SAR1A - secretion associated Ras related GTPase 1A Gene

Also Known as SAR1; Sara; SARA1; masra2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 56681

About SAR1A

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:70,147,289-70,170,514 (from NCBI)

This gene has 8 transcripts (splice variants), 121 orthologues and 30 paralogues. Ubiquitous expression in fat (RPKM 47.2), placenta (RPKM 41.9) and 25 other tissues.

Summary

Predicted to enable GTPase activity. Involved in COPII-coated vesicle cargo loading. Part of COPII vesicle coat. [provided by Alliance of Genome Resources, Apr 2022]

SAR1A Products (2)

mRNA	Protein	Name
NM_001142648.2	NP_001136120.1	GTP-binding protein SAR1a
NM_020150.5	NP_064535.1	GTP-binding protein SAR1a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G protein activity	IDA IDA: Inferred from direct assay	32358066	GOA
enables amino acid sensor activity	IDA IDA: Inferred from direct assay	34290409	GOA
enables amino acid sensor activity	IMP IMP: Inferred from mutant phenotype	34290409	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19181664	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in COPII vesicle coating	IDA IDA: Inferred from direct assay	32358066	GOA
involved in COPII vesicle coating	IMP IMP: Inferred from mutant phenotype	23433038	GOA
involved in COPII-coated vesicle cargo loading	IDA IDA: Inferred from direct assay	17499046	GOA
involved in COPII-coated vesicle cargo loading	IMP IMP: Inferred from mutant phenotype	23433038	GOA
involved in cellular response to leucine starvation	IMP IMP: Inferred from mutant phenotype	34290409	GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IDA IDA: Inferred from direct assay	23433038	GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	23433038	GOA
NOT involved in lipoprotein transport	IDA IDA: Inferred from direct assay	32358066	GOA
involved in negative regulation of TORC1 signaling	IMP IMP: Inferred from mutant phenotype	34290409	GOA
involved in regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	34290409	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of COPII vesicle coat	IDA IDA: Inferred from direct assay	17499046	GOA
is active in endoplasmic reticulum exit site	IDA IDA: Inferred from direct assay	23433038	GOA
is active in endoplasmic reticulum exit site	IMP IMP: Inferred from mutant phenotype	23433038	GOA
is active in lysosomal membrane	IDA IDA: Inferred from direct assay	34290409	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SAR1A Protein Structure

Arf

0
100
198 a.a.

Protein Preferred Names	Protein Names
GTP-binding protein SAR1a	COPII-associated small GTPase

SAR1A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SAR1A	Q9NR31	JAGN1	Homo sapiens	Q8N5M9	Y2H Array	32296183
Intra	SAR1A	Q9NR31	SLC38A7	Homo sapiens	Q9NVC3	Validated Y2H	32296183
Intra	SAR1A	Q9NR31	SERP1	Homo sapiens	Q9Y6X1	Validated Y2H	32296183
Intra	SAR1A	Q9NR31	ORMDL1	Homo sapiens	Q9P0S3	Validated Y2H	32296183
Intra	SAR1A	Q9NR31	ADGRE2	Homo sapiens	Q9UHX3	Validated Y2H	32296183
Intra	SAR1A	Q9NR31	AIG1	Homo sapiens	Q9NVV5-2	Validated Y2H	32296183
Intra	SAR1A	Q9NR31	MARCHF5	Homo sapiens	Q9NX47	Validated Y2H	32296183
Intra	SAR1A	Q9NR31	UBIAD1	Homo sapiens	Q9Y5Z9	Validated Y2H	32296183
Intra	SAR1A	Q9NR31	NAT8	Homo sapiens	Q9UHE5	Validated Y2H	32296183
Intra	SAR1A	Q9NR31	PLLP	Homo sapiens	Q9Y342	Validated Y2H	32296183
Intra	SAR1A	Q9NR31	SAR1B	Homo sapiens	Q9Y6B6	Anti Tag CoIP	33961781
Intra	SAR1A	Q9NR31	SAR1B	Homo sapiens	Q9Y6B6	Anti Tag CoIP	28514442
Intra	SAR1A	Q9NR31	GOLT1B	Homo sapiens	Q9Y3E0	Validated Y2H	32296183
Intra	SAR1A	Q9NR31	ERG28	Homo sapiens	Q9UKR5	Validated Y2H	32296183
Intra	SAR1A	Q9NR31	STX8	Homo sapiens	Q9UNK0	Validated Y2H	32296183
Cross	SAR1A	Q9NR31	Sec23a	Mus musculus	Q01405	Pull Down	19822759

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spondyloepiphyseal Dysplasia Tarda, X-Linked	Spondyloepiphyseal Dysplasia Tarda X-Linked Spondyloepiphyseal Dysplasia Tarda SEDT Sed Tarda, X-Linked Spondyloepiphyseal Dysplasia, Late Spondyloepiphyseal Dysplasia Tarda X-Linked Sed X Linked Spondyloepiphyseal Dysplasia Tarda X-Linked Spondyloepiphyseal Dysplasia Late Onset Spondyloepiphyseal Dysplasia Sed Tarda X-Linked Sed X-Linked Sedt Dysplasia, Spondyloepiphyseal, Tarda Spondyloepiphyseal Dysplasia
Chylomicron Retention Disease	CMRD Anderson Disease Lipid Transport Defect Of Intestine Hypobetalipoproteinemia With Accumulation Of Apolipoprotein B-Like Protein In Intestinal Cells Andd Anderson Syndrome Crd Andersons Disease Malabsorption Syndrome
Craniolenticulosutural Dysplasia	Boyadjiev-Jabs Syndrome CLSD Cranio-Lenticulo-Sutural Dysplasia Cranio-Lenticulo-Sutural Dysplasia, Clsd
Oculomotor Nerve Paralysis	Iii Nerve Palsy Iiird Nerve Paralysis Third Cranial Nerve Paralysis
Intracranial Hypotension

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12442	SAR1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20487	Sar1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26995	Sar1a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SAR1A	VGNC	VGNC:76969
Bos taurus	SAR1A	VGNC	VGNC:34286
Rattus norvegicus	SAR1A	RGD	RGD:1359540
Mus musculus	SAR1A	MGD	MGI:98230
Others	SAR1A	NCBI