ELOVL7 - ELOVL fatty acid elongase 7 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79993

About ELOVL7

Cytogenetic location: 5q12.1 Genomic coordinates (GRCh38): 5:60,751,791-60,844,269 (from NCBI)

This gene has 7 transcripts (splice variants), 230 orthologues and 6 paralogues. Broad expression in prostate (RPKM 8.7), skin (RPKM 7.9) and 18 other tissues.

Summary

Enables fatty acid elongase activity. Involved in fatty acid elongation, polyunsaturated fatty acid; fatty acid elongation, saturated fatty acid; and very long-chain fatty acid biosynthetic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

ELOVL7 Products (4)

mRNA Protein Name
NM_001104558.2 NP_001098028.1 elongation of very long chain fatty acids protein 7 isoform 1
NM_001297617.2 NP_001284546.1 elongation of very long chain fatty acids protein 7 isoform 2
NM_001297618.2 NP_001284547.1 elongation of very long chain fatty acids protein 7 isoform 3
NM_024930.3 NP_079206.2 elongation of very long chain fatty acids protein 7 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables fatty acid elongase activity EXP
EXP: Inferred from Experiment
19826053 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20937905 GOA
Biological Process GO Annotation Evidence References Source
involved in fatty acid elongation, polyunsaturated fatty acid IDA
IDA: Inferred from direct assay
20937905 GOA
involved in fatty acid elongation, saturated fatty acid IDA
IDA: Inferred from direct assay
19826053 GOA
involved in very long-chain fatty acid biosynthetic process IDA
IDA: Inferred from direct assay
19826053 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
20937905 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ELOVL7 Protein Structure

ELO

ELO: GNS1/SUR4 family (30 - 265)

  • 0
  • 100
  • 200
  • 281 a.a.
Protein Preferred Names Protein Names

elongation of very long chain fatty acids protein 7

  • 3-keto acyl-CoA synthase ELOVL7

ELOVL7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ELOVL7 A1L3X0 RTP2 Homo sapiens Q5QGT7
Validated Y2H
32296183
Intra
ELOVL7 A1L3X0 SYNJ2BP Homo sapiens P57105
Validated Y2H
32296183
Intra
ELOVL7 A1L3X0 ADGRE2 Homo sapiens Q9UHX3
Validated Y2H
32296183
Intra
ELOVL7 A1L3X0 VAMP1 Homo sapiens P23763-3
Validated Y2H
32296183
Intra
ELOVL7 A1L3X0 SLC41A1 Homo sapiens Q8IVJ1
Validated Y2H
32296183
Intra
ELOVL7 A1L3X0 SERF1A Homo sapiens O75920
Validated Y2H
32296183
Intra
ELOVL7 A1L3X0 TMEM14C Homo sapiens Q9P0S9
Validated Y2H
32296183
Intra
ELOVL7 A1L3X0 UBE2J2 Homo sapiens Q8N2K1
Validated Y2H
32296183
Intra
ELOVL7 A1L3X0 EMP3 Homo sapiens P54852
Validated Y2H
32296183
Intra
ELOVL7 A1L3X0 DTNBP1 Homo sapiens Q96EV8
Y2H Array
25416956
Intra
ELOVL7 A1L3X0 LRCH4 Homo sapiens O75427
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spinocerebellar Ataxia 38

  • Spinocerebellar Ataxia Type 38

  • SCA38

  • Ataxia, Spinocerebellar, Type 38
Spinocerebellar Ataxia 34

  • Erythrokeratodermia With Ataxia

  • Spinocerebellar Ataxia Type 34

  • SCA34

  • Erythrokeratodermia - Ataxia

  • Giroux Barbeau Syndrome

  • Spinocerebellar Ataxia And Erythrokeratodermia

  • Erythrokeratodermia Ataxia
Spastic Quadriplegia

  • Spastic Quadriplegic Cerebral Palsy

  • Quadriplegic Infantile Cerebral Palsy

  • Tetraplegic Infantile Cerebral Palsy

  • Cerebral Palsy Spastic Quadriplegic

  • Quadriplegic Cerebral Palsy

  • Spastic Quadriplegia Cerebral Palsy

  • Spastic Tetraplegia Cerebral Palsy

  • Cerebral Palsy, Quadriplegic, Infantile

  • Cerebral Palsy With Spastic Tetraplegia

  • Congenital Spastic Quadriplegia

  • Spastic Tetraplegic Cerebral Palsy

  • Congenital Quadriplegia Nos

  • Tetraplegic Cerebral Palsy
Erythrokeratodermia Variabilis Et Progressiva 1

  • Erythrokeratodermia Variabilis

  • Erythrokeratodermia Variabilis Et Progressiva

  • Greither Disease

  • Ekv

  • Ekvp

  • PSEK

  • Erythrokeratodermia Variabilis With Erythema Gyratum Repens

  • Keratosis Palmoplantaris Transgrediens Et Progrediens

  • Transgrediens Et Progrediens Palmoplantar Keratoderma

  • EKVP1

  • Erythrokeratodermia, Progressive Symmetric

  • Erythrokeratodermia Figurata, Congenital Familial, In Plaques

  • Keratoderma Palmoplantaris Transgrediens

  • Keratosis Extremitatum Hereditaria Progrediens

  • Erythrokeratodermia Variabilis, Mendes Da Costa Type

  • Progressive Symmetric Erythrokeratodermia

  • Erythrokeratodermia Figurata Variabilis

  • Greither'S Disease

  • Ekv-P

  • Erythrokeratodermia Variabilis Of Mendes Da Costa

  • Progressive Symmetrical Erythrokeratoderma Of Gottron

  • Progressive Diffuse Ppk

  • Progressive Diffuse Palmoplantar Keratoderma

  • Transgrediens Et Progrediens Ppk

  • Darier-Gottron Disease

  • Erythrokeratodermia Progressiva Symmetrica

  • Progressive Symmetric Erythrokeratodermia, Gottron Type

  • Congenital Familial Erythrokeratodermia Figurata In Plaques

  • Erythrokeratodermia Progressive Symmetric

  • Erythrokeratodermia Variabilis Mendes Da Costa Type
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04327 ELOVL7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ELOVL7 VGNC VGNC:72117
Felis catus ELOVL7 VGNC VGNC:61825
Mus musculus ELOVL7 MGD MGI:1921809
Rattus norvegicus ELOVL7 RGD RGD:1310560
Canis familiaris ELOVL7 VGNC VGNC:40325
Bos taurus ELOVL7 VGNC VGNC:28453
Others ELOVL7 NCBI