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MPTP hydrochloride 

Cat. No.: HY-15608 Purity: 99.16%
Data Sheet SDS Handling Instructions

MPTP (hydrochloride) is a prodrug to the neurotoxin MPP which causes permanent symptoms of Parkinson's disease.

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MPTP hydrochloride Chemical Structure

MPTP hydrochloride Chemical Structure

CAS No. : 23007-85-4

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10 mM * 1 mL in DMSO $55 In-stock
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50 mg $150 In-stock
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    MPTP hydrochloride purchased from MCE. Usage Cited in: Brain Res. 2016 Jul 1;1642:546-552.

    RNA 5hmC decreases in a MPTP-induced Parkinson's disease mouse model. MPTP (i.p. 60 mg/kg) is injected to induce Parkinson's disease model in mice. At 24 h after last MPTP injection, open field test is performed. After behavioral tests, the hippocampus (Hipo), the substantia nigra (SN), the striatum (Str), and the cortex (Ctx) are collected and total RNA is extracted. Total 100 ng RNA is used for dot blot analysis to detect 5hmC abundance in RNA samples from different brain regions. Methylene bl

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    • Biological Activity

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    Description

    MPTP (hydrochloride) is a prodrug to the neurotoxin MPP which causes permanent symptoms of Parkinson's disease.

    In Vitro

    Pretreatment with 50 mM 4-phenylpyridine, reduces IC50 (concentration for 50% inhibition of twitch amplitude) values of MPTP from 53 to 18 mM and d-tubocurarine from 0.7 to 0.3 mM, respectively, in mouse phrenic nerve-diaphragm[3].

    In Vivo

    The toxic effect of MPTP can be completely abolished in vivo by treatment with a monoamine oxidase inhibitor and potentiated by an inhibitor of catechol-O-methyltransferase[1]. Allopurinol potentiated the MPTP (35 mg/kg)-induced decrease in the DOPAC+HVA/DA ratio and increase in striatal AA oxidation of the rat[2]. Gas1 expressions are significantly elevated in the majority of the reactive astrocytes of the brains with LPS or MPTP insults in animal models[4].

    References
    Preparing Stock Solutions
    Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
    1 mM 4.7683 mL 23.8413 mL 47.6826 mL
    5 mM 0.9537 mL 4.7683 mL 9.5365 mL
    10 mM 0.4768 mL 2.3841 mL 4.7683 mL
    Animal Administration
    [4]

    MPTP is formulated in 0.9% saline.

    For the preparation of the LPS rat model and the MPTP mouse model, the treatments of the animals are performed. Briefly, adult rats receive unilateral injections of LPS (0.5 μL of 10 μg/μL diluted in 0.9% saline) into the medial forebrain bundle (MFB) at the following coordinates, AP-4.2 mm, L 1.5 mm, and V 7.8 mm, and into the contralateral side with the same volume of 0.9% saline. Adult mice are administered intraperitoneal injections of MPTP of 25 mg/kg per day for five continuous days, and the same volume of saline is injected as a control. All the animals are sacrificed at week 1, 2, 3, or 4 after the LPS or MPTP injections. The brain samples are collected for the subsequent immunohistochemistry and western blot experiments. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References
    Molecular Weight

    209.72

    Formula

    C₁₂H₁₆ClN

    CAS No.

    23007-85-4

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Solvent & Solubility

    DMSO: 12 mg/mL

    * "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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    Product Name:
    MPTP hydrochloride
    Cat. No.:
    HY-15608
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