MARCHF5 - membrane associated ring-CH-type finger 5 Gene

Also Known as MITOL; MARCH5; RNF153; MARCH-V

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54708

Summary

MARCH5 is a ubiquitin Ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2; MIM 608507) and DRP1 (DNM1L; MIM 603850) (Nakamura et al., 2006 [PubMed 16936636]).[supplied by OMIM, Mar 2008]
Ubiquitous expression in thyroid (RPKM 13.2), prostate (RPKM 10.5) and 25 other tissues.

MARCHF5 Products (1)

mRNA Protein Name
NM_017824.5 NP_060294.1 E3 ubiquitin-protein ligase MARCHF5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase binding IPI
IPI: Inferred from physical interaction
16936636 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16874301 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
16936636 GOA
enables ubiquitin protein ligase activity IMP
IMP: Inferred from mutant phenotype
16874301 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of mitochondrial fission IMP
IMP: Inferred from mutant phenotype
20103533 GOA
involved in protein autoubiquitination IDA
IDA: Inferred from direct assay
16874301 GOA
involved in protein localization to mitochondrion IMP
IMP: Inferred from mutant phenotype
17606867 GOA
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
16936636 GOA
involved in regulation of mitochondrial fission IMP
IMP: Inferred from mutant phenotype
16874301 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
14722266 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
14722266 GOA
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
16874301 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MARCHF5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MARCHF5 Q9NX47 UBE2W Homo sapiens Q96FI0
Y2H Array
32296183
Intra
MARCHF5 Q9NX47 UBE2W Homo sapiens Q96FI0
Y2H Prey Pooling
25416956
Intra
MARCHF5 Q9NX47 UBE2W Homo sapiens Q96FI0
Validated Y2H
25416956
Intra
MARCHF5 Q9NX47 UBE2W Homo sapiens Q96FI0
Y2H Prey Pooling
32296183
Intra
MARCHF5 Q9NX47 SGPL1 Homo sapiens O95470
Y2H Prey Pooling
32296183
Intra
MARCHF5 Q9NX47 SGPL1 Homo sapiens O95470
Y2H Array
32296183
Intra
MARCHF5 Q9NX47 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
MARCHF5 Q9NX47 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
MARCHF5 Q9NX47 PTPN5 Homo sapiens P54829
Y2H Array
32296183
Intra
MARCHF5 Q9NX47 PTPN5 Homo sapiens P54829
Y2H Prey Pooling
32296183
Intra
MARCHF5 Q9NX47 ODF4 Homo sapiens Q2M2E3
Y2H Prey Pooling
32296183
Intra
MARCHF5 Q9NX47 ODF4 Homo sapiens Q2M2E3
Y2H Array
32296183
Intra
MARCHF5 Q9NX47 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
MARCHF5 Q9NX47 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
MARCHF5 Q9NX47 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra
MARCHF5 Q9NX47 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra
MARCHF5 Q9NX47 STMN4 Homo sapiens Q9H169-2
Y2H Array
32296183
Intra
MARCHF5 Q9NX47 STMN4 Homo sapiens Q9H169-2
Y2H Prey Pooling
32296183
Intra
MARCHF5 Q9NX47 CGRRF1 Homo sapiens Q99675
Y2H Prey Pooling
32296183
Intra
MARCHF5 Q9NX47 CGRRF1 Homo sapiens Q99675
Y2H Array
32296183
Intra
MARCHF5 Q9NX47 MFN2 Homo sapiens O95140
Anti Tag CoIP
33961781
Intra
MARCHF5 Q9NX47 MFN2 Homo sapiens O95140
Anti Tag CoIP
28514442
Intra
MARCHF5 Q9NX47 UBC Homo sapiens P0CG48
Pull Down
16874301
Intra
MARCHF5 Q9NX47 UBC Homo sapiens P0CG48
Anti Tag CoIP
16874301
Intra
MARCHF5 Q9NX47 MANBAL Homo sapiens Q9NQG1
Y2H Array
32296183
Intra
MARCHF5 Q9NX47 MANBAL Homo sapiens Q9NQG1
Y2H Prey Pooling
32296183
Intra
MARCHF5 Q9NX47 SAR1A Homo sapiens Q9NR31
Y2H Prey Pooling
32296183
Intra
MARCHF5 Q9NX47 SAR1A Homo sapiens Q9NR31
Y2H Array
32296183
Intra
MARCHF5 Q9NX47 BNIP1 Homo sapiens Q12981
Y2H Prey Pooling
32296183
Intra
MARCHF5 Q9NX47 BNIP1 Homo sapiens Q12981
Y2H Array
32296183
Intra
MARCHF5 Q9NX47 TIMMDC1 Homo sapiens Q9NPL8
Y2H Prey Pooling
32296183
Intra
MARCHF5 Q9NX47 TIMMDC1 Homo sapiens Q9NPL8
Y2H Array
32296183
Intra
MARCHF5 Q9NX47 BIK Homo sapiens Q13323
Y2H Prey Pooling
32296183
Intra
MARCHF5 Q9NX47 ANKS6 Homo sapiens Q68DC2
Y2H Prey Pooling
32296183
Intra
MARCHF5 Q9NX47 ANKS6 Homo sapiens Q68DC2
Y2H Array
32296183
Intra
MARCHF5 Q9NX47 UBE2W Homo sapiens Q96B02
Y2H Prey Pooling
25416956
Intra
MARCHF5 Q9NX47 TMEM139 Homo sapiens Q8IV31
Y2H Prey Pooling
32296183
Intra
MARCHF5 Q9NX47 TMEM139 Homo sapiens Q8IV31
Y2H Array
32296183
Intra
MARCHF5 Q9NX47 FATE1 Homo sapiens Q969F0
Validated Y2H
25416956
Intra
MARCHF5 Q9NX47 FATE1 Homo sapiens Q969F0
Y2H Prey Pooling
25416956
Intra
MARCHF5 Q9NX47 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
MARCHF5 Q9NX47 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
MARCHF5 Q9NX47 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
MARCHF5 Q9NX47 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
MARCHF5 Q9NX47 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08143 MARCHF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08144 MARCHF6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown