ORMDL1 - ORMDL sphingolipid biosynthesis regulator 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 94101

Summary

Involved in ceramide metabolic process. Acts upstream of or within negative regulation of ceramide biosynthetic process. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]
Ubiquitous expression in spleen (RPKM 13.3), lymph node (RPKM 13.0) and 25 other tissues.

ORMDL1 Products (7)

mRNA Protein Name
NM_001128150.2 NP_001121622.1 ORM1-like protein 1 isoform 1
NM_001371384.1 NP_001358313.1 ORM1-like protein 1 isoform 4
NM_001371385.1 NP_001358314.1 ORM1-like protein 1 isoform 2
NM_001371386.1 NP_001358315.1 ORM1-like protein 1 isoform 2
NM_001371387.1 NP_001358316.1 ORM1-like protein 1 isoform 3
NM_001371388.1 NP_001358317.1 ORM1-like protein 1 isoform 3
NM_016467.5 NP_057551.1 ORM1-like protein 1 isoform 1

ORMDL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ORMDL1 Q9P0S3 SLC30A8 Homo sapiens Q8IWU4
Y2H Array
32296183
Intra
ORMDL1 Q9P0S3 SLC30A8 Homo sapiens Q8IWU4
Y2H Prey Pooling
32296183
Intra
ORMDL1 Q9P0S3 PGRMC2 Homo sapiens O15173
Y2H Prey Pooling
32296183
Intra
ORMDL1 Q9P0S3 PGRMC2 Homo sapiens O15173
Y2H Array
32296183
Intra
ORMDL1 Q9P0S3 HSD17B11 Homo sapiens Q8NBQ5
Y2H Prey Pooling
32296183
Intra
ORMDL1 Q9P0S3 HSD17B11 Homo sapiens Q8NBQ5
Y2H Array
32296183
Intra
ORMDL1 Q9P0S3 VMA21 Homo sapiens Q3ZAQ7
Y2H Prey Pooling
32296183
Intra
ORMDL1 Q9P0S3 VMA21 Homo sapiens Q3ZAQ7
Y2H Array
32296183
Intra
ORMDL1 Q9P0S3 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
ORMDL1 Q9P0S3 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
ORMDL1 Q9P0S3 TMEM35A Homo sapiens Q53FP2
Y2H Array
32296183
Intra
ORMDL1 Q9P0S3 TMEM35A Homo sapiens Q53FP2
Y2H Prey Pooling
32296183
Intra
ORMDL1 Q9P0S3 STOM Homo sapiens P27105
Y2H Array
32296183
Intra
ORMDL1 Q9P0S3 STOM Homo sapiens P27105
Y2H Prey Pooling
32296183
Intra
ORMDL1 Q9P0S3 ASGR2 Homo sapiens P07307-3
Y2H Prey Pooling
32296183
Intra
ORMDL1 Q9P0S3 ASGR2 Homo sapiens P07307-3
Y2H Array
32296183
Intra
ORMDL1 Q9P0S3 ZDHHC15 Homo sapiens Q96MV8
Y2H Array
32296183
Intra
ORMDL1 Q9P0S3 ZDHHC15 Homo sapiens Q96MV8
Y2H Prey Pooling
32296183
Intra
ORMDL1 Q9P0S3 TLCD4 Homo sapiens Q96MV1
Y2H Prey Pooling
32296183
Intra
ORMDL1 Q9P0S3 TLCD4 Homo sapiens Q96MV1
Y2H Array
32296183
Intra
ORMDL1 Q9P0S3 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
ORMDL1 Q9P0S3 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
ORMDL1 Q9P0S3 TMEM143 Homo sapiens Q96AN5
Y2H Prey Pooling
32296183
Intra
ORMDL1 Q9P0S3 TMEM143 Homo sapiens Q96AN5
Y2H Array
32296183
Intra
ORMDL1 Q9P0S3 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
ORMDL1 Q9P0S3 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
ORMDL1 Q9P0S3 KCNK4 Homo sapiens Q9NYG8-2
Y2H Array
32296183
Intra
ORMDL1 Q9P0S3 KCNK4 Homo sapiens Q9NYG8-2
Y2H Prey Pooling
32296183
Intra
ORMDL1 Q9P0S3 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra
