2. Gene
  3. ADGRE2 - adhesion G protein-coupled receptor E2 Gene

ADGRE2 - adhesion G protein-coupled receptor E2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as VBU; CD97; EMR2; CD312

Gene ID: 30817 | Gene type: protein coding

About ADGRE2

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:14,724,171-14,778,560 (from NCBI)

This gene has 13 transcripts (splice variants), 82 orthologues, 42 paralogues and is associated with 2 phenotypes. Broad expression in appendix (RPKM 10.8), spleen (RPKM 6.1) and 16 other tissues.

Summary

This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

ADGRE2 Products(4)

mRNA Protein Name
NM_001271052.1 NP_001257981.1 adhesion G protein-coupled receptor E2 isoform h precursor
NM_013447.4 NP_038475.2 adhesion G protein-coupled receptor E2 isoform a precursor
NM_152916.2 NP_690880.1 adhesion G protein-coupled receptor E2 isoform b precursor
NM_152917.2 NP_690881.1 adhesion G protein-coupled receptor E2 isoform c precursor

ADGRE2 Protein Structure

EGF_CA

EGF_CA: Calcium-binding EGF domain (67 - 117)

EGF_CA

EGF_CA: Calcium-binding EGF domain (119 - 157)

EGF_CA

EGF_CA: Calcium-binding EGF domain (163 - 210)

EGF_CA

EGF_CA: Calcium-binding EGF domain (212 - 259)

GPS

GPS: GPCR proteolysis site, GPS, motif (480 - 524)

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (535 - 774)

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  • 823 a.a.
Protein Preferred Names Protein Names

adhesion G protein-coupled receptor E2

CD97 antigen

Recombinant ADGRE2 Proteins

Cat. No. Product Name Accession Purity
HY-P79159 EMR2 Protein, Human (CHO, His) AAI27005.1 (Q24-Q478) ≥95%

Related Diseases

Diseases Alias
Vibratory Urticaria

Vibratory Angioedema

Dermodistortive Urticaria

VBU

Ddu

Angioedema, Vibratory
Urticaria

Nettle Rash

Hives

Wheal

Urticaria Nos
Physical Urticaria

Symptomatic Dermographism
Hereditary Alpha Tryptasemia Syndrome
Polymicrogyria, Bilateral Frontoparietal

Bilateral Frontoparietal Polymicrogyria

BFPP

Cerebellar Ataxia With Neuronal Migration Defect
Dermatographia

Dermatographic Urticaria

Dermographism

Symptomatic Dermographism

Urticaria Factitia

Factitious Urticaria

Dermatographism
Usher Syndrome, Type Iic

Usher Syndrome Type 2c

USH2C

Usher Syndrome, Type 2c

Usher Syndrome, Type Iic, Gpr98/Pdzd7 Digenic

Usher Syndrome Type Iic

Usher Syndrome, Type 2c, Gpr98/Pdzd7 Digenic

Usher Syndrome 2c

Usher'S Syndrome Type 2c

Usher Syndrome Type Iic Gpr98/Pdzd7 Digenic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00350 ADGRE2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ADGRE2 MGD MGI:1347095