FXYD6 - FXYD domain containing ion transport regulator 6 Gene

Homo sapiens

Gene ID: 53826 | Gene type: protein coding

About FXYD6

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:117,836,981-117,877,430 (from NCBI)

This gene has 17 transcripts (splice variants), 152 orthologues and 6 paralogues. Broad expression in brain (RPKM 186.7), ovary (RPKM 91.7) and 16 other tissues.

Summary

This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes phosphohippolin, which likely affects the activity of Na,K-ATPase. Multiple alternatively spliced transcript variants encoding the same protein have been described. Related pseudogenes have been identified on chromosomes 10 and X. Read-through transcripts have been observed between this locus and the downstream sodium/potassium-transporting ATPase subunit gamma (FXYD2, GeneID 486) locus.[provided by RefSeq, Feb 2011]

FXYD6 Products(5)

mRNA	Protein	Name
NM_001164831.3	NP_001158303.1	FXYD domain-containing ion transport regulator 6 precursor
NM_001164832.3	NP_001158304.1	FXYD domain-containing ion transport regulator 6 precursor
NM_001164836.3	NP_001158308.1	FXYD domain-containing ion transport regulator 6 precursor
NM_001164837.3	NP_001158309.1	FXYD domain-containing ion transport regulator 6 precursor
NM_022003.4	NP_071286.1	FXYD domain-containing ion transport regulator 6 precursor

FXYD6 Protein Structure

ATP1G1_PLM_MAT8

0
95 a.a.

Protein Preferred Names

Protein Names

FXYD domain-containing ion transport regulator 6

phosphohippolin

Related Diseases

Diseases

Alias

Hypomagnesemia 2, Renal

Renal Hypomagnesemia 2	HOMG2
Magnesium Wasting, Renal	Autosomal Dominant Primary Hypomagnesemia With Hypocalciuria
Magnesium Loss, Isolated Renal	Isolated Autosomal Dominant Hypomagnesemia
Isolated Renal Magnesium Wasting	Renal Hypomagnesemia Type 2
Hypomagnesemia 2	Dominant Renal Hypomagnesemia
Hypomagnesemia With Hypocalciuria	Isolated Renal Magnesium Loss
Renal Magnesium Wasting	Hypomagnesemia-2, Renal
Renal Hypomagnesemia, Dominant	Hypomagnesemia, Type 2, Renal

Alternating Hemiplegia Of Childhood

Alternating Hemiplegia	Ahc
Alternating Hemiplegia Syndrome	Hemiplegia, Alternating, Of Childhood
Hemiplegia, Crossed

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05170	FXYD6 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FXYD6	RGD	RGD:69315
Mus musculus	FXYD6	MGD	MGI:1890226
Bos taurus	FXYD6	VGNC	VGNC:54871
Canis familiaris	FXYD6	VGNC	VGNC:56011

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