ORMDL1 Q9P0S3 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra
ORMDL1 Q9P0S3 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra
ORMDL1 Q9P0S3 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra
ORMDL1 Q9P0S3 SLC18A1 Homo sapiens P54219-3
Y2H Prey Pooling
32296183
Intra
ORMDL1 Q9P0S3 SLC18A1 Homo sapiens P54219-3
Y2H Array
32296183
Intra
ORMDL1 Q9P0S3 PCNX2 Homo sapiens A6NKB5-5
Y2H Prey Pooling
32296183
Intra
ORMDL1 Q9P0S3 PCNX2 Homo sapiens A6NKB5-5
Y2H Array
32296183
Intra
ORMDL1 Q9P0S3 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra
ORMDL1 Q9P0S3 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra
ORMDL1 Q9P0S3 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra
ORMDL1 Q9P0S3 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
ORMDL1 Q9P0S3 TMEM52B Homo sapiens Q4KMG9
Y2H Array
32296183
Intra
ORMDL1 Q9P0S3 TMEM52B Homo sapiens Q4KMG9
Y2H Prey Pooling
32296183
Intra
ORMDL1 Q9P0S3 RNF5 Homo sapiens Q99942
Y2H Array
32296183
Intra
ORMDL1 Q9P0S3 RNF5 Homo sapiens Q99942
Y2H Prey Pooling
32296183
Intra
ORMDL1 Q9P0S3 MFSD14B Homo sapiens Q5SR56
Y2H Prey Pooling
32296183
Intra
ORMDL1 Q9P0S3 MFSD14B Homo sapiens Q5SR56
Y2H Array
32296183
Intra
ORMDL1 Q9P0S3 ZFYVE27 Homo sapiens Q5T4F4
Y2H Array
32296183
Intra
ORMDL1 Q9P0S3 ZFYVE27 Homo sapiens Q5T4F4
Y2H Prey Pooling
32296183
Intra
ORMDL1 Q9P0S3 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
ORMDL1 Q9P0S3 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
ORMDL1 Q9P0S3 SAR1A Homo sapiens Q9NR31
Y2H Array
32296183
Intra
ORMDL1 Q9P0S3 SAR1A Homo sapiens Q9NR31
Y2H Prey Pooling
32296183
Intra
ORMDL1 Q9P0S3 SLC10A1 Homo sapiens Q14973
Y2H Prey Pooling
32296183
Intra
ORMDL1 Q9P0S3 SLC10A1 Homo sapiens Q14973
Y2H Array
32296183
Intra
ORMDL1 Q9P0S3 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
ORMDL1 Q9P0S3 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
ORMDL1 Q9P0S3 COQ9 Homo sapiens O75208
Y2H Prey Pooling
32296183
Intra
ORMDL1 Q9P0S3 COQ9 Homo sapiens O75208
Y2H Array
32296183
Intra
ORMDL1 Q9P0S3 LEPROTL1 Homo sapiens O95214
Y2H Prey Pooling
32296183
Intra
ORMDL1 Q9P0S3 LEPROTL1 Homo sapiens O95214
Y2H Array
32296183
Intra
ORMDL1 Q9P0S3 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
Intra
ORMDL1 Q9P0S3 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
Intra
ORMDL1 Q9P0S3 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
ORMDL1 Q9P0S3 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
ORMDL1 Q9P0S3 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
ORMDL1 Q9P0S3 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra
ORMDL1 Q9P0S3 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
ORMDL1 Q9P0S3 EBAG9 Homo sapiens O00559
Y2H Prey Pooling
32296183
Intra
ORMDL1 Q9P0S3 EBAG9 Homo sapiens O00559
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09833 ORMDL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown