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FPR Agonist 43 

Cat. No.: HY-19574 Purity: 97.12%
Handling Instructions

FPR Agonist 43 (compound 43) is a dual formyl peptide receptor 1 (FPR1) and formyl peptide receptor 2 (FPR2)/ALX agonist.

For research use only. We do not sell to patients.

FPR Agonist 43 Chemical Structure

FPR Agonist 43 Chemical Structure

CAS No. : 903895-98-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 190 In-stock
Estimated Time of Arrival: December 31
50 mg USD 760 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

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Based on 1 publication(s) in Google Scholar

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Description

FPR Agonist 43 (compound 43) is a dual formyl peptide receptor 1 (FPR1) and formyl peptide receptor 2 (FPR2)/ALX agonist[1][2].

IC50 & Target

FPR1, FPR2/ALX[1]

In Vitro

FPR Agonist 43 (10-5-107 nM) is actively potent in the cAMP assay in FPR2/ALX over-expressing CHO cells[1].
FPR Agonist 43 is also active in the GTPγ binding assay (IC50=207±51 nM)[1].
FPR1 is the preferred receptor for FPR Agonist 43 in in both human neutrophils and possibly also in mouse cells[2].

Cell Viability Assay[1]

Cell Line: Chinese hamster ovary (CHO) over-expressing human FPR2/ALX receptors
Concentration: 10-5, 10-3, 0.1, 10, 1000, 105, 107 nM
Incubation Time:
Result: Actively potent in the cAMP assay in FPR2/ALX over-expressing CHO cells (IC50 =11.6±1.9 nM).
Molecular Weight

384.86

Formula

C₂₀H₂₁ClN₄O₂

CAS No.

903895-98-7

SMILES

O=C(NC1=C(C(C)C)N(C)N(C2=CC=CC=C2)C1=O)NC3=CC=C(Cl)C=C3

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (324.79 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5983 mL 12.9917 mL 25.9835 mL
5 mM 0.5197 mL 2.5983 mL 5.1967 mL
10 mM 0.2598 mL 1.2992 mL 2.5983 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.40 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
FPR Agonist 43
Cat. No.:
HY-19574
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