TRHR - thyrotropin releasing hormone receptor Gene

Also Known as CHNG7; TRH-R

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7201

About TRHR

Cytogenetic location: 8q23.1 Genomic coordinates (GRCh38): 8:109,086,585-109,121,565 (from NCBI)

This gene has 2 transcripts (splice variants), 269 orthologues, 15 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this gene have been associated with generalized thyrotropin-releasing hormone resistance. [provided by RefSeq, Sep 2011]

TRHR Products (1)

mRNA	Protein	Name
NM_003301.7	NP_003292.1	thyrotropin-releasing hormone receptor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRHR Protein Structure

7tm_1

0
100
200
300
398 a.a.

Protein Preferred Names	Protein Names
thyrotropin-releasing hormone receptor	thyroliberin receptor

TRHR Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRHR	P34981	TMEFF2	Homo sapiens	Q9UIK5	Validated Y2H	32296183
Intra	TRHR	P34981	TMEM239	Homo sapiens	Q8WW34-2	Validated Y2H	32296183
Intra	TRHR	P34981	C1QL4	Homo sapiens	Q86Z23	Validated Y2H	32296183
Intra	TRHR	P34981	FAM241B	Homo sapiens	Q96D05-2	Validated Y2H	32296183
Intra	TRHR	P34981	SLC41A1	Homo sapiens	Q8IVJ1	Validated Y2H	32296183
Intra	TRHR	P34981	SLC39A2	Homo sapiens	Q9NP94	Validated Y2H	32296183
Intra	TRHR	P34981	EFNA5	Homo sapiens	P52803	Validated Y2H	32296183
Intra	TRHR	P34981	SLC39A9	Homo sapiens	Q9NUM3	Validated Y2H	32296183
Intra	TRHR	P34981	ACP2	Homo sapiens	P11117	Anti Tag CoIP	28514442
Intra	TRHR	P34981	ACP2	Homo sapiens	P11117	Anti Tag CoIP	33961781
Intra	TRHR	P34981	IER3IP1	Homo sapiens	Q9Y5U9	Validated Y2H	32296183
Intra	TRHR	P34981	YIPF6	Homo sapiens	Q96EC8	Validated Y2H	32296183
Intra	TRHR	P34981	NIPAL4	Homo sapiens	Q0D2K0	Validated Y2H	32296183
Intra	TRHR	P34981	UBE2J1	Homo sapiens	Q9Y385	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

TRHR Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811191	TRHR Antibody	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Hypothyroidism, Congenital, Nongoitrous, 7	CHNG7 Thyrotropin-Releasing Hormone Resistance, Generalized Central Hypothyroidism Due To Trh Receptor Deficiency Resistance To Thyrotropin-Releasing Hormone Syndrome Trh Resistance Syndrome Congenital Nongoitrous Hypothyroidism 7 Hypothyroidism, Congenital, Non-Goitrous, 7 Hypothyroidism, Congenital, Nongoitrous, Type 7
Hypothyroidism	Thyroid Diseases Thyroid Disease Thyroid Deficiency Thyroid Insufficiency Dysfunction Thyroid Thyroid Dysfunction
Hypothyroidism, Central, With Testicular Enlargement	X-Linked Central Congenital Hypothyroidism With Late-Onset Testicular Enlargement CHTE Hypothyroidism, Central, And Testicular Enlargement Igsf1 Deficiency Syndrome X-Linked Central Congenital Hypothyroidism With Late-Onset Macroorchidism Central Hypothyroidism And Testicular Enlargement Hypothyroidism, Central, Testicular Enlargement
Acromegaly	Gigantism Growth Hormone Excess Pituitary Giant Somatotroph Adenoma Growth Hormone-Secreting Pituitary Adenoma
Congenital Hypothyroidism	Cretinism Neonatal Hypothyroidism Ch Cht Congenital Myxedema Myxedema, Congenital Endemic Cretinism Congenital Iodine-Deficiency Syndrome Fetal Iodine Deficiency Syndrome Congenital Iodine-Deficiency Hypothyroidism Nos
Hyperthyroidism	Overactive Thyroid

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0596	Taltirelin		99.91%	Unkown
HY-B0596A	Taltirelin acetate		99.75%	Unkown

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W331198	Tralopyril	Inducer	99.70%	Unkown
HY-B0596S	Taltirelin-13C,d3		/	Unkown
HY-RS15013	TRHR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20348	Trhr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26857	Trhr Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TRHR	VGNC	VGNC:36306
Mus musculus	TRHR	MGD	MGI:98824
Felis catus	TRHR	VGNC	VGNC:66526
Rattus norvegicus	TRHR	RGD	RGD:3904
Macaca mulatta	TRHR	VGNC	VGNC:78645
Canis familiaris	TRHR	VGNC	VGNC:47799
Others	TRHR	NCBI