New 'chemical probes' to examine the role of the hFPRL1 (or ALXR) receptor in inflammation

  • Bioorg Med Chem Lett. 2007 Dec 1;17(23):6633-7. doi: 10.1016/j.bmcl.2007.09.043.
Mike Frohn  1 ,  Han Xu ,  Xiaoming Zou ,  Catherine Chang ,  Michele McElvaine ,  Matthew H Plant ,  Min Wong ,  Philip Tagari ,  Randall Hungate ,  Roland W Bürli
Affiliations
  • 1. Chemistry Research and Discovery, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. [email protected]
PMID: 17920884 DOI: 10.1016/j.bmcl.2007.09.043
Abstract

We report the development of the novel N-substituted benzimidazole 11 as a potent and selective human formyl peptide receptor-like 1 (hFPRL1) agonist. This compound and its less active enantiomer 12 were identified as useful tools for studying receptor function in vitro.