FPR2 agonist 2
Based on 1 Customer Validation
FPR2 agonist 2 is a potent and CNS-penetrant FPR2 agonist with an EC50 of 0.13 μM, 1.1 μM for FPR2 and FPR1, respectively. FPR2 agonist 2 inhibits the production of pro-inflammatory cytokines, counterbalances the changes in mitochondrial function, and inhibits caspase-3 activity.
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- 純度: 98.51%
- CAS 番号: 2829263-20-7
- 分子式: C25H20F2N4O2
- 分子量:446.45
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
EC50: 0.13 μM (FPR2); 1.1 μM (FPR1)[1]
FPR2 agonist 2 (compound (S)-11l) (1-100 μM; 48 h) exhibits low cytotoxicity with an EC50 value of 20.8 μM in N9 cells[1].
FPR2 agonist 2 (FPR1/FPR2 HL60 cells) shows agonist activity with EC50s of 0.13 μM, 1.1 μM (IC50s of 0.085 μM, Not determined) for FPR2 and FPR1, respectively[1].
FPR2 agonist 2 (0.1 μM) effectively blocks LPS-induced cell death and NO production and effectively suppresses the effect of LPS stimulation[1].
FPR2 agonist 2 (0.1 μM) counterbalances the changes in mitochondrial function, and inhibits caspase-3 activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:N9 cells
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Concentration:1-100 µM
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Incubation Time:48 h
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Result:Exhibited low cytotoxicity with an EC50 value of 20.8 µM in N9 cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:25-30 g, male CD-1 mice[1]
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Dosage:
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Administration:1 mg/kg for i.v.; 10 mg/kg for i.p. (dissolved in 5% DMSO, 10% solutol HS 15, and 85% sterile water)
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Result:Showed the ability to permeate the blood−brain barrier and to accumulate in the brain.
化学情報
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CAS 番号 2829263-20-7
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性状 Solid
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分子量 446.45
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分子式 C25H20F2N4O2
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Color White to off-white
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SMILES
FC1=CC=C(C=C1)NC(N[C@H](C(N2CCC3=C2C=CC(F)=C3)=O)CC4=CC=C(C=C4)C#N)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 50 mg/mL (111.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2399 mL | 11.1995 mL | 22.3989 mL | 55.9973 mL |
| 5 mM | 0.4480 mL | 2.2399 mL | 4.4798 mL | 11.1995 mL | |
| 10 mM | 0.2240 mL | 1.1199 mL | 2.2399 mL | 5.5997 mL | |
| 15 mM | 0.1493 mL | 0.7466 mL | 1.4933 mL | 3.7332 mL | |
| 20 mM | 0.1120 mL | 0.5600 mL | 1.1199 mL | 2.7999 mL | |
| 25 mM | 0.0896 mL | 0.4480 mL | 0.8960 mL | 2.2399 mL | |
| 30 mM | 0.0747 mL | 0.3733 mL | 0.7466 mL | 1.8666 mL | |
| 40 mM | 0.0560 mL | 0.2800 mL | 0.5600 mL | 1.3999 mL | |
| 50 mM | 0.0448 mL | 0.2240 mL | 0.4480 mL | 1.1199 mL | |
| 60 mM | 0.0373 mL | 0.1867 mL | 0.3733 mL | 0.9333 mL | |
| 80 mM | 0.0280 mL | 0.1400 mL | 0.2800 mL | 0.7000 mL | |
| 100 mM | 0.0224 mL | 0.1120 mL | 0.2240 mL | 0.5600 mL |
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