SLC16A7 - solute carrier family 16 member 7 Gene

Also Known as MCT2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9194

About SLC16A7

Cytogenetic location: 12q14.1 Genomic coordinates (GRCh38): 12:59,596,029-59,789,841 (from NCBI)

This gene has 16 transcripts (splice variants), 254 orthologues and 13 paralogues. Broad expression in fat (RPKM 11.7), heart (RPKM 9.2) and 22 other tissues.

Summary

This gene is a member of the Monocarboxylate Transporter family. Members in this family transport metabolites, such as lactate, pyruvate, and ketone bodies. The protein encoded by this gene catalyzes the proton-linked transport of monocarboxylates and has the highest affinity for pyruvate. This protein has been reported to be more highly expressed in prostate and colorectal Cancer specimens when compared to control specimens. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

SLC16A7 Products (14)

mRNA Protein Name
XM_017020226.3 XP_016875715.1 monocarboxylate transporter 2 isoform X3
XM_047429885.1 XP_047285841.1 monocarboxylate transporter 2 isoform X3
XM_024449276.2 XP_024305044.1 monocarboxylate transporter 2 isoform X2
NR_073056.2
XM_011538989.3 XP_011537291.1 monocarboxylate transporter 2 isoform X1
XM_011538992.3 XP_011537294.1 monocarboxylate transporter 2 isoform X1
NM_001270622.2 NP_001257551.1 monocarboxylate transporter 2
XM_011538990.4 XP_011537292.1 monocarboxylate transporter 2 isoform X1
NM_001270623.2 NP_001257552.1 monocarboxylate transporter 2
NR_073055.2
XM_011538991.3 XP_011537293.1 monocarboxylate transporter 2 isoform X1
NM_004731.5 NP_004722.2 monocarboxylate transporter 2
XM_011538995.3 XP_011537297.1 monocarboxylate transporter 2 isoform X3
XM_005269231.4 XP_005269288.1 monocarboxylate transporter 2 isoform X2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IDA
IDA: Inferred from direct assay
32415067 GOA
enables lactate transmembrane transporter activity IDA
IDA: Inferred from direct assay
9786900 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables pyruvate transmembrane transporter activity IDA
IDA: Inferred from direct assay
9786900 GOA
enables symporter activity IDA
IDA: Inferred from direct assay
32415067 GOA
Biological Process GO Annotation Evidence References Source
involved in lactate transmembrane transport IMP
IMP: Inferred from mutant phenotype
9786900 GOA
involved in pyruvate transmembrane transport IDA
IDA: Inferred from direct assay
9786900 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
15505343 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC16A7 Protein Structure

MFS_1

MFS_1: Major Facilitator Superfamily (27 - 390)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 478 a.a.
Protein Preferred Names Protein Names

monocarboxylate transporter 2

  • solute carrier family 16 (monocarboxylate transporter), member 7

  • solute carrier family 16, member 7 (monocarboxylic acid transporter 2)

SLC16A7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SLC16A7 O60669 SMAGP Homo sapiens Q0VAQ4
Validated Y2H
32296183
Intra
SLC16A7 O60669 VAPA Homo sapiens Q9P0L0
Validated Y2H
32296183
Intra
SLC16A7 O60669 LEMD1 Homo sapiens Q68G75
Validated Y2H
32296183
Intra
SLC16A7 O60669 HMOX1 Homo sapiens P09601
Validated Y2H
32296183
Intra
SLC16A7 O60669 ACSL5 Homo sapiens Q9ULC5
Validated Y2H
32296183
Intra
SLC16A7 O60669 SFXN1 Homo sapiens Q9H9B4
Validated Y2H
32296183
Intra
SLC16A7 O60669 COMT Homo sapiens P21964
Validated Y2H
32296183
Intra
SLC16A7 O60669 FXYD6 Homo sapiens Q9H0Q3
Validated Y2H
32296183
Intra
SLC16A7 O60669 VTI1B Homo sapiens Q9UEU0
Validated Y2H
32296183
Intra
SLC16A7 O60669 IFITM3 Homo sapiens Q01628
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Pharynx Squamous Cell Carcinoma
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13030 Slc16a7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13029 SLC16A7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13031 Slc16a7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SLC16A7 VGNC VGNC:46245
Felis catus SLC16A7 VGNC VGNC:65214
Bos taurus SLC16A7 VGNC VGNC:34693
Mus musculus SLC16A7 MGD MGI:1330284
Macaca mulatta SLC16A7 VGNC VGNC:77400
Rattus norvegicus SLC16A7 RGD RGD:3691
Others SLC16A7 NCBI