RHBDL1 - rhomboid like 1 Gene

Also Known as RRP; RHBDL

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9028

Summary

This gene encodes a protein similar to Rhomboid in Drosophila which is involved in signalling in the Spitz/epidermal growth factor receptor/mitogen-activated protein kinase pathway. The Rhomboid family of proteins consists of intramembrane serine proteases containing several transmembrane domains. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Broad expression in brain (RPKM 2.4), kidney (RPKM 1.5) and 21 other tissues.

RHBDL1 Products (3)

mRNA Protein Name
NM_001278720.2 NP_001265649.1 rhomboid-related protein 1 isoform 1
NM_001278721.2 NP_001265650.1 rhomboid-related protein 1 isoform 2
NM_001318733.2 NP_001305662.1 rhomboid-related protein 1 isoform 3

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RHBDL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RHBDL1 O75783 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
RHBDL1 O75783 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
RHBDL1 O75783 KRTAP10-8 Homo sapiens P60410
Validated Y2H
32296183
Intra
RHBDL1 O75783 MFF Homo sapiens Q9GZY8-5
Validated Y2H
32296183
Intra
RHBDL1 O75783 C4orf3 Homo sapiens Q8WVX3-2
Validated Y2H
32296183
Intra
RHBDL1 O75783 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Prey Pooling
32296183
Intra
RHBDL1 O75783 KRTAP2-4 Homo sapiens Q9BYR9
Validated Y2H
32296183
Intra
RHBDL1 O75783 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Array
32296183
Intra
RHBDL1 O75783 VAC14 Homo sapiens Q08AM6
Validated Y2H
32296183
Intra
RHBDL1 O75783 VAC14 Homo sapiens Q08AM6
Y2H Array
32296183
Intra
RHBDL1 O75783 VAC14 Homo sapiens Q08AM6
Y2H Prey Pooling
32296183
Intra
RHBDL1 O75783 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra
RHBDL1 O75783 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
Intra
RHBDL1 O75783 ABHD16A Homo sapiens O95870
Validated Y2H
32296183
Intra
RHBDL1 O75783 COMT Homo sapiens P21964
Validated Y2H
32296183
Intra
RHBDL1 O75783 FXYD6 Homo sapiens Q9H0Q3
Validated Y2H
32296183
Intra
RHBDL1 O75783 APOD Homo sapiens P05090
Validated Y2H
32296183
Intra
RHBDL1 O75783 SPTSSA Homo sapiens Q969W0
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11934 RHBDF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11936 RHBDL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11931 RHBDD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11937 RHBDL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21185 Rhbdl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27701 Rhbdl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown