MMK1

Cat. No.: HY-P1117: FAQs
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MMK1 is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC₅₀s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 is a potent chemotactic and calcium-mobilizing agonist. MMK1 potently activates phagocytic leukocytes and enhances Pertussis Toxin (HY-112779)-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 exerts anxiolytic-like activity.

For research use only. We do not sell to patients.

MMK1 Chemical Structure

CAS No. : 271246-66-3

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Purity & Documentation
References
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Description

IC₅₀ & Target^[1]^[2]

Calcium Channel

In Vitro

MMK-1 induces calcium mobilization in human FPRL1-transfected HEK 293 (FPRL1/293) cells with an EC₅₀ of 2 nM^[1].
MMK1 (1 μM; for 4 h) induces selective migration of FPR2-expressing RBL-2H3 cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MMK1 (10-1000 pmol; ICV; 20 min before the test) exerts an aniolytic-exerted an anxiolytic-like activity at a dose of 100 pmol/mouse^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Four-week-old male ddY mice^[4]
Dosage:	10, 100, 1000 pmol/mouse
Administration:	ICV; 20 min before the test
Result:	Exerted an aniolytic-exerted an anxiolytic-like activity at a dose of 100 pmol/mouse.

Molecular Weight

1610.96

Formula

C₇₅H₁₂₃N₁₉O₁₈S

CAS No.

271246-66-3

Sequence

Leu-Glu-Ser-Ile-Phe-Arg-Ser-Leu-Leu-Phe-Arg-Val-Met

Sequence Shortening

LESIFRSLLFRVM

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. C Klein, et al. Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeast. Nat Biotechnol. 1998 Dec;16(13):1334-7. [Content Brief]

[2]. Phuong Doan, et al. Alkylaminophenol and GPR17 Agonist for Glioblastoma Therapy: A Combinational Approach for Enhanced Cell Death Activity. Cells. 2021 Aug 3;10(8):1975. [Content Brief]

[3]. Yoo Jung Park, et al. A novel antimicrobial peptide acting via formyl peptide receptor 2 shows therapeutic effects against rheumatoid arthritis. Sci Rep. 2018 Oct 2;8(1):14664. [Content Brief]

[4]. Hui Zhao, et al. Rubimetide, humanin, and MMK1 exert anxiolytic-like activities via the formyl peptide receptor 2 in mice followed by the successive activation of DP1, A2A, and GABAA receptors. Peptides. 2016 Sep;83:16-20. [Content Brief]

MMK1 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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