32296183
Intra
EMP3 P54852 TSPAN12 Homo sapiens O95859
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 CMTM5 Homo sapiens Q96DZ9
Ub Reconstruction
30614533
Intra
EMP3 P54852 LHFPL5 Homo sapiens Q8TAF8
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 LHFPL5 Homo sapiens Q8TAF8
Validated Y2H
32296183
Intra
EMP3 P54852 LHFPL5 Homo sapiens Q8TAF8
Y2H Array
32296183
Intra
EMP3 P54852 SECTM1 Homo sapiens Q8WVN6
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 SECTM1 Homo sapiens Q8WVN6
Validated Y2H
32296183
Intra
EMP3 P54852 SECTM1 Homo sapiens Q8WVN6
Y2H Array
32296183
Intra
EMP3 P54852 PLEKHB2 Homo sapiens Q96CS7
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 PLEKHB2 Homo sapiens Q96CS7
Validated Y2H
32296183
Intra
EMP3 P54852 PLEKHB2 Homo sapiens Q96CS7
Y2H Array
32296183
Intra
EMP3 P54852 IFNGR2 Homo sapiens P38484
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 IFNGR2 Homo sapiens P38484
Y2H Array
32296183
Intra
EMP3 P54852 SAR1A Homo sapiens Q9NR31
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 SAR1A Homo sapiens Q9NR31
Validated Y2H
32296183
Intra
EMP3 P54852 SAR1A Homo sapiens Q9NR31
Y2H Array
32296183
Intra
EMP3 P54852 LRRC4C Homo sapiens Q9HCJ2
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 LRRC4C Homo sapiens Q9HCJ2
Y2H Array
32296183
Intra
EMP3 P54852 LRRC4C Homo sapiens Q9HCJ2
Validated Y2H
32296183
Intra
EMP3 P54852 GPA33 Homo sapiens Q99795
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 GPA33 Homo sapiens Q99795
Validated Y2H
32296183
Intra
EMP3 P54852 GPA33 Homo sapiens Q99795
Y2H Array
32296183
Intra
EMP3 P54852 EDA Homo sapiens Q92838
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 EDA Homo sapiens Q92838
Y2H Array
31515488
Intra
EMP3 P54852 EDA Homo sapiens Q92838
Validated Y2H
25416956
Intra
EMP3 P54852 EDA Homo sapiens Q92838
Validated Y2H
32296183
Intra
EMP3 P54852 EDA Homo sapiens Q92838
Y2H Array
25416956
Intra
EMP3 P54852 EDA Homo sapiens Q92838
Y2H Array
32296183
Intra
EMP3 P54852 RAP2A Homo sapiens P10114
Ub Reconstruction
30614533
Intra
EMP3 P54852 FLOT1 Homo sapiens O75955
Ub Reconstruction
30614533
Intra
EMP3 P54852 PLP2 Homo sapiens Q04941
PLA
30614533
Intra
EMP3 P54852 PLP2 Homo sapiens Q04941
BiFC
30614533
Intra
EMP3 P54852 PLP2 Homo sapiens Q04941
Ub Reconstruction
30614533
Intra
EMP3 P54852 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
EMP3 P54852 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
EMP3 P54852 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
EMP3 P54852 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
EMP3 P54852 BSDC1 Homo sapiens Q9NW68
BiFC
30614533
Intra
EMP3 P54852 BSDC1 Homo sapiens Q9NW68
Ub Reconstruction
30614533
Intra
EMP3 P54852 BSDC1 Homo sapiens Q9NW68
PLA
30614533
Intra
EMP3 P54852 VAMP3 Homo sapiens Q15836
Ub Reconstruction
30614533
Intra
EMP3 P54852 TMEM51 Homo sapiens Q9NW97
Ub Reconstruction
30614533
Intra
EMP3 P54852 CLDN7 Homo sapiens O95471
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 CLDN7 Homo sapiens O95471
Y2H Array
32296183
Intra
EMP3 P54852 SMIM3 Homo sapiens Q9BZL3
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 SMIM3 Homo sapiens Q9BZL3
Validated Y2H
32296183
Intra
EMP3 P54852 SMIM3 Homo sapiens Q9BZL3
Y2H Array
32296183
Intra
EMP3 P54852 GJA5 Homo sapiens P36382
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 GJA5 Homo sapiens P36382
Y2H Array
32296183
Intra
EMP3 P54852 CLDN2 Homo sapiens P57739
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 CLDN2 Homo sapiens P57739
Validated Y2H
32296183
Intra
EMP3 P54852 CLDN2 Homo sapiens P57739
Y2H Array
32296183
Intra
EMP3 P54852 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
EMP3 P54852 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
EMP3 P54852 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
EMP3 P54852 SLC30A2 Homo sapiens Q9BRI3
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 SLC30A2 Homo sapiens Q9BRI3
Validated Y2H
32296183
Intra
EMP3 P54852 KLRC1 Homo sapiens P26715
Y2H Prey Pooling
32296183
Intra
EMP3 P54852 KLRC1 Homo sapiens P26715
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Adult Oligodendroglioma

  • Adult Brain Oligodendroglioma

  • Grade Ii Adult Oligodendroglial Tumor

  • Oligodendroglioma, Adult
Charcot-Marie-Tooth Disease

  • Cmt

  • Hmsn

  • Hereditary Motor And Sensory Neuropathy

  • Pma

  • Cmt - Charcot-Marie-Tooth Disease

  • Charcot Marie Tooth Disease

  • Charcot-Marie-Tooth Hereditary Neuropathy

  • Charcot-Marie-Tooth Syndrome

  • Peroneal Muscular Atrophy

  • Hereditary Motor And Sensory Neuropathies
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04361 EMP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19596 Emp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26092 Emp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris EMP3 VGNC VGNC:40354
Bos taurus EMP3 VGNC VGNC:28483
Macaca mulatta EMP3 VGNC VGNC:72215
Mus musculus EMP3 MGD MGI:1098729
Rattus norvegicus EMP3 RGD RGD:621094
Others EMP3 NCBI