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ACT-389949 

Cat. No.: HY-124071
Handling Instructions

ACT-389949 is a first-in-class, potent and selective and agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalization into monocytes. ACT-389949 has potential for the treatment of inflammatory disorders.

For research use only. We do not sell to patients.

ACT-389949 Chemical Structure

ACT-389949 Chemical Structure

CAS No. : 1258417-54-7

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Description

ACT-389949 is a first-in-class, potent and selective and agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalization into monocytes. ACT-389949 has potential for the treatment of inflammatory disorders[1][2].

IC50 & Target

(FPR2)/(ALX)[1]

In Vivo

ACT-389949 has well tolerated. Maximum concentrations are reached around 2 hours after dosing, with a mean terminal half-life of 29.3 hours[1].
Administration of ACT-389949 results in a dose-dependent, long-lasting internalization of FPR2/ALX into leukocytes[1].

Clinical Trial
Molecular Weight

428.39

Formula

C₂₀H₁₈F₂N₆O₃

CAS No.

1258417-54-7

SMILES

O=C(C1=C(C2=CC=CC(C)=C2)OC(C)=N1)NC3=NN(CC4=NC(C(F)(F)C)=CO4)N=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

ACT-389949ACT389949ACT 389949OthersInhibitorinhibitorinhibit

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