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ACSL5 - acyl-CoA synthetase long chain family member 5 Gene

Also Known as ACS2; ACS5; FACL5

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 51703

About ACSL5

Cytogenetic location: 10q25.2 Genomic coordinates (GRCh38): 10:112,374,116-112,428,376 (from NCBI)

This gene has 8 transcripts (splice variants), 199 orthologues and 12 paralogues. Biased expression in small intestine (RPKM 203.8), duodenum (RPKM 170.4) and 10 other tissues.

Summary

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A Ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ACSL5 Products (4)

mRNA	Protein	Name
NM_001387037.1	NP_001373966.1	long-chain-fatty-acid--CoA ligase 5 isoform c
NM_016234.4	NP_057318.2	long-chain-fatty-acid--CoA ligase 5 isoform a
NM_203379.2	NP_976313.1	long-chain-fatty-acid--CoA ligase 5 isoform b
NM_203380.2	NP_976314.1	long-chain-fatty-acid--CoA ligase 5 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables long-chain fatty acid-CoA ligase activity	IDA IDA: Inferred from direct assay	17681178	GOA
enables long-chain fatty acid-CoA ligase activity	IMP IMP: Inferred from mutant phenotype	22633490	GOA
enables oleoyl-CoA ligase activity	IDA IDA: Inferred from direct assay	33191500	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in long-chain fatty acid metabolic process	IDA IDA: Inferred from direct assay	17681178	GOA
involved in long-chain fatty acid metabolic process	IMP IMP: Inferred from mutant phenotype	22633490	GOA
involved in regulation of extrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	17681178	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	17681178	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	17681178	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	24269233	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACSL5 Protein Structure

AMP-binding

0
200
400
600
683 a.a.

Protein Preferred Names	Protein Names
long-chain-fatty-acid--CoA ligase 5	FACL5 for fatty acid coenzyme A ligase 5

ACSL5 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	ACSL5	Q9ULC5	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	ACSL5	Q9ULC5	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	ACSL5	Q9ULC5	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	ACSL5	Q9ULC5	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	ACSL5	Q9ULC5	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Prey Pooling	32296183
Intra	ACSL5	Q9ULC5	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Array	32296183
Intra	ACSL5	Q9ULC5	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	ACSL5	Q9ULC5	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	ACSL5	Q9ULC5	SLC16A7	Homo sapiens	O60669	Y2H Array	32296183
Intra	ACSL5	Q9ULC5	SLC16A7	Homo sapiens	O60669	Y2H Prey Pooling	32296183
Intra	ACSL5	Q9ULC5	SLC10A1	Homo sapiens	Q14973	Y2H Prey Pooling	32296183
Intra	ACSL5	Q9ULC5	SLC10A1	Homo sapiens	Q14973	Y2H Array	32296183
Intra	ACSL5	Q9ULC5	SLC7A14	Homo sapiens	Q8TBB6	Y2H Prey Pooling	32296183
Intra	ACSL5	Q9ULC5	SLC7A14	Homo sapiens	Q8TBB6	Y2H Array	32296183
Intra	ACSL5	Q9ULC5	PEX12	Homo sapiens	O00623	Y2H Array	32296183
Intra	ACSL5	Q9ULC5	PEX12	Homo sapiens	O00623	Y2H Prey Pooling	32296183
Intra	ACSL5	Q9ULC5	SELI	Homo sapiens	Q8WU57	Y2H Prey Pooling	32296183
Intra	ACSL5	Q9ULC5	SELI	Homo sapiens	Q8WU57	Y2H Array	32296183
Intra	ACSL5	Q9ULC5	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	ACSL5	Q9ULC5	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	ACSL5	Q9ULC5	EBAG9	Homo sapiens	O00559	Y2H Array	32296183
Intra	ACSL5	Q9ULC5	EBAG9	Homo sapiens	O00559	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

ACSL5 抗体

製品番号	製品名	アプリケーション	反応性
HY-P86763	ACSL5 Antibody (YA6456)	WB, IHC-P	Human, Mouse, Rat

Diseases	Alias
Glioma
Non-Syndromic X-Linked Intellectual Disability 63	Acsl4-Related Intellectual Disability Mrx63 Mrx68 X-Linked Mental Retardation 68

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-177705	ACSL5-IN-2	Inhibitor	99.51%	Unkown
HY-177704	ACSL5-IN-1	Inhibitor	99.88%	Unkown
HY-186096	LP-856866	Inhibitor	99.92%	Unkown
HY-186095	LP-911888	Inhibitor	99.83%	Unkown
HY-177850	ACSL5-IN-3		99.74%	Unkown
HY-186084	ACSL5-IN-4		/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Macaca mulatta	ACSL5	VGNC	VGNC:69431
Canis familiaris	ACSL5	VGNC	VGNC:37535
Mus musculus	ACSL5	MGD	MGI:1919129
Rattus norvegicus	ACSL5	RGD	RGD:69402
Bos taurus	ACSL5	VGNC	VGNC:25567
Felis catus	ACSL5	VGNC	VGNC:59537
Others	ACSL5	NCBI