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51026

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By Targets:	Amyloid-β (1) Apoptosis (3) Autophagy (1) Btk (1) c-Myc (1) CDK (2) Epoxide Hydrolase (2) HDAC (1) Influenza Virus (1) MicroRNA (8) Photosystem II (1) Ser/Thr Kinase (1)
By Research Areas:	Cancer (12) Inflammation/Immunology (1) Neurological Disease (3)
Oligonucleotides:	miRNA mimics (2) miRNA antagomirs (2) miRNA agomirs (2) MicroRNAs (8) miRNA inhibitors (2)

Inhibitors & Agonists

Inhibitory Antibodies

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112215

Nemtabrutinib 4 Publications Verification ARQ-531; MK-1026	Btk	Inflammation/Immunology Cancer
Nemtabrutinib (ARQ 531) is a reversible non-covalent and orally active inhibitor of Bruton’s Tyrosine Kinase (BTK), with IC₅₀s of 0.85 nM and 0.39 nM for WT-BTK and C481S-BTK, respectively.

HY-15489

Scriptaid 4 Publications Verification Scriptide; GCK1026	HDAC Autophagy Apoptosis Influenza Virus	Cancer
Scriptaid is a potent histone deacetylase (HDAC) inhibitor, used in cancer research. Scriptaid is also a sensitizer to antivirals and has potential for epstein-barr virus (EBV)-associated lymphomas treatment.

HY-135653

EC5026 1 Publications Verification BPN-19186	Epoxide Hydrolase	Neurological Disease
EC5026 (BPN-19186) is a first-in-class, non-opioid and orally active soluble Epoxide Hydrolase (sEH) inhibitor. EC5026 shows efficacy for inflammatory and neuropathic pain .

HY-P99835

Crenezumab MABT 5102A; RG 7412	Amyloid-β	Neurological Disease
Crenezumab (MABT 5102A; RG 7412) is a fully humanized anti-Aβ monoclonal antibody that binds multiple forms of Aβ, such as soluble, oligomeric and fibrillar, for use in Alzheimer's disease research .

HY-121242

Buthidazole VEL-5026	Photosystem II	Others
Buthidazole is a selective herbicide for weed control in corn. Buthidazole inhibits photosynthetic electron transport at two distinct sites in the photosynthetic electron transport chain. The major site of inhibition was on the reducing side of photosystem II. Another site of electron transport inhibition is on the oxidizing side of photosystem II. Buthidazole inhibits corn photosynthesis and prevents starch accumulation in bundle sheath chloroplasts and some ultrastructural disruption of mesophyl chloroplasts of corn plants .

HY-123369

BMI-1026	CDK Apoptosis	Cancer
BMI-1026 is a cyclin-dependent kinase 1 (Cdk1) inhibitor with IC₅₀ of 2.3 nM. BMI-1026 induces apoptosis by arresting the G2-M phase .

HY-R03271

*mmu-miR-5126* mimic**	MicroRNA	Cancer
mmu-miR-5126 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-miR-5126 mimic mmu-miR-5126 mimic

HY-R03251

*mmu-miR-5106* mimic**	MicroRNA	Cancer
mmu-miR-5106 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-miR-5106 mimic mmu-miR-5106 mimic

HY-135653A

(Rac)-EC5026 (Rac)-BPN-19186	Epoxide Hydrolase	Neurological Disease
(Rac)-EC5026 ((Rac)-BPN-19186) is a potent piperidine inhibitor of soluble epoxide hydrolase (sEH) extracted from patent WO2019156991A1, page 39, has a K_i of 0.06 nM. (Rac)-EC5026 can be used for the research of Parkinson's disease and dementia with Lewy Bodies (DLB) .

HY-180355

SY-5102	CDK Ser/Thr Kinase c-Myc Apoptosis	Cancer
SY-5102 is a potent, selective and orally active cyclin-dependent kinase (CDK7) inhibitor with a K_d of 0.03 nM. SY-5102 shows anti-proliferative activity against HCC70 cells with an EC₅₀ of 9 nM. SY-5102 can inhibit CDK7-mediated CAK function (downregulate CDK2 Thr160 phosphorylation) and TFIIH transcription function (downregulate RNA polymerase II Ser5 phosphorylation). SY-5102 can induce G2/M cell cycle arrest, downregulate the expression of the oncogene c-Myc, and ultimately trigger cancer cell apoptosis. SY-5102 can be used for the research of triple-negative breast cancer (TNBC) .

