FXYD6 - FXYD domain containing ion transport regulator 6 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 53826

About FXYD6

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:117,836,981-117,877,430 (from NCBI)

This gene has 17 transcripts (splice variants), 152 orthologues and 6 paralogues. Broad expression in brain (RPKM 186.7), ovary (RPKM 91.7) and 16 other tissues.

Summary

This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes phosphohippolin, which likely affects the activity of Na,K-ATPase. Multiple alternatively spliced transcript variants encoding the same protein have been described. Related pseudogenes have been identified on chromosomes 10 and X. Read-through transcripts have been observed between this locus and the downstream sodium/potassium-transporting ATPase subunit gamma (FXYD2, GeneID 486) locus.[provided by RefSeq, Feb 2011]

FXYD6 Products (5)

mRNA Protein Name
NM_001164831.3 NP_001158303.1 FXYD domain-containing ion transport regulator 6 precursor
NM_001164832.3 NP_001158304.1 FXYD domain-containing ion transport regulator 6 precursor
NM_001164836.3 NP_001158308.1 FXYD domain-containing ion transport regulator 6 precursor
NM_001164837.3 NP_001158309.1 FXYD domain-containing ion transport regulator 6 precursor
NM_022003.4 NP_071286.1 FXYD domain-containing ion transport regulator 6 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FXYD6 Protein Structure

ATP1G1_PLM_MAT8

ATP1G1_PLM_MAT8: ATP1G1/PLM/MAT8 family (24 - 72)

