2095393-15-8
2095393-15-8
Chemical Structure
Nemtabrutinib
Synonym(s): ARQ-531; MK-1026
- CAS No.: 2095393-15-8
- Formula:C25H23ClN4O4
- Molecular Weight:478.93
IUPAC Name: (2-chloro-4-phenoxyphenyl)(4-(((3R,6S)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methanone
InChIKey: JSFCZQSJQXFJDS-QAPCUYQASA-N
SMILES: O=C(C1=C(C=C(OC2=CC=CC=C2)C=C1)Cl)C3=CNC4=NC=NC(N[C@@H]5CC[C@@H](CO)OC5)=C34
Biological Activity: Nemtabrutinib (ARQ 531) is a reversible non-covalent and orally active inhibitor of Bruton’s Tyrosine Kinase (BTK), with IC50s of 0.85 nM and 0.39 nM for WT-BTK and C481S-BTK, respectively.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Nemtabrutinib | 99.32% | Nemtabrutinib (ARQ 531) is a reversible non-covalent and orally active inhibitor of Bruton’s Tyrosine Kinase (BTK), with IC50s of 0.85 nM and 0.39 nM for WT-BTK and C481S-BTK, respectively. | ||||||||||||||||||||
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