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  3. Taltirelin acetate

Taltirelin acetate (Synonyms: TA-0910 (acetate))

Cat. No.: HY-B0596A Purity: 98.94%
Handling Instructions

Taltirelin acetate (TA-0910 acetate) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release).

For research use only. We do not sell to patients.

Taltirelin acetate Chemical Structure

Taltirelin acetate Chemical Structure

CAS No. : 1549593-23-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 96 In-stock
Estimated Time of Arrival: December 31
50 mg USD 384 In-stock
Estimated Time of Arrival: December 31
100 mg USD 696 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of Taltirelin acetate:

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Description

Taltirelin acetate (TA-0910 acetate) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release)[1].

IC50 & Target

IC50: 910 nM (Thyrotropin-releasing hormone receptor)[1]

Molecular Weight

465.46

Formula

C₁₉H₂₇N₇O₇

CAS No.

1549593-23-8

SMILES

O=C(N(CCC1)[[email protected]@H]1C(N)=O)[[email protected]@H](NC([[email protected]@H](NC2=O)CC(N2C)=O)=O)CC3=CN=CN3.CC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (268.55 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1484 mL 10.7421 mL 21.4841 mL
5 mM 0.4297 mL 2.1484 mL 4.2968 mL
10 mM 0.2148 mL 1.0742 mL 2.1484 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.47 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.47 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.47 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Taltirelin acetate
Cat. No.:
HY-B0596A
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