ACSL5-IN-1
Based on 1 Customer Validation
ACSL5-IN-1 (Compound A) is an ACSL5 inhibitor with body weight-reducing activity. ACSL5-IN-1 inhibits ACSL5, an enzyme linked to fatty acid metabolism. ACSL5-IN-1 reduces body weight in diet-induced obesity mice. ACSL5-IN-1 can be used for the research of obesity, metabolic dysfunction-associated steatohepatitis, metabolic syndrome, non-alcoholic fatty liver disease, type 2 diabetes, acute myeloid leukemia, colorectal cancer, and breast cancer.
For research use only. We do not sell to patients.
- Purity: 99.88%
- Formula: C24H24F3N3O5S
- Molecular Weight:523.52
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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ACSL5 |
Long-chain acyl-CoA synthetase family member 5 (ACSL5) is widely expressed in the liver, small intestine, adipose tissue, spleen, uterus, lung and skeletal muscle of mammals. ACSL5 catalyzes the conversion of long-chain fatty acids in the cytoplasm to acyl-CoA. These acyl-CoA molecules are subsequently used for the synthesis of complex lipids and other products in the endoplasmic reticulum, or enter mitochondria for γ-oxidation. Fatty acids catalyzed by ACSL5 include palmitic acid, palmitoleic acid, oleic acid and linoleic acid.
Studies show that ACSL5 is involved in glucose and lipid metabolism, and may play an important role in metabolic disorders. For example, ACSL5-/- mice exhibit increased FGF21 levels in the liver and serum, reduced fat mass, improved insulin sensitivity, increased energy expenditure and delayed triglyceride absorption[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 523.52
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Formula C24H24F3N3O5S
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Color White to off-white
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SMILES
O=C(NS(=O)(C(C)(C)C)=O)C1=CC=C(O[C@@H](C2=NC=C(OC3=CC=CN=C3)C=C2)C)C(C(F)(F)F)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 4.17 mg/mL (7.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.9101 mL | 9.5507 mL | 19.1015 mL | 47.7537 mL |
| 5 mM | 0.3820 mL | 1.9101 mL | 3.8203 mL | 9.5507 mL |
ACSL5-IN-1 Related Classifications
HY-177704 Related Classifications
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