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54708

" within the MedChemExpress (MCE) catalog. Here are the results you might be looking for.

By Targets:	Isotope-Labeled Compounds (1) JAK (3) LPL Receptor (1) MicroRNA (12) Neurokinin Receptor (1) Reference Standards (1) Sodium Channel (1) VEGFR (2)
By Research Areas:	Cancer (12) Cardiovascular Disease (3) Inflammation/Immunology (3) Neurological Disease (2)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	miRNA mimics (3) miRNA antagomirs (3) miRNA agomirs (3) MicroRNAs (12) miRNA inhibitors (3)

Inhibitors & Agonists

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-145588

Povorcitinib INCB54707	JAK	Inflammation/Immunology
Povorcitinib (INCB54707) is a potent and selective JAK1 inhibitor that effectively reduces abscesses and inflammatory nodules. Povorcitinib is used to study cutaneous lupus erythematosus (CLE) and lichen planus (LP) .

HY-111253

CYM-5478	LPL Receptor	Neurological Disease
CYM-5478 is a potent and highly selective S1P₂ agonist with an EC₅₀ of 119 nM in a TGFα-shedding assay. CYM-5478 protects neural-derived cell lines against Cisplatin toxicity .

HY-103002

SU5408 5 Publications Verification VEGFR2 Kinase Inhibitor I	VEGFR	Cardiovascular Disease
SU5408 (VEGFR2 Kinase Inhibitor I) is a potent and cell-permeable inhibitor of VEGFR2 kinase with an IC₅₀ of 70 nM.

HY-145588A

Povorcitinib phosphate INCB54707 phosphate	JAK	Inflammation/Immunology
Povorcitinib (INCB54707) phosphate is a potent and selective JAK1 inhibitor that effectively reduces abscesses and inflammatory nodules. Povorcitinib phosphate can be used to study cutaneous lupus erythematosus (CLE) and lichen planus (LP) (information extracted from patent WO2021076124A1) .

HY-R01791

*hsa-miR-5708* mimic**	MicroRNA	Cancer
hsa-miR-5708 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-5708 mimic hsa-miR-5708 mimic

HY-105346

WIN 51708	Neurokinin Receptor	Neurological Disease
WIN 51708 is a nonpeptide antagonist of neurokinin (NK)-1 receptor. WIN 51708 has a higher affinity for the rat NK-1 receptor compared to the human NK-1 receptor .

HY-123427

Transcainide R 54718	Sodium Channel	Cardiovascular Disease
Transcainide (R 54718) is an orally active antiarrhythmic agent .

HY-R01791A

*hsa-miR-5708* agomir**	MicroRNA	Cancer
hsa-miR-5708 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-5708 agomir hsa-miR-5708 agomir

HY-R01292

*hsa-miR-4708-3p mimic*	MicroRNA	Cancer
hsa-miR-4708-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-4708-3p mimic hsa-miR-4708-3p mimic

HY-RI01293A

*hsa-miR-4708-5p antagomir*	MicroRNA	Cancer
hsa-miR-4708-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-4708-5p antagomir hsa-miR-4708-5p antagomir

HY-145588S

Povorcitinib-d6 INCB54707-d₆	Isotope-Labeled Compounds JAK	Inflammation/Immunology
Povorcitinib-d₆ (INCB54707-d₆) is the deuterium labeled Povorcitinib (HY-145588). Povorcitinib (INCB54707) is a potent and selective JAK1 inhibitor that effectively reduces abscesses and inflammatory nodules. Povorcitinib is used to study cutaneous lupus erythematosus (CLE) and lichen planus (LP) .

HY-RI01791

*hsa-miR-5708* inhibitor**	MicroRNA	Cancer
hsa-miR-5708 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-5708 inhibitor hsa-miR-5708 inhibitor

HY-RI01791A

*hsa-miR-5708* antagomir**	MicroRNA	Cancer
hsa-miR-5708 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-5708 antagomir hsa-miR-5708 antagomir

HY-R01292A

*hsa-miR-4708-3p agomir*	MicroRNA	Cancer
hsa-miR-4708-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-4708-3p agomir hsa-miR-4708-3p agomir

HY-RI01292A

*hsa-miR-4708-3p antagomir*	MicroRNA	Cancer
hsa-miR-4708-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-4708-3p antagomir hsa-miR-4708-3p antagomir

HY-R01293A

*hsa-miR-4708-5p agomir*	MicroRNA	Cancer
hsa-miR-4708-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-4708-5p agomir hsa-miR-4708-5p agomir

HY-RI01293

*hsa-miR-4708-5p inhibitor*	MicroRNA	Cancer
hsa-miR-4708-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-4708-5p inhibitor hsa-miR-4708-5p inhibitor

HY-R01293

*hsa-miR-4708-5p mimic*	MicroRNA	Cancer
hsa-miR-4708-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-4708-5p mimic hsa-miR-4708-5p mimic

HY-RI01292

*hsa-miR-4708-3p inhibitor*	MicroRNA	Cancer
hsa-miR-4708-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-4708-3p inhibitor hsa-miR-4708-3p inhibitor

HY-103002R

SU5408 (Standard) VEGFR2 Kinase Inhibitor I (Standard)	Reference Standards VEGFR	Cardiovascular Disease
SU5408 (Standard) is the analytical standard of SU5408 (HY-103002). This product is intended for research and analytical applications. SU5408 (VEGFR2 Kinase Inhibitor I) is a potent and cell-permeable inhibitor of VEGFR2 kinase with an IC₅₀ of 70 nM.

