Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents

  • Bioorg Med Chem Lett. 2006 Jul 15;16(14):3713-8. doi: 10.1016/j.bmcl.2006.04.068.
Roland W Bürli  1 ,  Han Xu ,  Xiaoming Zou ,  Kristine Muller ,  Jennifer Golden ,  Mike Frohn ,  Matthew Adlam ,  Matthew H Plant ,  Min Wong ,  Michele McElvain ,  Kelly Regal ,  Vellarkad N Viswanadhan ,  Philip Tagari ,  Randall Hungate
Affiliations
  • 1. Chemistry Research and Discovery, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. [email protected]
PMID: 16697190 DOI: 10.1016/j.bmcl.2006.04.068
Abstract

We report the discovery of potent agonists for the human formyl-peptide-like 1 receptor (hFPRL1). These compounds did not act at a closely related receptor denoted human formyl peptide receptor (hFPR) up to 10 microM concentration. Recent studies have indicated that agonizing this receptor may promote resolution of inflammation. In an exploratory study, a novel hFPRL1 agonist showed efficacy in a mouse ear inflammation model following oral administration.

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