1. GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel
  2. Formyl Peptide Receptor (FPR) Calcium Channel
  3. MMK1 TFA

MMK1 TFA is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC50s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 TFA is a potent chemotactic and calcium-mobilizing agonist. MMK1 TFA potently activates phagocytic leukocytes and enhances Pertussis Toxin (HY-112779)-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 TFA exerts anxiolytic-like activity.

For research use only. We do not sell to patients.

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MMK1 TFA Chemical Structure

MMK1 TFA Chemical Structure

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Description

MMK1 TFA is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC50s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 TFA is a potent chemotactic and calcium-mobilizing agonist. MMK1 TFA potently activates phagocytic leukocytes and enhances Pertussis Toxin (HY-112779)-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 TFA exerts anxiolytic-like activity[1][2][3][4].

IC50 & Target[1][2]

Calcium Channel

 

In Vitro

MMK-1 TFA induces calcium mobilization in human FPRL1-transfected HEK 293 (FPRL1/293) cells with an EC50 of 2 nM[1].
MMK1 (1 μM; for 4 h) TFA induces selective migration of FPR2-expressing RBL-2H3 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MMK1 (10-1000 pmol; ICV; 20 min before the test) TFA exerts an aniolytic-exerted an anxiolytic-like activity at a dose of 100 pmol/mouse[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Four-week-old male ddY mice[4]
Dosage: 10, 100, 1000 pmol/mouse
Administration: ICV; 20 min before the test
Result: Exerted an aniolytic-exerted an anxiolytic-like activity at a dose of 100 pmol/mouse.
Molecular Weight

1610.96 (free acid)

Formula

C75H123N19O18S.xC2HF3O2

Sequence

Leu-Glu-Ser-Ile-Phe-Arg-Ser-Leu-Leu-Phe-Arg-Val-Met

Sequence Shortening

LESIFRSLLFRVM

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
MMK1 TFA
Cat. No.:
HY-P1117A
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