SLC47A1 - solute carrier family 47 member 1 Gene

Also Known as MATE1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55244

About SLC47A1

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:19,533,854-19,579,034 (from NCBI)

This gene has 14 transcripts (splice variants), 280 orthologues and 1 paralogue. Biased expression in adrenal (RPKM 59.0), kidney (RPKM 50.0) and 6 other tissues.

Summary

This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown function. [provided by RefSeq, Jul 2008]

SLC47A1 Products (1)

mRNA	Protein	Name
NM_018242.3	NP_060712.2	multidrug and toxin extrusion protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables L-amino acid transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	23864433	GOA
enables L-arginine transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	23864433	GOA
enables antiporter activity	IDA IDA: Inferred from direct assay	16330770	GOA
enables organic cation transmembrane transporter activity	IDA IDA: Inferred from direct assay	16330770	GOA
enables polyspecific organic cation:proton antiporter activity	IDA IDA: Inferred from direct assay	16330770	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables putrescine transmembrane transporter activity	IDA IDA: Inferred from direct assay	21128598	GOA
enables thiamine transmembrane transporter activity	IDA IDA: Inferred from direct assay	24961373	GOA
enables xenobiotic transmembrane transporter activity	IDA IDA: Inferred from direct assay	16330770	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in L-alpha-amino acid transmembrane transport	IMP IMP: Inferred from mutant phenotype	23864433	GOA
involved in L-arginine import across plasma membrane	IMP IMP: Inferred from mutant phenotype	23864433	GOA
involved in amino acid import across plasma membrane	IMP IMP: Inferred from mutant phenotype	23864433	GOA
involved in organic cation transport	IDA IDA: Inferred from direct assay	16330770	GOA
involved in putrescine transport	IDA IDA: Inferred from direct assay	21128598	GOA
involved in xenobiotic detoxification by transmembrane export across the plasma membrane	IDA IDA: Inferred from direct assay	16330770	GOA
involved in xenobiotic transport	IMP IMP: Inferred from mutant phenotype	23864433	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	16330770	GOA
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	31791063	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	28112518	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC47A1 Protein Structure

MatE

0
100
200
300
400
500
570 a.a.

Protein Preferred Names	Protein Names
multidrug and toxin extrusion protein 1	MATE-1

SLC47A1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLC47A1	Q96FL8	FXYD6	Homo sapiens	Q9H0Q3	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Smith-Magenis Syndrome	SMS Chromosome 17p11.2 Deletion Syndrome 17p11.2 Microdeletion Syndrome 17p11.2 Monosomy Chromosome 17p Deletion Syndrome Del(17) P11.2 17p- Syndrome Deletion 17p Syndrome Partial Monosomy 17p

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13263	SLC47A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20648	Slc47a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27159	Slc47a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLC47A1	RGD	RGD:1311123
Canis familiaris	SLC47A1	VGNC	VGNC:49819
Bos taurus	SLC47A1	VGNC	VGNC:34887
Felis catus	SLC47A1	VGNC	VGNC:99453
Macaca mulatta	SLC47A1	VGNC	VGNC:77774