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  4. FPR2 agonist 2

FPR2 agonist 2 is a potent and permeates the blood−brain barrier FPR2 agonist with an EC50 of 0.13 µM, 1.1 µM for FPR2 and FPR1, respectively. FPR2 agonist 2 inhibits the production of pro-inflammatory cytokines, counterbalances the changes in mitochondrial function, and inhibits caspase-3 activity.

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FPR2 agonist 2 Chemical Structure

FPR2 agonist 2 Chemical Structure

CAS No. : 2829263-20-7

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FPR2 agonist 2 Related Antibodies

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Description

FPR2 agonist 2 is a potent and permeates the blood−brain barrier FPR2 agonist with an EC50 of 0.13 µM, 1.1 µM for FPR2 and FPR1, respectively. FPR2 agonist 2 inhibits the production of pro-inflammatory cytokines, counterbalances the changes in mitochondrial function, and inhibits caspase-3 activity[1].

IC50 & Target

EC50: 0.13 µM (FPR2); 1.1 µM (FPR1)[1]
In Vitro

FPR2 agonist 2 (compound (S)-11l) (1-100 µM; 48 h) exhibits low cytotoxicity with an EC50 value of 20.8 µM in N9 cells[1].
FPR2 agonist 2 (FPR1/FPR2 HL60 cells) shows agonist activity with EC50s of 0.13 µM, 1.1 µM (IC50s of 0.085 µM, Not determined) for FPR2 and FPR1, respectively[1].
FPR2 agonist 2 (0.1 µM) effectively blocks LPS-induced cell death and NO production and effectively suppresses the effect of LPS stimulation[1].
FPR2 agonist 2 (0.1 µM) counterbalances the changes in mitochondrial function, and inhibits caspase-3 activity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FPR2 agonist 2 Related Antibodies

Cell Viability Assay[1]

Cell Line: N9 cells
Concentration: 1-100 µM
Incubation Time: 48 h
Result: Exhibited low cytotoxicity with an EC50 value of 20.8 µM in N9 cells.
In Vivo

FPR2 agonist 2 (1 mg/kg for i.v.; 10 mg/kg for i.p.) shows the ability to permeate the blood−brain barrier and to accumulate in the brain[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 25-30 g, male CD-1 mice[1]
Dosage:
Administration: 1 mg/kg for i.v.; 10 mg/kg for i.p. (dissolved in 5% DMSO, 10% solutol HS 15, and 85% sterile water)
Result: Showed the ability to permeate the blood−brain barrier and to accumulate in the brain.
Molecular Weight

446.45

Formula

C25H20F2N4O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC1=CC=C(C=C1)NC(N[C@H](C(N2CCC3=C2C=CC(F)=C3)=O)CC4=CC=C(C=C4)C#N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (111.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2399 mL 11.1995 mL 22.3989 mL
5 mM 0.4480 mL 2.2399 mL 4.4798 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2399 mL 11.1995 mL 22.3989 mL 55.9973 mL
5 mM 0.4480 mL 2.2399 mL 4.4798 mL 11.1995 mL
10 mM 0.2240 mL 1.1199 mL 2.2399 mL 5.5997 mL
15 mM 0.1493 mL 0.7466 mL 1.4933 mL 3.7332 mL
20 mM 0.1120 mL 0.5600 mL 1.1199 mL 2.7999 mL
25 mM 0.0896 mL 0.4480 mL 0.8960 mL 2.2399 mL
30 mM 0.0747 mL 0.3733 mL 0.7466 mL 1.8666 mL
40 mM 0.0560 mL 0.2800 mL 0.5600 mL 1.3999 mL
50 mM 0.0448 mL 0.2240 mL 0.4480 mL 1.1199 mL
60 mM 0.0373 mL 0.1867 mL 0.3733 mL 0.9333 mL
80 mM 0.0280 mL 0.1400 mL 0.2800 mL 0.7000 mL
100 mM 0.0224 mL 0.1120 mL 0.2240 mL 0.5600 mL
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FPR2 agonist 2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FPR2 agonist 22829263-20-7Othersblood?brain barrierCentral Nervous System DisordersLPSpro-inflammatorymitochondrialcaspase-3Inhibitorinhibitorinhibit

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