  • 0
  • 95 a.a.
Protein Preferred Names Protein Names

FXYD domain-containing ion transport regulator 6

  • phosphohippolin

FXYD6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FXYD6 Q9H0Q3 JAGN1 Homo sapiens Q8N5M9
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 JAGN1 Homo sapiens Q8N5M9
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 PGRMC2 Homo sapiens O15173
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 PGRMC2 Homo sapiens O15173
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 TMEM239 Homo sapiens Q8WW34-2
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 TMEM239 Homo sapiens Q8WW34-2
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 TMEM35A Homo sapiens Q53FP2
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 TMEM35A Homo sapiens Q53FP2
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 TMPPE Homo sapiens Q6ZT21
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 TMPPE Homo sapiens Q6ZT21
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 MFF Homo sapiens Q9GZY8-5
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 MFF Homo sapiens Q9GZY8-5
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 KCNJ6 Homo sapiens P48051
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 KCNJ6 Homo sapiens P48051
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 RHBDL1 Homo sapiens O75783
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 RHBDL1 Homo sapiens O75783
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 CD74 Homo sapiens P04233-2
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 CD74 Homo sapiens P04233-2
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 TMEM72 Homo sapiens A0PK05
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 TMEM72 Homo sapiens A0PK05
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 SVOP Homo sapiens Q8N4V2
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 SVOP Homo sapiens Q8N4V2
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 SLC47A1 Homo sapiens Q96FL8
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 SLC47A1 Homo sapiens Q96FL8
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 SLC39A2 Homo sapiens Q9NP94
Validated Y2H
32296183
Intra
FXYD6 Q9H0Q3 SLC39A2 Homo sapiens Q9NP94
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 SLC39A2 Homo sapiens Q9NP94
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 APCDD1L Homo sapiens Q8NCL9
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 APCDD1L Homo sapiens Q8NCL9
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 TLCD4 Homo sapiens Q96MV1
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 TMEM154 Homo sapiens Q6P9G4
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 TMEM154 Homo sapiens Q6P9G4
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 TM4SF18 Homo sapiens Q96CE8
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 TM4SF18 Homo sapiens Q96CE8
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 SLC35E3 Homo sapiens Q7Z769
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 SLC35E3 Homo sapiens Q7Z769
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 RHCG Homo sapiens Q9UBD6
Validated Y2H
32296183
Intra
FXYD6 Q9H0Q3 RHCG Homo sapiens Q9UBD6
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 RHCG Homo sapiens Q9UBD6
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 ELOVL2 Homo sapiens Q9NXB9
Validated Y2H
32296183
Intra
FXYD6 Q9H0Q3 ELOVL2 Homo sapiens Q9NXB9
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 ELOVL2 Homo sapiens Q9NXB9
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 FPR2 Homo sapiens P25090
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 FPR2 Homo sapiens P25090
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 SLC35C2 Homo sapiens Q9NQQ7-3
Validated Y2H
32296183
Intra
FXYD6 Q9H0Q3 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 LHFPL2 Homo sapiens Q6ZUX7
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 LHFPL2 Homo sapiens Q6ZUX7
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 GPR42 Homo sapiens O15529
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 RNASEK Homo sapiens Q6P5S7
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 RNASEK Homo sapiens Q6P5S7
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 ELOVL4 Homo sapiens Q9GZR5
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 ELOVL4 Homo sapiens Q9GZR5
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 TMEM86B Homo sapiens Q8N661
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 TMEM86B Homo sapiens Q8N661
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 APH1A Homo sapiens Q96BI3
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 APH1A Homo sapiens Q96BI3
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 CERS4 Homo sapiens Q9HA82
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 CERS4 Homo sapiens Q9HA82
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 CERS4 Homo sapiens Q9HA82
Validated Y2H
32296183
Intra
FXYD6 Q9H0Q3 OCIAD1 Homo sapiens Q9NX40
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 OCIAD1 Homo sapiens Q9NX40
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 OCIAD1 Homo sapiens Q9NX40
Validated Y2H
32296183
Intra
FXYD6 Q9H0Q3 LHFPL5 Homo sapiens Q8TAF8
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 LHFPL5 Homo sapiens Q8TAF8
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 CLEC10A Homo sapiens Q8IUN9
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 CLEC10A Homo sapiens Q8IUN9
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 SLC16A7 Homo sapiens O60669
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 SLC16A7 Homo sapiens O60669
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 SLC10A1 Homo sapiens Q14973
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 SLC10A1 Homo sapiens Q14973
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 PEX12 Homo sapiens O00623
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 PEX12 Homo sapiens O00623
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 MMGT1 Homo sapiens Q8N4V1
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 MMGT1 Homo sapiens Q8N4V1
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
25416956
Intra
FXYD6 Q9H0Q3 CREB3L1 Homo sapiens Q96BA8
Y2H Array
25416956
Intra
FXYD6 Q9H0Q3 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
25416956
Intra
FXYD6 Q9H0Q3 MGST3 Homo sapiens O14880
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 MGST3 Homo sapiens O14880
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 CLDN7 Homo sapiens O95471
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 CLDN7 Homo sapiens O95471
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
FXYD6 Q9H0Q3 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 DERL2 Homo sapiens Q9GZP9
Y2H Prey Pooling
32296183
Intra
FXYD6 Q9H0Q3 SLC30A2 Homo sapiens Q9BRI3
Y2H Array
32296183
Intra
FXYD6 Q9H0Q3 SLC30A2 Homo sapiens Q9BRI3
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypomagnesemia 2, Renal

  • Renal Hypomagnesemia 2

  • HOMG2

  • Magnesium Wasting, Renal

  • Autosomal Dominant Primary Hypomagnesemia With Hypocalciuria

  • Magnesium Loss, Isolated Renal

  • Isolated Autosomal Dominant Hypomagnesemia

  • Isolated Renal Magnesium Wasting

  • Renal Hypomagnesemia Type 2

  • Hypomagnesemia 2

  • Dominant Renal Hypomagnesemia

  • Hypomagnesemia With Hypocalciuria

  • Isolated Renal Magnesium Loss

  • Renal Magnesium Wasting

  • Hypomagnesemia-2, Renal

  • Renal Hypomagnesemia, Dominant

  • Hypomagnesemia, Type 2, Renal
Alternating Hemiplegia Of Childhood

  • Alternating Hemiplegia

  • Ahc

  • Alternating Hemiplegia Syndrome

  • Hemiplegia, Alternating, Of Childhood

  • Hemiplegia, Crossed
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05170 FXYD6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus FXYD6 RGD RGD:69315
Mus musculus FXYD6 MGD MGI:1890226
Bos taurus FXYD6 VGNC VGNC:54871
Canis familiaris FXYD6 VGNC VGNC:56011
Others FXYD6 NCBI