LP-911888 

LP-911888 is an orally active ACSL5/ACSL1 inhibitor, with IC₅₀ values of 1 nM and 3 nM against mouse and human ACSL5, and IC₅₀ values of 2 nM and 9 nM against mouse and human ACSL1, respectively. LP-911888 inhibits intestinal triglyceride uptake; it also reduces body weight and food consumption in diet-induced obese mice, and delays gastric emptying by activating the ileal brake pathway. LP-911888 can be used in studies of diet-induced obesity^[1].

LP-911888 (1-10 mg/kg; p.o.) dose-dependently inhibits intestinal triglyceride uptake. It also reduces body weight and food intake in diet-induced obese mice, and delays gastric emptying by activating the ileal brake pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

523.52

C₂₄H₂₄F₃N₃O₅S

Solid

White to light yellow

C[C@H](C1=CC=C(C=N1)OC2=CC=CC=N2)OC3=CC=C(C=C3C(F)(F)F)C(NS(=O)(C(C)(C)C)=O)=O

Room temperature in continental US; may vary elsewhere.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Powell DR, et al. Acyl-CoA Synthetase 5 Knockout and Inhibitors Protect Against Diet-Induced Obesity in Mice by Activating the Ileal Brake. J Endocr Soc. 2025;10(2):bvaf196. Published 2025 Nov 28.  [Content Brief]