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FPR2 - formyl peptide receptor 2 Gene

Also Known as ALX; ALXR; HM63; FMLPX; FPR2A; FPRH1; FPRH2; FPRL1; LXA4R; FMLP-R-II

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2358

About FPR2

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,761,180-51,770,531 (from NCBI)

This gene has 6 transcripts (splice variants), 140 orthologues and 8 paralogues. Biased expression in appendix (RPKM 23.5), spleen (RPKM 4.6) and 5 other tissues.

Summary

Enables amyloid-beta binding activity; scavenger receptor binding activity; and signaling receptor activity. Involved in several processes, including cellular response to amyloid-beta; positive regulation of monocyte chemotaxis; and regulation of defense response. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

FPR2 Products (2)

mRNA	Protein	Name
NM_001005738.2	NP_001005738.1	N-formyl peptide receptor 2
NM_001462.3	NP_001453.1	N-formyl peptide receptor 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables amyloid-beta binding	IPI IPI: Inferred from physical interaction	11316806	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15465011	GOA
enables scavenger receptor binding	IPI IPI: Inferred from physical interaction	20141570	GOA
enables signaling receptor activity	IDA IDA: Inferred from direct assay	25505240	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor signaling pathway	IGI IGI: Inferred from genetic interaction	11160457	GOA
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IGI IGI: Inferred from genetic interaction	20141570	GOA
involved in calcium-mediated signaling	IGI IGI: Inferred from genetic interaction	11160457	GOA
involved in cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	25505240	GOA
involved in cellular response to amyloid-beta	IDA IDA: Inferred from direct assay	11316806	GOA
involved in defense response to bacterium	IDA IDA: Inferred from direct assay	25505240	GOA
involved in immune response-regulating cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	25505240	GOA
involved in negative regulation of inflammatory response	IDA IDA: Inferred from direct assay	25505240	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IGI IGI: Inferred from genetic interaction	20141570	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	20141570	GOA
involved in positive regulation of innate immune response	IDA IDA: Inferred from direct assay	25505240	GOA
involved in positive regulation of monocyte chemotaxis	IGI IGI: Inferred from genetic interaction	11160457	GOA
involved in positive regulation of phagocytosis	IDA IDA: Inferred from direct assay	25505240	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11689470	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	11689470	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FPR2 Protein Structure

7tm_1

0
100
200
300
351 a.a.

Protein Preferred Names	Protein Names
N-formyl peptide receptor 2	FMLP-R-I

FPR2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FPR2	P25090	LRRC25	Homo sapiens	Q8N386	Y2H Prey Pooling	32296183
Intra	FPR2	P25090	LRRC25	Homo sapiens	Q8N386	Validated Y2H	32296183
Intra	FPR2	P25090	LRRC25	Homo sapiens	Q8N386	Y2H Array	32296183
Intra	FPR2	P25090	SSMEM1	Homo sapiens	Q8WWF3	Validated Y2H	32296183
Intra	FPR2	P25090	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	FPR2	P25090	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	FPR2	P25090	FXYD6	Homo sapiens	Q9H0Q3	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

FPR2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89830	FPR2 Antibody (YA9174)	WB, IP, FC	human

Related Diseases

Diseases	Alias
Diamond-Blackfan Anemia 2	DBA2 Anemia, Diamond-Blackfan, 2 Anemia Diamond-Blackfan 2
Prion Disease	Spongiform Encephalopathy Transmissible Spongiform Encephalopathies Prion Diseases Prion Disease Pathway Transmissible Spongiform Encephalopathy Prion Induced Disorder Prion Protein Disease Inherited Human Transmissible Spongiform Encephalopathies Prion Protein Diseases Prion-Associated Disorders Prion-Induced Disorders Transmissible Dementias Tses Human Prion Disease Tse Encephalopathy, Transmissible Spongiform Prion Disease, Susceptibility To Spongiform Encephalopathies Human Transmissible Spongiform Encephalopathies, Inherited
Severe Congenital Neutropenia 2	Scn2
Anaerobic Meningitis
Bacterial Infectious Disease	Bacterial Infections Bacterial Infection Nos Disease Caused By Bacteria Bacterial Disease Or Disorder
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-131180	BMS-986235		99.84%	Phase 1
HY-124071	ACT-389949		98.42%	Phase 1

Pre-clinical Phase

Bioactive Molecules (21)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1120	WKYMVm		99.74%	Unkown
HY-103286	PD176252	Antagonist	99.38%	Unkown
HY-19574	FPR Agonist 43		99.79%	Unkown
HY-116216	PD 168368	Antagonist	≥99.0%	Unkown
HY-P1744	N-Formyl-Met-Leu-Phe-Lys		99.83%	Unkown
HY-P1117	MMK1		99.71%	Unkown
HY-W668775	Quin-C7	Antagonist	99.76%	Unkown
HY-155335	FPR2 agonist 3	Agonist	99.39%	Unkown
HY-144604	FPR2 agonist 2	Agonist	98.51%	Unkown
HY-110246	Quin C1	Agonist	98.47%	Unkown
HY-P1120A	WKYMVm TFA		/	Unkown
HY-159583	FPR2 agonist 4	Agonist	/	Unkown
HY-178144	FPR2 agonist 5		/	Unkown
HY-181822	BMS-986331		/	Unkown
HY-183952	FPR2/ALXR agonist-1	Agonist	/	Unkown
HY-184654	MR-39		/	Unkown
HY-P10432	SHAAGtide	Activator	/	Unkown
HY-P1117A	MMK1 TFA		/	Unkown
HY-RS05086	FPR2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16582	Fpr2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23016	Fpr2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FPR2	MGD	MGI:1278319
Rattus norvegicus	FPR2	RGD	RGD:1584013
Macaca mulatta	FPR2	VGNC	VGNC:109506