HY-R03271A

*mmu-miR-5126* agomir**	MicroRNA	Cancer
mmu-miR-5126 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-5126 agomir mmu-miR-5126 agomir

HY-RI03251A

*mmu-miR-5106* antagomir**	MicroRNA	Cancer
mmu-miR-5106 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-5106 antagomir mmu-miR-5106 antagomir

HY-RI03251

*mmu-miR-5106* inhibitor**	MicroRNA	Cancer
mmu-miR-5106 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-miR-5106 inhibitor mmu-miR-5106 inhibitor

HY-RI03271

*mmu-miR-5126* inhibitor**	MicroRNA	Cancer
mmu-miR-5126 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-miR-5126 inhibitor mmu-miR-5126 inhibitor

HY-R03251A

*mmu-miR-5106* agomir**	MicroRNA	Cancer
mmu-miR-5106 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-5106 agomir mmu-miR-5106 agomir

HY-RI03271A

*mmu-miR-5126* antagomir**	MicroRNA	Cancer
mmu-miR-5126 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-5126 antagomir mmu-miR-5126 antagomir

Cat. No.	Product Name	Target	Research Area	Image

HY-P99835

Crenezumab MABT 5102A; RG 7412	Amyloid-β	Neurological Disease
Crenezumab (MABT 5102A; RG 7412) is a fully humanized anti-Aβ monoclonal antibody that binds multiple forms of Aβ, such as soluble, oligomeric and fibrillar, for use in Alzheimer's disease research .

Host:	Mouse (3) Rabbit (3)
Reactivity:	Human (6) Bovine (1) Mouse (4) Rat (5) Dog (1) Pig (1)
Application:	IHC-P (4) ICC/IF (3) IF-Tissue (3) IP (3) IHC-F (2) WB (6) ChIP (1) FC (1) ELISA (1)
Isotype:	IgG1, Kappa (1) IgG (4)
Conjugation:	Non-conjugated (6)
Clonality:	Monoclonal (6) Recombinant (4)
Modification:	Phosphorylated (1) Unmodified (5)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85410

	Wnt-10b Antibody (YA5102) WNT10B; WNT12; Protein Wnt-10b; Protein Wnt-12	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue	Human, Rat
	Wnt-10b Antibody (YA5102) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Wnt-10b.

HY-P85434

	HLX1 Antibody (YA5126) HLX; HLX1; H2.0-like homeobox protein; Homeobox protein HB24; Homeobox protein HLX1	WB	Human, Mouse, Rat, Bovine, Dog, Pig
	HLX1 Antibody (YA5126) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to HLX1.

HY-P85334

	PRK2 Antibody (YA5026) PKN2; PRK2; PRKCL2; Serine/threonine-protein kinase N2; PKN gamma; Protein kinase C-like 2; Protein-kinase C-related kinase 2	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue, IP, FC	Human, Mouse, Rat
	PRK2 Antibody (YA5026) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to PRK2.

HY-P86868

	EXOC2 Antibody (YA6561) EXOC2 antibody; EXOC2_HUMAN antibody; Exocyst complex component 2 antibody; Exocyst complex component Sec5 antibody; FLJ11026 antibody; SEC5 antibody; SEC5 like 1 antibody; SEC5L1 antibody; Sec5p antibody;	WB, IHC-P	Human, Mouse, Rat
	EXOC2 Antibody (YA6561) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to EXOC2.

HY-P85414

	ACSM3 Antibody (YA5106) ACSM3; SAH; Acyl-coenzyme A synthetase ACSM3; mitochondrial; Acyl-CoA synthetase medium-chain family member 3; Butyrate--CoA ligase 3; Butyryl-coenzyme A synthetase 3; Middle-chain acyl-CoA synthetase 3; Protein SA homolog	WB, ICC/IF, IP, ELISA, IF-Tissue	Human, Mouse, Rat
	ACSM3 Antibody (YA5106) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to ACSM3.

HY-P81299A

	Phospho-PKR (Thr446) Antibody (YA1026) EIF2AK2; PKR; PRKR; Interferon-induced; double-stranded RNA-activated protein kinase; Eukaryotic translation initiation factor 2-alpha kinase 2; eIF-2A protein kinase 2; Interferon-inducible RNA-dependent protein kinase; P1/eIF-2A protein k	WB, IHC-P, IP, ChIP	Human
	Phospho-PKR (Thr446) Antibody (YA1026) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-PKR (Thr446).

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Cat. No.	Product Name		Classification

HY-R03271

*mmu-miR-5126* mimic**		MicroRNAs miRNA mimics
mmu-miR-5126 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-R03251

*mmu-miR-5106* mimic**		MicroRNAs miRNA mimics
mmu-miR-5106 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-R03271A

*mmu-miR-5126* agomir**		MicroRNAs miRNA agomirs
mmu-miR-5126 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI03251A

*mmu-miR-5106* antagomir**		MicroRNAs miRNA antagomirs
mmu-miR-5106 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI03251

*mmu-miR-5106* inhibitor**		MicroRNAs miRNA inhibitors
mmu-miR-5106 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-RI03271

*mmu-miR-5126* inhibitor**		MicroRNAs miRNA inhibitors
mmu-miR-5126 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-R03251A

*mmu-miR-5106* agomir**		MicroRNAs miRNA agomirs
mmu-miR-5106 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI03271A

*mmu-miR-5126* antagomir**		MicroRNAs miRNA antagomirs
mmu-miR-5126 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

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