Cat. No.	Product Name	Chemical Structure

HY-145588S

Povorcitinib-d6
Povorcitinib-d₆ (INCB54707-d₆) is the deuterium labeled Povorcitinib (HY-145588). Povorcitinib (INCB54707) is a potent and selective JAK1 inhibitor that effectively reduces abscesses and inflammatory nodules. Povorcitinib is used to study cutaneous lupus erythematosus (CLE) and lichen planus (LP) .

Host:	Mouse (5)
Reactivity:	Human (5) Rat (3) Mouse (3)
Application:	IHC-P (4) ICC/IF (2) IP (1) WB (3) ELISA (1)
Isotype:	IgG1 (1)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (5)
Modification:	Unmodified (5)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86016

	TIMP-1 Antibody (YA5708)	IHC-P, ICC/IF, ELISA	Human
	TIMP-1 Antibody (YA5708) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TIMP-1.

HY-P85778

	Claudin-2 Antibody (YA5470) Claudin-2; SP82;	WB, ICC/IF, IHC-P	Human, Mouse, Rat
	Claudin-2 Antibody (YA5470) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Claudin-2.

HY-P85786

	SphK2 Antibody (YA5478) Sphingosine kinase 2; SK 2; SPK 2;	WB, IHC-P	Human, Mouse, Rat
	SphK2 Antibody (YA5478) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to SphK2.

HY-P85716

	JAK3 Antibody (YA5408) Tyrosine-protein kinase JAK3; Janus kinase 3; JAK-3; Leukocyte janus kinase; L-JAK;	IHC-P	Human, Mouse, Rat
	JAK3 Antibody (YA5408) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to JAK3.

HY-P85508

	Hsp70(C-term) Antibody (YA5200) DAQB 147D11.1 001; FLJ54303; FLJ54370; FLJ54392; FLJ54408; FLJ75127; Heat shock 70 kDa protein 1; Heat shock 70 kDa protein 1/2; Heat shock 70 kDa protein 1A/1B; heat shock 70kDa protein 1A; Heat shock 70kDa protein 1B; Heat shock induced protein; heat shock protein 70; HSP70 1; HSP70 2; HSP70-1/HSP70-2; HSP70-1A; HSP70.1; HSP70.1/HSP70.2; HSP70I; HSP71_HUMAN; HSP72; HSPA1; HSPA1A; HSPA1B; XXbac BCX40G17.3 001.	WB, IP	Human
	Hsp70(C-term) Antibody (YA5200) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Hsp70(C-term).

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Cat. No.	Product Name		Classification

HY-105346

WIN 51708		Alkynes
WIN 51708 is a nonpeptide antagonist of neurokinin (NK)-1 receptor. WIN 51708 has a higher affinity for the rat NK-1 receptor compared to the human NK-1 receptor .

Cat. No.	Product Name		Classification

HY-R01791

*hsa-miR-5708* mimic**		MicroRNAs miRNA mimics
hsa-miR-5708 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-R01791A

*hsa-miR-5708* agomir**		MicroRNAs miRNA agomirs
hsa-miR-5708 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R01292

*hsa-miR-4708-3p mimic*		MicroRNAs miRNA mimics
hsa-miR-4708-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-RI01293A

*hsa-miR-4708-5p antagomir*		MicroRNAs miRNA antagomirs
hsa-miR-4708-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI01791

*hsa-miR-5708* inhibitor**		MicroRNAs miRNA inhibitors
hsa-miR-5708 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-RI01791A

*hsa-miR-5708* antagomir**		MicroRNAs miRNA antagomirs
hsa-miR-5708 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R01292A

*hsa-miR-4708-3p agomir*		MicroRNAs miRNA agomirs
hsa-miR-4708-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI01292A

*hsa-miR-4708-3p antagomir*		MicroRNAs miRNA antagomirs
hsa-miR-4708-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R01293A

*hsa-miR-4708-5p agomir*		MicroRNAs miRNA agomirs
hsa-miR-4708-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI01293

*hsa-miR-4708-5p inhibitor*		MicroRNAs miRNA inhibitors
hsa-miR-4708-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-R01293

*hsa-miR-4708-5p mimic*		MicroRNAs miRNA mimics
hsa-miR-4708-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-RI01292

*hsa-miR-4708-3p inhibitor*		MicroRNAs miRNA inhibitors
hsa-miR-4708-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

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