SLC39A2 - solute carrier family 39 member 2 Gene

Also Known as 6A1; ZIP2; ETI-1; ZIP-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29986

About SLC39A2

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:20,999,293-21,001,871 (from NCBI)

This gene has 3 transcripts (splice variants), 121 orthologues and 2 paralogues. Biased expression in skin (RPKM 12.0), esophagus (RPKM 8.3) and 3 other tissues.

Summary

This gene encodes a member of the ZIP family of metal ion transporters. The encoded protein functions as a zinc transporter. Mutations in this gene may be associated with susceptibility to carotid artery disease. Multiple transcript variants have been described. [provided by RefSeq, Mar 2010]

SLC39A2 Products (2)

mRNA Protein Name
NM_001256588.2 NP_001243517.1 zinc transporter ZIP2 isoform b
NM_014579.4 NP_055394.2 zinc transporter ZIP2 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables metal ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
29791142 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables zinc ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
29791142 GOA
enables zinc ion transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
20148757 GOA
Biological Process GO Annotation Evidence References Source
involved in cadmium ion transmembrane transport IDA
IDA: Inferred from direct assay
29791142 GOA
involved in zinc ion transmembrane transport IDA
IDA: Inferred from direct assay
29791142 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
20148757 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC39A2 Protein Structure

Zip

Zip: ZIP Zinc transporter (6 - 306)

  • 0
  • 100
  • 200
  • 309 a.a.
Protein Preferred Names Protein Names

zinc transporter ZIP2

  • ZRT/IRT-like protein 2

SLC39A2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SLC39A2 Q9NP94 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
Intra
SLC39A2 Q9NP94 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
Intra
SLC39A2 Q9NP94 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
SLC39A2 Q9NP94 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
SLC39A2 Q9NP94 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
SLC39A2 Q9NP94 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
SLC39A2 Q9NP94 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
SLC39A2 Q9NP94 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
SLC39A2 Q9NP94 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra
SLC39A2 Q9NP94 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra
SLC39A2 Q9NP94 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra
SLC39A2 Q9NP94 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra
SLC39A2 Q9NP94 SLC18A1 Homo sapiens P54219-3
Y2H Array
32296183
Intra
SLC39A2 Q9NP94 SLC18A1 Homo sapiens P54219-3
Y2H Prey Pooling
32296183
Intra
SLC39A2 Q9NP94 TRHR Homo sapiens P34981
Y2H Prey Pooling
32296183
Intra
SLC39A2 Q9NP94 TRHR Homo sapiens P34981
Y2H Array
32296183
Intra
SLC39A2 Q9NP94 GPR42 Homo sapiens O15529
Y2H Array
32296183
Intra
SLC39A2 Q9NP94 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra
SLC39A2 Q9NP94 SLC39A9 Homo sapiens Q9NUM3
Validated Y2H
32296183
Intra
SLC39A2 Q9NP94 CNR2 Homo sapiens P34972
Y2H Prey Pooling
32296183
Intra
SLC39A2 Q9NP94 CNR2 Homo sapiens P34972
Y2H Array
32296183
Intra
SLC39A2 Q9NP94 SLC7A1 Homo sapiens P30825
Y2H Array
32296183
Intra
SLC39A2 Q9NP94 SLC7A1 Homo sapiens P30825
Y2H Prey Pooling
32296183
Intra
SLC39A2 Q9NP94 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
SLC39A2 Q9NP94 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
SLC39A2 Q9NP94 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
SLC39A2 Q9NP94 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
SLC39A2 Q9NP94 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
SLC39A2 Q9NP94 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra
SLC39A2 Q9NP94 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra
SLC39A2 Q9NP94 LY6G6C Homo sapiens O95867
Y2H Prey Pooling
32296183
Intra
SLC39A2 Q9NP94 LY6G6C Homo sapiens O95867
Y2H Array
32296183
Intra
SLC39A2 Q9NP94 UBE2J1 Homo sapiens Q9Y385
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Carotid Artery Disease

  • Carotid Artery Diseases

  • Disorder Of Carotid Artery
Acrodermatitis Enteropathica, Zinc-Deficiency Type

  • Acrodermatitis Enteropathica

  • AEZ

  • Enteropathica

  • Brandt Syndrome

  • Ae

  • Acrodermatitis Enteropathica Zinc Deficiency Type

  • Danbolt-Cross Syndrome

  • Acrodermatitis Enteropathica, Zinc Deficiency Type

  • Inherited Zinc Deficiency

  • Acrodermatitis Enteropathica, Zinc Deficiency

  • Danbolt-Closs Syndrome

  • Primary Zinc Malabsorption Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13234 SLC39A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SLC39A2 MGD MGI:2684326
Rattus norvegicus SLC39A2 RGD RGD:1306291
Bos taurus SLC39A2 VGNC VGNC:34863
Canis familiaris SLC39A2 VGNC VGNC:46403
Felis catus SLC39A2 VGNC VGNC:65359
Others SLC39A2 NCBI