FPR2 agonist 5
FPR2 agonist 5 is a selective Formyl Peptide Receptor 2 (FPR2) agonist. FPR2 agonist 5 induces Ca2+ mobilization in FPR2-HL60 transfected cells with an EC50 of 1.2 μM and causes FPR2 desensitization with an IC50 of 0.32 μM. FPR2 agonist 5 exerts neuroprotective effects by mitigating LDH release, NO production, IL-1β, IL-6, IL-33, and IL-10 levels in LPS (HY-D1056)-induced mouse primary microglial cells. FPR2 agonist 5 can be used for the study of neuroinflammatory-related diseases.
For research use only. We do not sell to patients.
- Formula: C26H20FN5O2
- Molecular Weight:453.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
FPR2 agonist 5 (Compound (S)-9a) (1 μM, 1 h pretreatment) mitigates LDH release and NO production in LPS-induced mouse primary microglial cells[1].
FPR2 agonist 5 (1 μM, 1 h pretreatment) decreases LPS-induced increases in IL-1β, IL-6, IL-33, and IL-10 levels in mouse primary microglial cells[1].
FPR2 agonist 5 induces Ca2+ mobilization with an EC50 of 1.2 μM and causes FPR2 desensitization with an IC50 of 0.32 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Mouse primary microglial cells
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Concentration:1 μM
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Incubation Time:1 h pretreatment
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Result:Decreased LPS-induced increases in IL-1β, IL-6, IL-33, and IL-10 levels in mouse primary microglial cells.
Chemical Information
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Molecular Weight 453.47
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Formula C26H20FN5O2
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SMILES
N#CC1=CC=C(C[C@H](NC2=NN=C(C3=CC=C(F)C=C3)O2)C(N4CCC5=C4C=CC=C5)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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