LHFPL2 - LHFPL tetraspan subfamily member 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10184

About LHFPL2

Cytogenetic location: 5q14.1 Genomic coordinates (GRCh38): 5:78,485,230-78,648,772 (from NCBI)

This gene has 8 transcripts (splice variants), 215 orthologues and 6 paralogues. Ubiquitous expression in gall bladder (RPKM 15.4), urinary bladder (RPKM 12.9) and 25 other tissues.

Summary

This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Mutations in one LHFP-like gene result in deafness in humans and mice, and a second LHFP-like gene is fused to a high-mobility group gene in a translocation-associated lipoma. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

LHFPL2 Products (1)

mRNA Protein Name
NM_005779.3 NP_005770.1 LHFPL tetraspan subfamily member 2 protein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LHFPL2 Protein Structure

L_HMGIC_fpl

L_HMGIC_fpl: Lipoma HMGIC fusion partner-like protein (9 - 204)

  • 0
  • 100
  • 200
  • 228 a.a.
Protein Preferred Names Protein Names

LHFPL tetraspan subfamily member 2 protein

  • LHFP-like protein 2

LHFPL2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LHFPL2 Q6ZUX7 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
LHFPL2 Q6ZUX7 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
LHFPL2 Q6ZUX7 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra
LHFPL2 Q6ZUX7 GJB1 Homo sapiens P08034
Y2H Array
32296183
Intra
LHFPL2 Q6ZUX7 GJB1 Homo sapiens P08034
Y2H Prey Pooling
32296183
Intra
LHFPL2 Q6ZUX7 TMEM147 Homo sapiens Q9BVK8
Validated Y2H
32296183
Intra
LHFPL2 Q6ZUX7 FXYD6 Homo sapiens Q9H0Q3
Validated Y2H
32296183
Intra
LHFPL2 Q6ZUX7 GJA5 Homo sapiens P36382
Y2H Prey Pooling
32296183
Intra
LHFPL2 Q6ZUX7 GJA5 Homo sapiens P36382
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07626 LHFPL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus LHFPL2 VGNC VGNC:68043
Bos taurus LHFPL2 VGNC VGNC:30865
Canis familiaris LHFPL2 VGNC VGNC:42658
Rattus norvegicus LHFPL2 RGD RGD:1309869
Mus musculus LHFPL2 MGD MGI:2145236
Macaca mulatta LHFPL2 VGNC VGNC:74261
Others LHFPL2 NCBI