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BMS-986235 (Synonyms: LAR-1219)

Cat. No.: HY-131180 Purity: 99.77%
Handling Instructions

BMS-986235 (LAR-1219) is a selective, orally active formyl peptide receptor 2 (FPR2) agonist, with EC50s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively. BMS-986235 has potential for the prevention of heart failure.

For research use only. We do not sell to patients.

BMS-986235 Chemical Structure

BMS-986235 Chemical Structure

CAS No. : 2253947-47-4

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Based on 1 publication(s) in Google Scholar

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Description

BMS-986235 (LAR-1219) is a selective, orally active formyl peptide receptor 2 (FPR2) agonist, with EC50s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively. BMS-986235 has potential for the prevention of heart failure[1].

IC50 & Target

EC50: 0.41 nM (human FPR2), 3.4 nM (mouse FPR2), 2800 nM (human FPR1)[1]

In Vitro

BMS-986235 (LAR-1219) inhibits neutrophil chemotaxis and stimulats macrophage phagocytosis, key end points to promote resolution of inflammation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BMS-986235 (LAR-1219) (0.3 mg/kg; p.o.; daily for 24 days) can attenuate left ventricle and global cardiac remodeling after left anterior descending (LAD) in mice[1].
BMS-986235 (1 mg/kg; p.o.) treatment shows the Cmax, T1/2, AUC0-inf, and bioavailability (BA) values of 160 nmol/L, 0.68 hours,120 nmol/L•h, and 24%, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice[1]
Dosage: 0.3 mg/kg
Administration: P.o.; daily for 24 days
Result: Left ventricle (LV) chamber remodeling is attenuated after myocardial infarction (MI). Reduced infarct length by 39% relative to vehicle.
Animal Model: Male mice (BALB/cCrSlc)[1]
Dosage: 1 mg/kg
Administration: P.o. (Pharmacokinetic Analysis)
Result: The Cmax, T1/2, AUC0-inf, and bioavailability (BA) values were 160 nmol/L, 0.68 hours, 120 nmol/L•h, and 24%, respectively.
Molecular Weight

361.34

Formula

C₁₈H₁₇F₂N₃O₃

CAS No.

2253947-47-4

SMILES

O=C(NC1=CC=CC=C1)N[[email protected]@H]2C(NC[[email protected]]2C3=C(F)C=C(OC)C=C3F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References
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Keywords:

BMS-986235LAR-1219BMS986235BMS 986235LAR1219LAR 1219OthersheartfailureneutrophilchemotaxismacrophagephagocytosisinflammationInhibitorinhibitorinhibit

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BMS-986235
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