ADGRE2 - adhesion G protein-coupled receptor E2 Gene

Also Known as VBU; CD97; EMR2; CD312

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 30817

About ADGRE2

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:14,724,171-14,778,560 (from NCBI)

This gene has 13 transcripts (splice variants), 82 orthologues, 42 paralogues and is associated with 2 phenotypes. Broad expression in appendix (RPKM 10.8), spleen (RPKM 6.1) and 16 other tissues.

Summary

This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

ADGRE2 Products (4)

mRNA Protein Name
NM_001271052.1 NP_001257981.1 adhesion G protein-coupled receptor E2 isoform h precursor
NM_013447.4 NP_038475.2 adhesion G protein-coupled receptor E2 isoform a precursor
NM_152916.2 NP_690880.1 adhesion G protein-coupled receptor E2 isoform b precursor
NM_152917.2 NP_690881.1 adhesion G protein-coupled receptor E2 isoform c precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chondroitin sulfate binding IMP
IMP: Inferred from mutant phenotype
12829604 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
31273197 GOA
Biological Process GO Annotation Evidence References Source
involved in cell adhesion IMP
IMP: Inferred from mutant phenotype
12829604 GOA
involved in cell migration IMP
IMP: Inferred from mutant phenotype
17928360 GOA
involved in granulocyte chemotaxis IMP
IMP: Inferred from mutant phenotype
17928360 GOA
involved in regulation of mast cell degranulation IMP
IMP: Inferred from mutant phenotype
26841242 GOA
Cellular Component GO Annotation Evidence References Source
located in leading edge membrane IDA
IDA: Inferred from direct assay
17928360 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADGRE2 Protein Structure

EGF_CA

EGF_CA: Calcium-binding EGF domain (67 - 117)

EGF_CA

EGF_CA: Calcium-binding EGF domain (119 - 157)

EGF_CA

EGF_CA: Calcium-binding EGF domain (163 - 210)

EGF_CA

EGF_CA: Calcium-binding EGF domain (212 - 259)

GPS

GPS: GPCR proteolysis site, GPS, motif (480 - 524)

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (535 - 774)

  • 0
  • 200
  • 400
  • 600
  • 823 a.a.
Protein Preferred Names Protein Names

adhesion G protein-coupled receptor E2

  • CD97 antigen

ADGRE2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ADGRE2 Q9UHX3 ELOVL7 Homo sapiens A1L3X0
Y2H Prey Pooling
32296183
Intra
ADGRE2 Q9UHX3 ELOVL7 Homo sapiens A1L3X0
Y2H Array
32296183
Intra
ADGRE2 Q9UHX3 TMEM80 Homo sapiens Q96HE8
Y2H Prey Pooling
32296183
Intra
ADGRE2 Q9UHX3 TMEM80 Homo sapiens Q96HE8
Y2H Array
32296183
Intra
ADGRE2 Q9UHX3 TLCD4 Homo sapiens Q96MV1
Y2H Array
32296183
Intra
ADGRE2 Q9UHX3 TLCD4 Homo sapiens Q96MV1
Y2H Prey Pooling
32296183
Intra
ADGRE2 Q9UHX3 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
ADGRE2 Q9UHX3 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
ADGRE2 Q9UHX3 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra
ADGRE2 Q9UHX3 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra
ADGRE2 Q9UHX3 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
ADGRE2 Q9UHX3 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
ADGRE2 Q9UHX3 ELOVL4 Homo sapiens Q9GZR5
Y2H Prey Pooling
32296183
Intra
ADGRE2 Q9UHX3 ELOVL4 Homo sapiens Q9GZR5
Y2H Array
32296183
Intra
ADGRE2 Q9UHX3 MARCHF6 Homo sapiens O60337
Y2H Prey Pooling
32296183
Intra
ADGRE2 Q9UHX3 MARCHF6 Homo sapiens O60337
Y2H Array
32296183
Intra
ADGRE2 Q9UHX3 SAR1A Homo sapiens Q9NR31
Y2H Prey Pooling
32296183
Intra
ADGRE2 Q9UHX3 SAR1A Homo sapiens Q9NR31
Y2H Array
32296183
Intra
ADGRE2 Q9UHX3 MFSD5 Homo sapiens Q6N075
Y2H Prey Pooling
32296183
Intra
ADGRE2 Q9UHX3 MFSD5 Homo sapiens Q6N075
Y2H Array
32296183
Intra
ADGRE2 Q9UHX3 SLC7A14 Homo sapiens Q8TBB6
Y2H Prey Pooling
32296183
Intra
ADGRE2 Q9UHX3 SLC7A14 Homo sapiens Q8TBB6
Y2H Array
32296183
Intra
ADGRE2 Q9UHX3 MMGT1 Homo sapiens Q8N4V1
Y2H Array
32296183
Intra
ADGRE2 Q9UHX3 MMGT1 Homo sapiens Q8N4V1
Y2H Prey Pooling
32296183
Intra
ADGRE2 Q9UHX3 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
ADGRE2 Q9UHX3 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
ADGRE2 Q9UHX3 BIK Homo sapiens Q13323
Y2H Prey Pooling
32296183
Intra
ADGRE2 Q9UHX3 MTERF3 Homo sapiens Q96E29
Y2H Prey Pooling
32296183
Intra
ADGRE2 Q9UHX3 MTERF3 Homo sapiens Q96E29
Y2H Array
32296183
Intra
ADGRE2 Q9UHX3 KIR2DL3 Homo sapiens P43628
Y2H Prey Pooling
32296183
Intra
ADGRE2 Q9UHX3 KIR2DL3 Homo sapiens P43628
Y2H Array
32296183
Intra
ADGRE2 Q9UHX3 CCDC107 Homo sapiens Q8WV48
Y2H Array
32296183
Intra
ADGRE2 Q9UHX3 CCDC107 Homo sapiens Q8WV48
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Vibratory Urticaria

  • Vibratory Angioedema

  • Dermodistortive Urticaria

  • VBU

  • Ddu

  • Angioedema, Vibratory
Urticaria

  • Nettle Rash

  • Hives

  • Wheal

  • Urticaria Nos
Physical Urticaria

  • Symptomatic Dermographism
Hereditary Alpha Tryptasemia Syndrome
Polymicrogyria, Bilateral Frontoparietal

  • Bilateral Frontoparietal Polymicrogyria

  • BFPP

  • Cerebellar Ataxia With Neuronal Migration Defect
Dermatographia

  • Dermatographic Urticaria

  • Dermographism

  • Symptomatic Dermographism

  • Urticaria Factitia

  • Factitious Urticaria

  • Dermatographism
Usher Syndrome, Type Iic

  • Usher Syndrome Type 2c

  • USH2C

  • Usher Syndrome, Type 2c

  • Usher Syndrome, Type Iic, Gpr98/Pdzd7 Digenic

  • Usher Syndrome Type Iic

  • Usher Syndrome, Type 2c, Gpr98/Pdzd7 Digenic

  • Usher Syndrome 2c

  • Usher'S Syndrome Type 2c

  • Usher Syndrome Type Iic Gpr98/Pdzd7 Digenic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00350 ADGRE2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992226 Anti-EMR2 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ADGRE2 MGD MGI:1347095
Others ADGRE2 NCBI