TMEM35A - transmembrane protein 35A Gene

Also Known as TUF1; NACHO; TUF-1; TMEM35

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 59353

Summary

Enables acetylcholine receptor regulator activity. Involved in chaperone-mediated protein complex assembly and positive regulation of protein localization to cell surface. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Biased expression in brain (RPKM 18.3), prostate (RPKM 12.0) and 12 other tissues.

TMEM35A Products (1)

mRNA Protein Name
NM_021637.3 NP_067650.1 nicotinic acetylcholine receptor chaperone

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables acetylcholine receptor regulator activity IDA
IDA: Inferred from direct assay
26875622 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in chaperone-mediated protein complex assembly IDA
IDA: Inferred from direct assay
26875622 GOA
involved in chaperone-mediated protein complex assembly IMP
IMP: Inferred from mutant phenotype
26875622 GOA
involved in positive regulation of protein localization to cell surface IDA
IDA: Inferred from direct assay
26875622 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
26875622 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM35A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TMEM35A Q53FP2 RTP2 Homo sapiens Q5QGT7
Validated Y2H
32296183
Intra
TMEM35A Q53FP2 ORMDL1 Homo sapiens Q9P0S3
Validated Y2H
32296183
Intra
TMEM35A Q53FP2 VAPA Homo sapiens Q9P0L0
Validated Y2H
32296183
Intra
TMEM35A Q53FP2 CMTM5 Homo sapiens Q96DZ9-2
Validated Y2H
32296183
Intra
TMEM35A Q53FP2 GIMAP1 Homo sapiens Q8WWP7
Validated Y2H
32296183
Intra
TMEM35A Q53FP2 TMEM201 Homo sapiens Q5SNT2-2
Validated Y2H
32296183
Intra
TMEM35A Q53FP2 TMEM42 Homo sapiens Q69YG0
Validated Y2H
32296183
Intra
TMEM35A Q53FP2 LNPEP Homo sapiens Q9UIQ6-2
Validated Y2H
32296183
Intra
TMEM35A Q53FP2 TMEM229B Homo sapiens Q8NBD8
Validated Y2H
32296183
Intra
TMEM35A Q53FP2 FIMP Homo sapiens Q96LL3
Validated Y2H
32296183
Intra
TMEM35A Q53FP2 FIMP Homo sapiens Q96LL3
Y2H Array
32296183
Intra
TMEM35A Q53FP2 FIMP Homo sapiens Q96LL3
Y2H Prey Pooling
32296183
Intra
TMEM35A Q53FP2 TMEM243 Homo sapiens Q9BU79
Validated Y2H
32296183
Intra
TMEM35A Q53FP2 PPGB Homo sapiens Q59EV6
Validated Y2H
32296183
Intra
TMEM35A Q53FP2 TMEM14C Homo sapiens Q9P0S9
Validated Y2H
32296183
Intra
TMEM35A Q53FP2 TMEM106C Homo sapiens Q9BVX2
Validated Y2H
32296183
Intra
TMEM35A Q53FP2 TMEM106C Homo sapiens Q9BVX2
Y2H Prey Pooling
32296183
Intra
TMEM35A Q53FP2 TMEM106C Homo sapiens Q9BVX2
Y2H Array
32296183
Intra
TMEM35A Q53FP2 COX20 Homo sapiens Q5RI15
Validated Y2H
32296183
Intra
TMEM35A Q53FP2 TMEM222 Homo sapiens Q9H0R3
Validated Y2H
32296183
Intra
TMEM35A Q53FP2 FXYD6 Homo sapiens Q9H0Q3
Validated Y2H
32296183
Intra
TMEM35A Q53FP2 TMEM120A Homo sapiens Q9BXJ8
Validated Y2H
32296183
Intra
TMEM35A Q53FP2 RUSF1 Homo sapiens Q96GQ5
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14716 TMEM30A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14719 TMEM38A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14721 TMEM39A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14726 TMEM45A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21264 Tmem45a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27783 Tmem45a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown