2. Metabolic Enzyme/Protease Others
  3. ACSL Family Drug Derivative
  4. ACSL5-IN-1

ACSL5-IN-1 (Compound A) is an ACSL5 inhibitor with body weight-reducing activity. ACSL5-IN-1 inhibits ACSL5, an enzyme linked to fatty acid metabolism. ACSL5-IN-1 reduces body weight in diet-induced obesity mice. ACSL5-IN-1 can be used for the research of obesity, metabolic dysfunction-associated steatohepatitis, metabolic syndrome, non-alcoholic fatty liver disease, type 2 diabetes, acute myeloid leukemia, colorectal cancer, and breast cancer.

For research use only. We do not sell to patients.

ACSL5-IN-1

ACSL5-IN-1 Chemical Structure

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Based on 1 publication(s) in Google Scholar

ACSL5-IN-1 Related Antibodies

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ACSL4 ACSL5

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Description

ACSL5-IN-1 (Compound A) is an ACSL5 inhibitor with body weight-reducing activity. ACSL5-IN-1 inhibits ACSL5, an enzyme linked to fatty acid metabolism. ACSL5-IN-1 reduces body weight in diet-induced obesity mice. ACSL5-IN-1 can be used for the research of obesity, metabolic dysfunction-associated steatohepatitis, metabolic syndrome, non-alcoholic fatty liver disease, type 2 diabetes, acute myeloid leukemia, colorectal cancer, and breast cancer[1].

IC50 & Target

ACSL5

 

In Vitro

Long-chain acyl-CoA synthetase family member 5 (ACSL5) is widely expressed in the liver, small intestine, adipose tissue, spleen, uterus, lung and skeletal muscle of mammals. ACSL5 catalyzes the conversion of long-chain fatty acids in the cytoplasm to acyl-CoA. These acyl-CoA molecules are subsequently used for the synthesis of complex lipids and other products in the endoplasmic reticulum, or enter mitochondria for γ-oxidation. Fatty acids catalyzed by ACSL5 include palmitic acid, palmitoleic acid, oleic acid and linoleic acid.
Studies show that ACSL5 is involved in glucose and lipid metabolism, and may play an important role in metabolic disorders. For example, ACSL5-/- mice exhibit increased FGF21 levels in the liver and serum, reduced fat mass, improved insulin sensitivity, increased energy expenditure and delayed triglyceride absorption[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ACSL5-IN-1 Related Antibodies
Molecular Weight

523.52

Formula

C24H24F3N3O5S
Appearance

Solid

Color

White to off-white

SMILES

O=C(NS(=O)(C(C)(C)C)=O)C1=CC=C(O[C@@H](C2=NC=C(OC3=CC=CN=C3)C=C2)C)C(C(F)(F)F)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 4.17 mg/mL (7.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9101 mL 9.5507 mL 19.1015 mL
5 mM 0.3820 mL 1.9101 mL 3.8203 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.88%

SDS (251 KB)

COA (248 KB) HNMR (280 KB) LCMS (102 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9101 mL 9.5507 mL 19.1015 mL 47.7537 mL
5 mM 0.3820 mL 1.9101 mL 3.8203 mL 9.5507 mL
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ACSL5-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ACSL5-IN-1ACSL FamilyDrug DerivativeDrug derivativemetabolic dysfunction-associated steatohepatitismetabolic syndromeacute myeloid leukemiatype 2 diabetescolorectal cancerACSL5obesitynon-alcoholic fatty liver diseasediet-induced obesity micefatty acid metabolismInhibitorinhibitorinhibit

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